Nutrient-gene interactions in early pregnancy: A vascular hypothesis

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 106, Issue 2, 2003, Pages 115-117

  Steegers Theunissen, R P M ^a,b   Steegers, E A P ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Congenital malformations; Embryogenesis; Placental development; Preeclampsia

Indexed keywords

METHIONINE SYNTHASE; METHYLENETETRAHYDROFOLIC ACID;

ANGIOGENESIS; CARDIOVASCULAR DISEASE; DECIDUA; EMBRYO DEVELOPMENT; FERTILIZATION; FETUS GROWTH; FIRST TRIMESTER PREGNANCY; GAMETE; GENE INTERACTION; HUMAN; MATERNAL NUTRITION; NUTRIENT; NUTRITION; PARENT; PLACENTA DEVELOPMENT; PREGNANCY COMPLICATION; PRIORITY JOURNAL; REPRODUCTION; REVIEW; TROPHOBLAST; VASCULAR DISEASE;

EID: 0037428939     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-2115(02)00358-5     Document Type: Editorial

References (20)

1. Van Allen M.I. Fetal vascular disruptions: mechanisms and some resulting birth defects. Ped. Ann. 10:1981;219-235.
2. Barker DJP. Mothers, babies and health in later life. Edinburgh: Churchill Livingstone, 1998.
3. Goede V., Schmidt T., Kimmina S.et al. Analysis of bloodvessel maturation processes during cyclic ovarian angiogenesis. Lab Invest. 78:1998;1385-1394.
4. Dickens C.J., Maguiness S.D., Cromer M.T.et al. Human tubal fluid: formation and composition during vascular perfusion of the Fallopian tube. Hum. Reprod. 10:1995;230-236.
5. Cines D.B., Pollak E.S., Buck C.A., Loscalzo J., Zimmerman G.A., McEver R.P.et al. Endothelial cells in physiology and in the pathofysiology of vascular disorders. Blood. 91:1998;3527-3561.
6. Jauniaux E., Watson A.L., Hempstock J., Bao Y.P., Skepper J.N., Burton G.J. Onset of maternal arterial blood flow and placental oxidative stress. A possible factor in human early pregnancy failure. Am. J. Pathol. 157:2000;2111-2122.
7. McDowell I.F., Lang D. Homocysteine and endothelial dysfunction: a link with cardiovascular disease. J. Nutr. 130:2000;369S-372S.
8. Brauer P.R., Rosenquist T.H. Effect of elevated homocysteine on cardiac neural crest migration in vitro. Dev. Dyn. 224:2002;222-230.
9. Tsai J.C., Perrella M.A., Yoshizumi M., Hsieh C.M., Haber E., Schlegel R.et al. Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proc. Natl. Acad. Sci. U.S.A. 91:1994;6369-6373.
10. Wong W.Y., Merkus H.M., Thomas C.M., Menkveld R., Zielhuis G.A., Steegers-Theunissen R.P. Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial. Fertil. Steril. 77(3):2002;491-498.
11. O'Leary V.B., Parle-McDermott A., Molloy A.M., Kirke P.N., Johnson Z., Conley M.et al. MTRR and MTHFR polymorphism: link to Down syndrome. Am. J. Med. Genet. 107:2002;151-155.
12. Van der Put N.M.J., Steegers-Theunissen R.P.M., Frosst P.H.et al. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet. 2:1995;1070-1072.
13. Wenstrom K.D., DuBard M. Does a fetal neural tube or congenital heart defect indicate increased risk of maternal hypertension. Am. J. Obstet. Gynecol. 182:2000;S190.
14. Loscalzo J. Folate and nitrate-induced endothelial dysfunction. A simple treatment for a complex pathobiology. Circulation. 104:2001;1086-1088.
15. Steegers-Theunissen R.P.M., Smith S.C., Steegers E.A.P., Guilbert L., Baker P.N. Folate affects apoptosis in human trophoblasts. Br. J. Obstet. Gynaecol. 107:2000;1513-1515.
16. Cotter A.M., Nolloy A.M., Scott J.M., Daly S.F. Elevated plasma homocysteine in early pregnancy: a risk factor for the development of severe preeclampsia. Am. J. Obstet. Gynecol. 185:2001;781-785.
17. Leung D.N., Smith S.C., To K.F., Sahota D.S., Baker P.N. Increased placental apoptosis in pregnancies complicated by preeclampsia. Am. J. Obstet. Gynecol. 184:2001;1249-1250.
18. Kapusta L., Haagmans M.L., Steegers E.A., Cuypers M.H., Blom H.J., Eskes T.K. Congenital heart defects and maternal derangement of homocysteine metabolism. J. Pediatr. 135:1999;773-774.
19. McQuillan B.M., Beilby J.P., Nidorf M., Thompson P.L., Hung J. Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS). Circulation. 99:1999;1388-2383.
20. Smith S.K. Angiogenesis and reproduction. Br. J. Obstet. Gynaecol. 108:2002;777-783.