메뉴 건너뛰기




Volumn 1088, Issue 1, 2006, Pages 141-147

Memantine, an uncompetitive low affinity NMDA open-channel antagonist improves clinical rating scores in a multiple infarct embolic stroke model in rabbits

Author keywords

Acute ischemic stroke; Behavior; Clinical; Embolism; Neuroprotection; Toxicity

Indexed keywords

AMPICILLIN; DRUG VEHICLE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

EID: 33747390182     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.02.093     Document Type: Article
Times cited : (26)

References (42)
  • 1
    • 0028787964 scopus 로고
    • Chronic treatment with the uncompetitive NMDA receptor antagonist memantine influences the polyamine and glycine binding sites of the NMDA receptor complex in aged rats
    • Bresink I., Danysz W., Parsons C.G., Tiedtke P., and Mutschler E. Chronic treatment with the uncompetitive NMDA receptor antagonist memantine influences the polyamine and glycine binding sites of the NMDA receptor complex in aged rats. J. Neural Transm., Parkinson's Dis. Dement. Sect. 10 (1995) 11-26
    • (1995) J. Neural Transm., Parkinson's Dis. Dement. Sect. , vol.10 , pp. 11-26
    • Bresink, I.1    Danysz, W.2    Parsons, C.G.3    Tiedtke, P.4    Mutschler, E.5
  • 3
    • 0025396451 scopus 로고
    • Do NMDA antagonists protect against cerebral ischemia: are clinical trials warranted?
    • Buchan A.M. Do NMDA antagonists protect against cerebral ischemia: are clinical trials warranted?. Cerebrovasc. Brain Metab. Rev. 2 (1990) 1-26
    • (1990) Cerebrovasc. Brain Metab. Rev. , vol.2 , pp. 1-26
    • Buchan, A.M.1
  • 4
    • 0031034905 scopus 로고    scopus 로고
    • Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism
    • Chen H.S., and Lipton S.A. Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. J. Physiol. 499 Pt 1 (1997) 27-46
    • (1997) J. Physiol. , vol.499 , Issue.PART 1 , pp. 27-46
    • Chen, H.S.1    Lipton, S.A.2
  • 5
    • 0032543788 scopus 로고    scopus 로고
    • Neuroprotective concentrations of the N-methyl-d-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation
    • Chen H.S., Wang Y.F., Rayudu P.V., Edgecomb P., Neill J.C., Segal M.M., Lipton S.A., and Jensen F.E. Neuroprotective concentrations of the N-methyl-d-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience 86 (1998) 1121-1132
    • (1998) Neuroscience , vol.86 , pp. 1121-1132
    • Chen, H.S.1    Wang, Y.F.2    Rayudu, P.V.3    Edgecomb, P.4    Neill, J.C.5    Segal, M.M.6    Lipton, S.A.7    Jensen, F.E.8
  • 6
    • 0024405516 scopus 로고
    • Selective vulnerability of the brain: new insights into the pathophysiology of stroke
    • Collins R.C., Dobkin B.H., and Choi D.W. Selective vulnerability of the brain: new insights into the pathophysiology of stroke. Ann. Intern Med. 110 (1989) 992-1000
    • (1989) Ann. Intern Med. , vol.110 , pp. 992-1000
    • Collins, R.C.1    Dobkin, B.H.2    Choi, D.W.3
  • 7
    • 2142654428 scopus 로고    scopus 로고
    • Combination therapy in ischemic stroke: synergistic neuroprotective effects of memantine and clenbuterol
    • Culmsee C., Junker V., Kremers W., Thal S., Plesnila N., and Krieglstein J. Combination therapy in ischemic stroke: synergistic neuroprotective effects of memantine and clenbuterol. Stroke 35 (2004) 1197-1202
    • (2004) Stroke , vol.35 , pp. 1197-1202
    • Culmsee, C.1    Junker, V.2    Kremers, W.3    Thal, S.4    Plesnila, N.5    Krieglstein, J.6
  • 8
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: an integrated view
    • Dirnagl U., Iadecola C., and Moskowitz M.A. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 22 (1999) 391-397
    • (1999) Trends Neurosci. , vol.22 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 9
    • 1842845103 scopus 로고    scopus 로고
    • Memantine for patients with Alzheimer disease
    • (author reply 1695)
    • Finucane T.E. Memantine for patients with Alzheimer disease. JAMA 291 (2004) 1695 (author reply 1695)
    • (2004) JAMA , vol.291 , pp. 1695
    • Finucane, T.E.1
  • 10
    • 0037975646 scopus 로고    scopus 로고
    • Recommendations for advancing development of acute stroke therapies: stroke therapy academic industry roundtable 3 (STAIR-III)
    • Fisher M. Recommendations for advancing development of acute stroke therapies: stroke therapy academic industry roundtable 3 (STAIR-III). Stroke 34 (2003) 1539-1546
    • (2003) Stroke , vol.34 , pp. 1539-1546
    • Fisher, M.1
  • 11
    • 0032810628 scopus 로고    scopus 로고
    • Memantine restores long term potentiation impaired by tonic N-methyl-d-aspartate (NMDA) receptor activation following reduction of Mg2+ in hippocampal slices
    • Frankiewicz T., and Parsons C.G. Memantine restores long term potentiation impaired by tonic N-methyl-d-aspartate (NMDA) receptor activation following reduction of Mg2+ in hippocampal slices. Neuropharmacology 38 (1999) 1253-1259
    • (1999) Neuropharmacology , vol.38 , pp. 1253-1259
    • Frankiewicz, T.1    Parsons, C.G.2
  • 12
    • 0030029425 scopus 로고    scopus 로고
    • Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices
    • Frankiewicz T., Potier B., Bashir Z.I., Collingridge G.L., and Parsons C.G. Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices. Br. J. Pharmacol. 117 (1996) 689-697
    • (1996) Br. J. Pharmacol. , vol.117 , pp. 689-697
    • Frankiewicz, T.1    Potier, B.2    Bashir, Z.I.3    Collingridge, G.L.4    Parsons, C.G.5
  • 14
    • 0023723433 scopus 로고
    • Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and gamma-aminobutyric acid studied by intracerebral microdialysis
    • Globus M.Y., Busto R., Dietrich W.D., Martinez E., Valdes I., and Ginsberg M.D. Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and gamma-aminobutyric acid studied by intracerebral microdialysis. J. Neurochem. 51 (1988) 1455-1464
    • (1988) J. Neurochem. , vol.51 , pp. 1455-1464
    • Globus, M.Y.1    Busto, R.2    Dietrich, W.D.3    Martinez, E.4    Valdes, I.5    Ginsberg, M.D.6
  • 15
    • 0034538373 scopus 로고    scopus 로고
    • Reduction of edema and infarction by memantine and MK-801 after focal cerebral ischaemia and reperfusion in rat
    • Gorgulu A., Kins T., Cobanoglu S., Unal F., Izgi N.I., Yanik B., and Kucuk M. Reduction of edema and infarction by memantine and MK-801 after focal cerebral ischaemia and reperfusion in rat. Acta Neurochir. (Wien) 142 (2000) 1287-1292
    • (2000) Acta Neurochir. (Wien) , vol.142 , pp. 1287-1292
    • Gorgulu, A.1    Kins, T.2    Cobanoglu, S.3    Unal, F.4    Izgi, N.I.5    Yanik, B.6    Kucuk, M.7
  • 16
    • 33747420126 scopus 로고    scopus 로고
    • Memantine was better than placebo in Alzheimer disease already being treated with donepezil
    • Hirsch C.H. Memantine was better than placebo in Alzheimer disease already being treated with donepezil. ACP J. Club 141 (2004) 38
    • (2004) ACP J. Club , vol.141 , pp. 38
    • Hirsch, C.H.1
  • 17
    • 0023836750 scopus 로고
    • Glutamate antagonist therapy reduces neurologic deficits produced by focal central nervous system ischemia
    • Kochhar A., Zivin J.A., Lyden P.D., and Mazzarella V. Glutamate antagonist therapy reduces neurologic deficits produced by focal central nervous system ischemia. Arch. Neurol. 45 (1988) 148-153
    • (1988) Arch. Neurol. , vol.45 , pp. 148-153
    • Kochhar, A.1    Zivin, J.A.2    Lyden, P.D.3    Mazzarella, V.4
  • 18
    • 0026090826 scopus 로고
    • Pharmacologic studies of the neuroprotective actions of a glutamate antagonist in ischemia
    • Kochhar A., Zivin J.A., and Mazzarella V. Pharmacologic studies of the neuroprotective actions of a glutamate antagonist in ischemia. J. Neurotrauma 8 (1991) 175-186
    • (1991) J. Neurotrauma , vol.8 , pp. 175-186
    • Kochhar, A.1    Zivin, J.A.2    Mazzarella, V.3
  • 19
    • 0024472706 scopus 로고
    • Memantine displaces [3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex
    • Kornhuber J., Bormann J., Retz W., Hubers M., and Riederer P. Memantine displaces [3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex. Eur. J. Pharmacol. 166 (1989) 589-590
    • (1989) Eur. J. Pharmacol. , vol.166 , pp. 589-590
    • Kornhuber, J.1    Bormann, J.2    Retz, W.3    Hubers, M.4    Riederer, P.5
  • 20
    • 30444457573 scopus 로고    scopus 로고
    • 3alpha-OL-5-beta-pregnan-20-one hemisuccinate, a steroidal low-affinity NMDA receptor antagonist improves clinical rating scores in a rabbit multiple infarct ischemia model: synergism with tissue plasminogen activator
    • Lapchak P.A. 3alpha-OL-5-beta-pregnan-20-one hemisuccinate, a steroidal low-affinity NMDA receptor antagonist improves clinical rating scores in a rabbit multiple infarct ischemia model: synergism with tissue plasminogen activator. Exp. Neurol. 197 (2006) 531-537
    • (2006) Exp. Neurol. , vol.197 , pp. 531-537
    • Lapchak, P.A.1
  • 21
    • 0042122368 scopus 로고    scopus 로고
    • Ebselen, a seleno-organic antioxidant, is neuroprotective after embolic strokes in rabbits: synergism with low-dose tissue plasminogen activator
    • Lapchak P.A., and Zivin J.A. Ebselen, a seleno-organic antioxidant, is neuroprotective after embolic strokes in rabbits: synergism with low-dose tissue plasminogen activator. Stroke 34 (2003) 2013-2018
    • (2003) Stroke , vol.34 , pp. 2013-2018
    • Lapchak, P.A.1    Zivin, J.A.2
  • 22
    • 0036098259 scopus 로고    scopus 로고
    • Neuroprotective effects of the spin trap agent disodium-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) in a rabbit small clot embolic stroke model: combination studies with the thrombolytic tissue plasminogen activator
    • Lapchak P.A., Araujo D.M., Song D., Wei J., and Zivin J.A. Neuroprotective effects of the spin trap agent disodium-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) in a rabbit small clot embolic stroke model: combination studies with the thrombolytic tissue plasminogen activator. Stroke 33 (2002) 1411-1415
    • (2002) Stroke , vol.33 , pp. 1411-1415
    • Lapchak, P.A.1    Araujo, D.M.2    Song, D.3    Wei, J.4    Zivin, J.A.5
  • 23
    • 0347624526 scopus 로고    scopus 로고
    • Comparison of tenecteplase with alteplase on clinical rating scores following small clot embolic strokes in rabbits
    • Lapchak P.A., Araujo D.M., and Zivin J.A. Comparison of tenecteplase with alteplase on clinical rating scores following small clot embolic strokes in rabbits. Exp. Neurol. 185 (2004) 154-159
    • (2004) Exp. Neurol. , vol.185 , pp. 154-159
    • Lapchak, P.A.1    Araujo, D.M.2    Zivin, J.A.3
  • 24
    • 3042706259 scopus 로고    scopus 로고
    • Coadministration of NXY-059 and tenecteplase six hours following embolic strokes in rabbits improves clinical rating scores
    • Lapchak P.A., Song D., Wei J., and Zivin J.A. Coadministration of NXY-059 and tenecteplase six hours following embolic strokes in rabbits improves clinical rating scores. Exp. Neurol. 188 (2004) 279-285
    • (2004) Exp. Neurol. , vol.188 , pp. 279-285
    • Lapchak, P.A.1    Song, D.2    Wei, J.3    Zivin, J.A.4
  • 25
    • 3242764671 scopus 로고    scopus 로고
    • Transcranial infrared laser therapy improves clinical rating scores after embolic strokes in rabbits
    • Lapchak P.A., Wei J., and Zivin J.A. Transcranial infrared laser therapy improves clinical rating scores after embolic strokes in rabbits. Stroke 35 (2004) 1985-1988
    • (2004) Stroke , vol.35 , pp. 1985-1988
    • Lapchak, P.A.1    Wei, J.2    Zivin, J.A.3
  • 26
    • 15044338779 scopus 로고    scopus 로고
    • Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults
    • Lipton S.A. Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults. NeuroRx 1 (2004) 101-110
    • (2004) NeuroRx , vol.1 , pp. 101-110
    • Lipton, S.A.1
  • 27
    • 13444291406 scopus 로고    scopus 로고
    • Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders
    • Lipton S.A. Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders. J. Alzheimer's Dis. 6 (2004) S61-S74
    • (2004) J. Alzheimer's Dis. , vol.6
    • Lipton, S.A.1
  • 28
    • 0141836222 scopus 로고    scopus 로고
    • Excitatory amino acid antagonists for acute stroke
    • (CD001244)
    • Muir K.W., and Lees K.R. Excitatory amino acid antagonists for acute stroke. Cochrane Database Syst. Rev. (2003) (CD001244)
    • (2003) Cochrane Database Syst. Rev.
    • Muir, K.W.1    Lees, K.R.2
  • 29
    • 0021260967 scopus 로고
    • Magnesium gates glutamate-activated channels in mouse central neurones
    • Nowak L., Bregestovski P., Ascher P., Herbet A., and Prochiantz A. Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307 (1984) 462-465
    • (1984) Nature , vol.307 , pp. 462-465
    • Nowak, L.1    Bregestovski, P.2    Ascher, P.3    Herbet, A.4    Prochiantz, A.5
  • 30
    • 0027731677 scopus 로고
    • Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)
    • Parsons C.G., Gruner R., Rozental J., Millar J., and Lodge D. Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan). Neuropharmacology 32 (1993) 1337-1350
    • (1993) Neuropharmacology , vol.32 , pp. 1337-1350
    • Parsons, C.G.1    Gruner, R.2    Rozental, J.3    Millar, J.4    Lodge, D.5
  • 31
    • 0029971255 scopus 로고    scopus 로고
    • Comparative patch-clamp studies with freshly dissociated rat hippocampal and striatal neurons on the NMDA receptor antagonistic effects of amantadine and memantine
    • Parsons C.G., Panchenko V.A., Pinchenko V.O., Tsyndrenko A.Y., and Krishtal O.A. Comparative patch-clamp studies with freshly dissociated rat hippocampal and striatal neurons on the NMDA receptor antagonistic effects of amantadine and memantine. Eur. J. Neurosci. 8 (1996) 446-454
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 446-454
    • Parsons, C.G.1    Panchenko, V.A.2    Pinchenko, V.O.3    Tsyndrenko, A.Y.4    Krishtal, O.A.5
  • 32
    • 0032892343 scopus 로고    scopus 로고
    • Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist-A review of preclinical data
    • Parsons C.G., Danysz W., and Quack G. Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist-A review of preclinical data. Neuropharmacology 38 (1999) 735-767
    • (1999) Neuropharmacology , vol.38 , pp. 735-767
    • Parsons, C.G.1    Danysz, W.2    Quack, G.3
  • 33
    • 0344065373 scopus 로고    scopus 로고
    • Recommendations for standards regarding preclinical neuroprotective and restorative drug development (STAIR)
    • Recommendations for standards regarding preclinical neuroprotective and restorative drug development (STAIR). Stroke 30 (1999) 2752-2758
    • (1999) Stroke , vol.30 , pp. 2752-2758
  • 34
    • 0034943173 scopus 로고    scopus 로고
    • Recommendations for clinical trial evaluation of acute stroke therapies (STAIR-II)
    • Recommendations for clinical trial evaluation of acute stroke therapies (STAIR-II). Stroke 32 (2001) 1598-1606
    • (2001) Stroke , vol.32 , pp. 1598-1606
  • 35
    • 1542314312 scopus 로고    scopus 로고
    • Memantine in moderate-to-severe Alzheimer disease evidence and ethics based?
    • (author reply 48)
    • Rikkert M.G., Dekkers W.J., Scheltens P., and Verhey F. Memantine in moderate-to-severe Alzheimer disease evidence and ethics based?. Alzheimer Dis. Assoc. Disord. 18 (2004) 47-48 (author reply 48)
    • (2004) Alzheimer Dis. Assoc. Disord. , vol.18 , pp. 47-48
    • Rikkert, M.G.1    Dekkers, W.J.2    Scheltens, P.3    Verhey, F.4
  • 36
    • 0141954291 scopus 로고    scopus 로고
    • The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease
    • Rogawski M.A., and Wenk G.L. The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. CNS Drug Rev. 9 (2003) 275-308
    • (2003) CNS Drug Rev. , vol.9 , pp. 275-308
    • Rogawski, M.A.1    Wenk, G.L.2
  • 37
    • 0022620257 scopus 로고
    • Glutamate and the pathophysiology of hypoxic-ischemic brain damage
    • Rothman S.M., and Olney J.W. Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann. Neurol. 19 (1986) 105-111
    • (1986) Ann. Neurol. , vol.19 , pp. 105-111
    • Rothman, S.M.1    Olney, J.W.2
  • 38
    • 0028872674 scopus 로고
    • Excitotoxicity and the NMDA receptor-Still lethal after eight years
    • Rothman S.M., and Olney J.W. Excitotoxicity and the NMDA receptor-Still lethal after eight years. Trends Neurosci. 18 (1995) 57-58
    • (1995) Trends Neurosci. , vol.18 , pp. 57-58
    • Rothman, S.M.1    Olney, J.W.2
  • 39
    • 0033019327 scopus 로고    scopus 로고
    • Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat
    • Stieg P.E., Sathi S., Warach S., Le D.A., and Lipton S.A. Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat. Eur. J. Pharmacol. 375 (1999) 115-120
    • (1999) Eur. J. Pharmacol. , vol.375 , pp. 115-120
    • Stieg, P.E.1    Sathi, S.2    Warach, S.3    Le, D.A.4    Lipton, S.A.5
  • 40
    • 0345872128 scopus 로고    scopus 로고
    • Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial
    • Tariot P.N., Farlow M.R., Grossberg G.T., Graham S.M., McDonald S., and Gergel I. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. JAMA 291 (2004) 317-324
    • (2004) JAMA , vol.291 , pp. 317-324
    • Tariot, P.N.1    Farlow, M.R.2    Grossberg, G.T.3    Graham, S.M.4    McDonald, S.5    Gergel, I.6
  • 41
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
    • Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N. Engl. J. Med. 333 (1995) 1581-1587
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1581-1587
  • 42
    • 0026696401 scopus 로고
    • Quantal bioassay and stroke
    • Zivin J.A., and Waud D.R. Quantal bioassay and stroke. Stroke 23 (1992) 767-773
    • (1992) Stroke , vol.23 , pp. 767-773
    • Zivin, J.A.1    Waud, D.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.