Use of pradofloxacin to treat experimentally induced Mycoplasma hemofelis infection in cats

American Journal of Veterinary Research

Volumn 70, Issue 1, 2009, Pages 105-111

  Dowers, Kristy L ^a   Tasker, Séverine ^b   Radecki, Steven V ^c   Lappin, Michael R ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE HYCLATE; GLUCOCORTICOID; PRADOFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG; VERAFLOX;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; CAT; CLINICAL FEATURE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; LOW DRUG DOSE; MALE; MYCOPLASMA HAEMOFELIS; NONHUMAN; POLYMERASE CHAIN REACTION;

ANEMIA; ANIMALS; ANTI-BACTERIAL AGENTS; BLOOD CELL COUNT; CAT DISEASES; CATS; DNA, BACTERIAL; DOXYCYCLINE; FEMALE; FLUOROQUINOLONES; HEMATOCRIT; MALE; MYCOPLASMA; MYCOPLASMA INFECTIONS; POLYMERASE CHAIN REACTION; RANDOM ALLOCATION; SPECIFIC PATHOGEN-FREE ORGANISMS;

ANIMALIA; MYCOPLASMA;

EID: 58549083398     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.70.1.105     Document Type: Article

References (31)

1. VanSteenhouse JL, Taboada J, Millard JR. Feline hemobartonellosis. Compend Contin Educ Pract Vet 1993;15:535-545.
2. Neimark H, Johansson KE, Rikihisa Y, et al. Proposal to transfer some members of the genera Haemobartonella and Eperythrozoon to the genus Mycoplasma with descriptions of 'Candidatus Mycoplasma haemofelis', 'Candidatus Mycoplasma haemomuris', ' Candidatus Mycoplasma haemosuis' and 'Candidatus Mycoplasma wenyoni.' Int Syst Evol Microbiol 2001;51:891-899.
3. Neimark H, Kocan KM. The cell wall-less rickettsia Eperythrozoon wenyonii is a Mycoplasma. FEMS Microbiol Lett 1997; 156:287-291.
4. Westfall DS, Jensen WA, Reagan WJ, et al. Inoculation of two genotypes of Hemobartonella felis (California and Ohio variants) to induce infection in cats and the response to treatment with azithromycin. Am J Vet Res 2001;62:687-691.
5. Lappin MR, Radecki S. Effects of imidocarb diproprionate in cats with chronic haemobartonellosis. Vet Ther 2002;3:144-149.
6. Dowers KL, Olver C, Radecki SV, et al. Use of enrofloxacin for treatment of large-form Haemobartonella felis in experimentally infected cats. J Am Vet Med Assoc 2002;221:250-253.
7. Ishak AM, Dowers KL, Cavanaugh MT, et al. Marbofloxacin for the treatment of experimentally-induced Mycoplasma haemofelis infection in cats. J Vet Intern Med 2008;22:288-292.
8. Tasker S, Carey SMA, Day MJ, et al. Effect of chronic FIV infection, and efficacy of marbofloxacin treatment, on Mycoplasma haemofelis infection. Vet Microbiol 2006;117:169-170.
9. Foley JE, Harrus S, Poland A, et al. Molecular, clinical, and pathologic comparison of two distinct strains of Haemobartonella felis in domestic cats. Am J Vet Res 1998;59:1581-1588.
10. Berent LM, Messick JB, Cooper SK. Detection of Haemobartonella felis in cats with experimentally induced acute and chronic infections, using a polymerase chain reaction assay. Am J Vet Res 1998;59:1215-1220.
11. Yamaguchi N, Macdonald DW, Passanisi WC, et al. Parasite prevalence in free-ranging farm cats, Felis silvestris catus. Epidemiol Infect 1996;116:217-223.
12. Luria BJ, Levy JK, Lappin MR, et al. Prevalence of infectious diseases in feral cats in Northern Florida. J Feline Med Surg 2004;6:287-296.
13. Ishak AM, Radecki S, Lappin MR. Prevalence of Mycoplasma haemofelis, 'Candidatus Mycoplasma haemominutum', Bartonella species, Ehrlichia species, and Anaplasma phagocytophilum DNA in the blood of cats with anemia. J Feline Med Surg 2007;9:1-7.
14. Criado-Fornelio A, Martinez-Marcos A, Buling-Saraña A, et al. Presence of Mycoplasma haemofelis, Mycoplasma haemominutum and piroplasmids in cats from southern Europe: a molecular study. Vet Microbiol 2003;93:307-317.
15. Bahri LE, Blouin A. Fluoroquinolones: a new family of antimicrobials. Compend Contin Educ Pract Vet 1991;13:1429-1433.
16. Riddle C, Lemons CL, Papich MG, et al. Evaluation of ciprofloxacin as a representative of veterinary fluoroquinolones in susceptibility testing. J Clin Microbiol 2000;38:1636-1637.
17. Silley P, Stephan B, Greife HA, et al. Comparative activity or pradofloxacin against anaerobic bacteria isolated from dogs and cats. J Antimicrob Chemother 2007;60:999-1003.
18. Wetzstein H-G. Comparative mutant prevention concentrations of pradofloxacin and other veterinary fluoroquinolones indicate differing potentials in preventing selection of resistance. Antimicrob Agents Chemother 2005;49:4166-4173.
19. Jensen WA, Lappin MR, Kamkar S, et al. Use of a polymerase chain reaction assay to detect and differentiate two strains of Haemobartonella felis in naturally infected cats. Am J Vet Res 2001;62:604-608.
20. Tasker S, Helps CR, Day MJ, et al. Use of real-time PCR to detect and quantify Mycoplasma haemofelis and 'Candidatus Mycoplasma haemominutum' DNA. J Clin Microbiol 2003;41:439-441.
21. Peterson LR. Quinolone molecular structure-activity relationships: what we have learned about improving antimicrobial activity. Clin Infect Dis 2001;33(suppl 3):S180-S186.
22. Drlica K, Malik M. Fluoroquinolones: action and resistance. Curr Top Med Chem 2003;3:249-282.
23. Tasker S, Helps CR, Day MJ, et al. Use of a Taqman PCR to determine the response of Mycoplasma haemofelis to antimicrobial treatment. J Microbiol Methods 2004;56:63-71.
24. Lappin MR, Griffin B, Brunt J, et al. Prevalence of Bartonella species, haemoplasma species, Ehrlichia species, Anaplasma phagocytophilum, and Neorickettsia risticii DNA in the blood of cats and their fleas in the United States. J Feline Med Surg 2006;8:85-90.
25. Maede Y. Sequestration and phagocytosis of Haemobartonella felis in the spleen. Am J Vet Res 1979;40:691-695.
26. Dietz BL. The fluoroquinolones. Clin Toxicol Rev [serial on-linel. 1997;20:1-2. Available at: www.maripoisoncenter.com/ctr/ 9712Fluoroquinolones.html. Jul 13, 2006.
27. Gelatt KN, van der Woerdt A, Ketring KL, et al. Enrofloxacin-associated retinal degeneration in cats. Vet Ophthalmol 2001;4:99-106.
28. Wiebe V, Hamilton P. Fluoroquinolone-induced retinal degeneration in cats. J Am Vet Med Assoc 2002;221:1568-1571.
29. Messias A, Gekeler F, Wegener A, et al. Retinal safety of a new fluoroquinolone, pradofloxacin, in cats: assessment with electro-retinography Doc Ophthalmol 2008;116:177-191.
30. Melendez LD, Twedt DC, Wright M. Suspected doxycycline induced esophagitis with esophageal stricture formation in three cats. Feline Pract 2000;28(2):10-12.
31. German AJ, Cannon MJ, Dye C, et al. Oesophageal strictures in cats associated with doxycycline therapy. J Fel Med Surg 2000;7:33-41.