Retinal safety of a new fluoroquinolone, pradofloxacin, in cats: Assessment with electroretinography

Documenta Ophthalmologica

Volumn 116, Issue 3, 2008, Pages 177-191

  Messias, Andre ^a   Gekeler, Florian ^a   Wegener, Alfred ^b   Dietz, Klaus ^a   Kohler, Konrad ^a   Zrenner, Eberhart ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Cat; Electroretinography; Enrofloxacin; Fluoroquinolone; Pradofloxacin; Retina; Toxicity

Indexed keywords

ENROFLOXACIN; PLACEBO; PRADOFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

A WAVE; AMPLITUDE MODULATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B WAVE; CAT; CONTROLLED STUDY; DARK ADAPTATION; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG SAFETY; ELECTRORETINOGRAPHY; EYE TOXICITY; FEMALE; HISTOPATHOLOGY; LUMINANCE; MALE; NIGHT VISION; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; OPTOMETRY; OSCILLATORY POTENTIAL; RETINA; TOXICITY TESTING; TREATMENT DURATION; VISUAL STIMULATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-BACTERIAL AGENTS; CATS; DARK ADAPTATION; ELECTRORETINOGRAPHY; FEMALE; FLUOROQUINOLONES; MALE; OSCILLOMETRY; PHOTORECEPTORS, VERTEBRATE; RETINA; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 42549160888     PISSN: 00124486     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10633-007-9081-x     Document Type: Article

References (36)

1. Wolfson JS, Hooper DC (1989) Fluoroquinolone antimicrobial agents. Clin Microbiol Rev 2:378-424
2. Mitsuhashi S, Hirai K (1992) Future prospects of quinolones. Prog Drug Res 38:145-147
3. Hooper DC, Wolfson JS (1985) The fluoroquinolones: Pharmacology, clinical uses, and toxicities in umans. Antimicrob Agents Chemother 28:716-721
4. Wetzstein HG (2005) Comparative mutant prevention concentrations of pradofloxacin and other veterinary fluoroquinolones indicate differing potentials in preventing selection of resistance. Antimicrob Agents Chemother 49:4166-4173
5. Mueller RS, Stephan B (2007) Pradofloxacin in the treatment of canine deep pyoderma: A multicentred, blinded, randomized parallel trial. Vet Dermatol 18:144-151
6. Schroder J (1989) Enrofloxacin: A new antimicrobial agent. J S Afr Vet Assoc 60:122-124
7. Wiebe V, Hamilton P (2002) Fluoroquinolone-induced retinal degeneration in cats. J Am Vet Med Assoc 221:1568-1571
8. Gelatt KN, van der WA, Ketring KL et al (2001) Enrofloxacin-associated retinal degeneration in cats. Vet Ophthalmol 4:99-106
9. Ford MM, Dubielzig RR, Giuliano EA et al (2007) Ocular and systemic manifestations after oral administration of a high dose of enrofloxacin in cats. Am J Vet Res 68:190-202
10. Wiechens B, Grammer JB, Johannsen U et al (1999) Experimental intravitreal application of ciprofloxacin in rabbits. Ophthalmologica 213:120-128
11. Sakai H, Mochizuki K, Torisaki M et al (1994) Nontoxic intravitreal dose of ofloxacin for rabbit retina. Ophthalmic Res 26:344-351
12. Cohen RG, Raizman M, Callina C, Lahav M (1997) Retinal safety of oral and topical ofloxacin in rabbits. J Ocul Pharmacol Ther 13:369-379
13. Gurler B, Ozkul Y, Bitiren M et al (2002) A study on the toxicity of intravitreal levofloxacin in rabbits. Curr Eye Res 24:253-262
14. Mochizuki K, Higashide T, Torisaki M et al (1995) Effects of norfloxacin on the retina in rabbits. Graefes Arch Clin Exp Ophthalmol 233:173-180
15. Gurler B, Ozkul Y, Bitiren M et al (2001) Experimental intravitreal application of trovafloxacin in rabbits. Ophthalmic Res 33:228-236
16. Aydin E, Kazi AA, Peyman GA, Esfahani MR (2006) Intravitreal toxicity of moxifloxacin. Retina 26:187-190
17. Esfahani MR, Kazi AA, Peyman GA et al (2006) Intravitreal toxicity of garenoxacin. Retina 26:182-186
18. Hobbs HE, Sorsby A, Freedman A (1959) Retinopathy following chloroquine therapy. Lancet 2:478-480
19. Fukuda M, Sasaki K (1989) Intraocular dynamic mode differences of new quinolone antibacterial agents between pigmented and albino rabbit eyes. Lens Eye Toxic Res 6:339-351
20. Fukuda M, Morita Y, Sasaki K, Yamamoto Y (2000) Studies on the binding mechanism of fluoroquinolones to melanin. J Infect Chemother 6:72-76
21. Siefert HM, Kohlsdorfer C, Steinke W, Witt A (1999) Pharmacokinetics of the 8-methoxyquinolone, moxifloxacin: Tissue distribution in male rats. J Antimicrob Chemother 43 (Suppl B):61-67
22. Ono C, Tanaka M (2003) Binding characteristics of fluoroquinolones to synthetic levodopa melanin. J Pharm Pharmacol 55:1127-1233
23. Gao H, Pennesi ME, Qiao X et al (2006) Intravitreal moxifloxacin: retinal safety study with electroretinography and histopathology in animal models. Invest Ophthalmol Vis Sci 47:1606-1611
24. Endophthalmitis Vitrectomy Study Group (1995) Results of the Endophthalmitis Vitrectomy Study. A randomized trial of immediate vitrectomy and of intravenous antibiotics for the treatment of postoperative bacterial endophthalmitis. Arch Ophthalmol 113:1479-1496
25. Campochiaro PA, Conway BP (1991) Aminoglycoside toxicity - a survey of retinal specialists. Implications for ocular use. Arch Ophthalmol 109:946-950
26. Marmor MF, Zrenner E (1998) Standard for clinical electroretinography (1999 update). International Society for Clinical Electrophysiology of Vision. Doc Ophthalmol 97:143-156
27. Naka KI, Rushton WA (1966) S-potentials from luminosity units in the retina of fish (Cyprinidae). J Physiol 185:587-599
28. Lamb TD, Pugh EN Jr (1992) A quantitative account of the activation steps involved in phototransduction in amphibian photoreceptors. J Physiol 449:719-758
29. Giuliano EA, van der WA (1999) Feline retinal degeneration: Clinical experience and new findings (1994-1997). J Am Anim Hosp Assoc 35:511-514
30. Boke W, Baumer A, Muller-Limmroth W, Mludek M (1967) On the problem of chloroquine damage to the eye. Klin Monatsbl Augenheilkd 151:617-633
31. Marmor MF, Carr RE, Easterbrook M et al (2002) Recommendations on screening for chloroquine and hydroxychloroquine retinopathy: A report by the American Academy of Ophthalmology. Ophthalmology 109:1377-1382
32. Leblanc B, Jezequel S, Davies T et al (1998) Binding of drugs to eye melanin is not predictive of ocular toxicity. Regul Toxicol Pharmacol 28:124-132
33. Duncker G, Bredehorn T (1996) Chloroquine-induced lipidosis in the rat retina: Functional and morphological changes after withdrawal of the drug. Graefes Arch Clin Exp Ophthalmol 234:378-381
34. Akahane K, Kimura Y, Tsutomi Y, Hayakawa I (1994) Possible intermolecular interaction between quinolones and biphenylacetic acid inhibits gamma-aminobutyric acid receptor sites. Antimicrob Agents Chemother 38:2323-2329
35. Akahane K, Sekiguchi M, Une T, Osada Y (1989) Structure-epileptogenicity relationship of quinolones with special reference to their interaction with gamma-aminobutyric acid receptor sites. Antimicrob Agents Chemother 33:1704-1708
36. Schmuck G, Schurmann A, Schluter G (1998) Determination of the excitatory potencies of fluoroquinolones in the central nervous system by an in vitro model. Antimicrob Agents Chemother 42:1831-1836