Effects of memantine and galantamine given separately or in association, on memory and hippocampal neuronal loss after transient global cerebral ischemia in gerbils

Brain Research

Volumn 1254, Issue , 2009, Pages 128-137

  Lorrio, Silvia ^a,c   Negredo, Pilar ^a,c   Roda, José M ^c   García, Antonio G ^a,b,d   López, Manuela G ^a,b,d  

^a INSTITUTO TEÓFILO HERNANDO   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^d HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

Author keywords

Brain ischemia and reperfusion; Immunohistochemistry; Neuroprotection; Object placement test

Indexed keywords

CASPASE 3; CHOLINESTERASE INHIBITOR; GALANTAMINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPROTECTIVE AGENT; SUPEROXIDE DISMUTASE;

ANIMAL; ARTICLE; BRAIN ISCHEMIA; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; GERBIL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MEMORY; METABOLISM; NICK END LABELING; PATHOLOGY; PSYCHOLOGICAL ASPECT; PYRAMIDAL NERVE CELL;

ANIMALS; BRAIN ISCHEMIA; CASPASE 3; CELL SURVIVAL; CHOLINESTERASE INHIBITORS; GALANTAMINE; GERBILLINAE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MEMANTINE; MEMORY; NEUROPROTECTIVE AGENTS; PYRAMIDAL CELLS; RECEPTORS, N-METHYL-D-ASPARTATE; SUPEROXIDE DISMUTASE;

EID: 58549086520     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.11.095     Document Type: Article

References (51)

1. Arias E., Ales E., Gabilan N.H., Cano-Abad M.F., Villarroya M., Garcia A.G., and Lopez M.G. Galantamine prevents apoptosis induced by beta-amyloid and thapsigargin: involvement of nicotinic acetylcholine receptors. Neuropharmacology 46 1 (2004) 103-114
2. Arias E., Gallego-Sandin S., Villarroya M., Garcia A.G., and Lopez M.G. Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells: role of nicotinic receptors. J. Pharmacol. Exp. Ther. 315 3 (2005) 1346-1353
3. Back T., Otto D., Kittner D., Schuler O.G., Hennerici M.G., and Mennel H.D. Failure to improve the effect of thrombolysis by memantine in a rat embolic stroke model. Neurol. Res. 29 3 (2007) 264-269
4. Backhauss C., and Krieglstein J. Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents. Eur. J. Pharmacol. 215 2-3 (1992) 265-269
5. Blalock E.M., Chen K.C., Sharrow K., Herman J.P., Porter N.M., Foster T.C., and Landfield P.W. Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment. J. Neurosci. 23 9 (2003) 3807-3819
6. Block F., and Schwarz M. Memantine reduces functional and morphological consequences induced by global ischemia in rats. Neurosci. Lett. 208 1 (1996) 41-44
7. Bores G.M., Huger F.P., Petko W., Mutlib A.E., Camacho F., Rush D.K., Selk D.E., Wolf V., Kosley Jr. R.W., Davis L., and Vargas H.M. Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine. J. Pharmacol. Exp. Ther. 277 2 (1996) 728-738
8. Bormann J. Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels. Eur. J. Pharmacol. 166 3 (1989) 591-592
9. Capsoni S., Giannotta S., and Cattaneo A. Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc. Natl. Acad. Sci. U. S. A. 99 19 (2002) 12432-12437
10. Chen H.S., Wang Y.F., Rayudu P.V., Edgecomb P., Neill J.C., Segal M.M., Lipton S.A., and Jensen F.E. Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience 86 4 (1998) 1121-1132
11. Culmsee C., Junker V., Kremers W., Thal S., Plesnila N., and Krieglstein J. Combination therapy in ischemic stroke: synergistic neuroprotective effects of memantine and clenbuterol. Stroke 35 5 (2004) 1197-1202
12. Danilczuk Z., Ossowska G., Lupina T., Cieslik K., and Zebrowska-Lupina I. Effect of NMDA receptor antagonists on behavioral impairment induced by chronic treatment with dexamethasone. Pharmacol. Rep. 57 1 (2005) 47-54
13. Danysz W., Gossel M., Zajaczkowski W., Dill D., and Quack G. Are NMDA antagonistic properties relevant for anti-Parkinsonian-like activity in rats?-case of amantadine and memantine. J. Neural. Transm. Parkinson's Dis. Dement. Sect. 7 3 (1994) 155-166
14. Dogan A., Eras M.A., Rao V.L., and Dempsey R.J. Protective effects of memantine against ischemia-reperfusion injury in spontaneously hypertensive rats. Acta Neurochir. (Wien) 141 10 (1999) 1107-1113
15. Dohmen C., Kumura E., Rosner G., Heiss W.D., and Graf R. Extracellular correlates of glutamate toxicity in short-term cerebral ischemia and reperfusion: a direct in vivo comparison between white and gray matter. Brain Res. 1037 1-2 (2005) 43-51
16. Duszczyk M., Gadamski R., Ziembowicz A., Danysz W., and Lazarewicz J.W. NMDA receptor antagonism does not inhibit induction of ischemic tolerance in gerbil brain in vivo. Neurotox. Res. 7 4 (2005) 283-292
17. Ennaceur A., Neave N., and Aggleton J.P. Spontaneous object recognition and object location memory in rats: the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix. Exp. Brain Res. 113 3 (1997) 509-519
18. Erkinjuntti T., Kurz A., Small G.W., Bullock R., Lilienfeld S., and Damaraju C.V. An open-label extension trial of galantamine in patients with probable vascular dementia and mixed dementia. Clin. Ther. 25 6 (2003) 1765-1782
19. Ezoulin M.J., Ombetta J.E., Dutertre-Catella H., Warnet J.M., and Massicot F. Antioxidative properties of galantamine on neuronal damage induced by hydrogen peroxide in SK-N-SH cells. Neurotoxicology 29 2 (2008) 270-277
20. Gao Y., Chen H.J., Qian L.H., and Chen G.Y. Long-term effects of memantine therapy on neonatal rats with hypoxic-ischemic brain damage. Zhongguo Dang Dai Er Ke Za Zhi 8 1 (2006) 38-40
21. Gorgulu A., Kins T., Cobanoglu S., Unal F., Izgi N.I., Yanik B., and Kucuk M. Reduction of edema and infarction by Memantine and MK-801 after focal cerebral ischaemia and reperfusion in rat. Acta Neurochir. (Wien) 142 11 (2000) 1287-1292
22. Hesselink M.B., De Boer B.G., Breimer D.D., and Danysz W. Brain penetration and in vivo recovery of NMDA receptor antagonists amantadine and memantine: a quantitative microdialysis study. Pharm. Res. 16 5 (1999) 637-642
23. Ikonomidou C., Stefovska V., and Turski L. Neuronal death enhanced by N-methyl-D-aspartate antagonists. Proc. Natl. Acad. Sci. U. S. A. 97 23 (2000) 12885-12890
24. Iliev A.I., Traykov V.B., Mantchev G.T., Stoykov I., Prodanov D., Yakimova K.S., and Krushkov I.M. A post-ischaemic single administration of galantamine, a cholinesterase inhibitor, improves learning ability in rats. J. Pharm. Pharmacol. 52 9 (2000) 1151-1156
25. Ji X., Li C., Lu Y., Chen Y., and Guo L. Post-ischemic continuous administration of galantamine attenuates cognitive deficits and hippocampal neurons loss after transient global ischemia in gerbils. Neurosci. Lett. 416 1 (2007) 92-95
26. Kihara T., Sawada H., Nakamizo T., Kanki R., Yamashita H., Maelicke A., and Shimohama S. Galantamine modulates nicotinic receptor and blocks Abeta-enhanced glutamate toxicity. Biochem. Biophys. Res. Commun. 325 3 (2004) 976-982
27. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239 1 (1982) 57-69
28. Lapchak P.A. Memantine, an uncompetitive low affinity NMDA open-channel antagonist improves clinical rating scores in a multiple infarct embolic stroke model in rabbits. Brain Res. 1088 1 (2006) 141-147
29. Lorrio S., Sobrado M., Arias E., Roda J.M., Garcia A.G., and Lopez M.G. Galantamine post ischemia provides neuroprotection and memory recovery against transient global cerebral ischemia in gerbils. J. Pharmacol. Exp. Ther. 322 2 (2007) 591-599
30. McGraw C.P. Experimental cerebral infarction effects of pentobarbital in Mongolian gerbils. Arch. Neurol. 34 6 (1977) 334-336
31. Misztal M., Frankiewicz T., Parsons C.G., and Danysz W. Learning deficits induced by chronic intraventricular infusion of quinolinic acid-protection by MK-801 and memantine. Eur. J. Pharmacol. 296 1 (1996) 1-8
32. Moriguchi S., Marszalec W., Zhao X., Yeh J.Z., and Narahashi T. Mechanism of action of galantamine on N-methyl-D-aspartate receptors in rat cortical neurons. J. Pharmacol. Exp. Ther. 310 3 (2004) 933-942
33. Nakayama R., Yano T., Ushijima K., Abe E., and Terasaki H. Effects of dantrolene on extracellular glutamate concentration and neuronal death in the rat hippocampal CA1 region subjected to transient ischemia. Anesthesiology 96 3 (2002) 705-710
34. Orgogozo J.M., Rigaud A.S., Stoffler A., Mobius H.J., and Forette F. Efficacy and safety of memantine in patients with mild to moderate vascular dementia: a randomized, placebo-controlled trial (MMM 300). Stroke 33 7 (2002) 1834-1839
35. Parsons C.G., Danysz W., and Quack G. Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist-a review of preclinical data. Neuropharmacology 38 6 (1999) 735-767
36. Porsteinsson A.P., Grossberg G.T., Mintzer J., and Olin J.T. Memantine treatment in patients with mild to moderate Alzheimer's disease already receiving a cholinesterase inhibitor: a randomized, double-blind, placebo-controlled trial. Curr. Alzheimer Res. 5 1 (2008) 83-89
37. Rimpilainen J., Pokela M., Kiviluoma K., Vainionpaa V., Hirvonen J., Ohtonen P., Jantti V., Anttila V., Heinonen H., and Juvonen T. The N-methyl-D-aspartate antagonist memantine has no neuroprotective effect during hypothermic circulatory arrest: a study in the chronic porcine model. J. Thorac. Cardiovasc. Surg. 121 5 (2001) 957-968 discussion 968-970
38. Santos M.D., Alkondon M., Pereira E.F., Aracava Y., Eisenberg H.M., Maelicke A., and Albuquerque E.X. The nicotinic allosteric potentiating ligand galantamine facilitates synaptic transmission in the mammalian central nervous system. Mol. Pharmacol. 61 5 (2002) 1222-1234
39. Schilstrom B., Ivanov V.B., Wiker C., and Svensson T.H. Galantamine enhances dopaminergic neurotransmission in vivo via allosteric potentiation of nicotinic acetylcholine receptors. Neuropsychopharmacology 32 1 (2007) 43-53
40. Schrattenholz A., Pereira E.F., Roth U., Weber K.H., Albuquerque E.X., and Maelicke A. Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting ligands. Mol. Pharmacol. 49 1 (1996) 1-6
41. Seif el Nasr M., Peruche B., Rossberg C., Mennel H.D., and Krieglstein J. Neuroprotective effect of memantine demonstrated in vivo and in vitro. Eur. J. Pharmacol. 185 1 (1990) 19-24
42. Sobrado M., Roda J.M., Lopez M.G., Egea J., and Garcia A.G. Galantamine and memantine produce different degrees of neuroprotection in rat hippocampal slices subjected to oxygen-glucose deprivation. Neurosci. Lett. 365 2 (2004) 132-136
43. Stieg P.E., Sathi S., Warach S., Le D.A., and Lipton S.A. Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat. Eur. J. Pharmacol. 375 1-3 (1999) 115-120
44. Thomsen T., and Kewitz H. Selective inhibition of human acetylcholinesterase by galanthamine in vitro and in vivo. Life Sci. 46 21 (1990) 1553-1558
45. Traykova M., Traykov T., Hadjimitova V., Krikorian K., and Bojadgieva N. Antioxidant properties of galantamine hydrobromide. Z. Naturforsch., C 58 5-6 (2003) 361-365
46. Wenk G.L., Parsons C.G., and Danysz W. Potential role of N-methyl-D-aspartate receptors as executors of neurodegeneration resulting from diverse insults: focus on memantine. Behav. Pharmacol. 17 5-6 (2006) 411-424
47. Woodruff-Pak D.S., Tobia M.J., Jiao X., Beck K.D., and Servatius R.J. Preclinical investigation of the functional effects of memantine and memantine combined with galantamine or donepezil. Neuropsychopharmacology 32 6 (2007) 1284-1294
48. Yano S., Tokumitsu H., and Soderling T.R. Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Nature 396 6711 (1998) 584-587
49. Yu S., and Cai J. Effects of aniracetam on extracellular levels of transmitter amino acids in the hippocampus of the conscious gerbils: an intracranial microdialysis study. Neurosci. Lett. 339 3 (2003) 187-190
50. Zhao C.S., Puurunen K., Schallert T., Sivenius J., and Jolkkonen J. Effect of cholinergic medication, before and after focal photothrombotic ischemic cortical injury, on histological and functional outcome in aged and young adult rats. Behav. Brain Res. 156 1 (2005) 85-94
51. Zhao X., Marszalec W., Toth P.T., Huang J., Yeh J.Z., and Narahashi T. In vitro galantamine-memantine co-application: mechanism of beneficial action. Neuropharmacology 51 7-8 (2006) 1181-1191