Characterization in vivo of bilaterally branching pontocerebellar mossy fibre to Golgi cell inputs in the rat cerebellum

European Journal of Neuroscience

Volumn 29, Issue 2, 2009, Pages 328-339

  Holtzman, Tahl ^a   Cerminara, Nadia L ^b   Edgley, Steve A ^a   Apps, Richard ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b SCHOOL OF MEDICAL SCIENCES   (United Kingdom)

Author keywords

Bilateral; Cerebellum; Golgi cell; Mossy fibre; Pontine nucleus

Indexed keywords

URETHAN;

ANIMAL EXPERIMENT; ARTICLE; BRAIN FUNCTION; CEREBELLUM CORTEX; CONTROLLED STUDY; GOLGI COMPLEX; HEMISPHERE; IN VIVO STUDY; MOSSY FIBER; NONHUMAN; OUTCOME ASSESSMENT; PONS ANGLE; POSITIVE FEEDBACK; PRIORITY JOURNAL; PURKINJE CELL; RAT; SPIKE WAVE;

ACTION POTENTIALS; ANIMALS; BRAIN MAPPING; CEREBELLAR CORTEX; FLUORESCENT DYES; FUNCTIONAL LATERALITY; INTERNEURONS; MALE; MICROSPHERES; NERVE FIBERS; NEURAL INHIBITION; NEURAL PATHWAYS; RATS; RATS, WISTAR; REACTION TIME; STAINING AND LABELING; SYNAPSES;

EID: 58449104754     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2008.06572.x     Document Type: Article

References (45)

1. Bagshaw, E.V. Evans, M.H. (1976) Measurement of current spread from microelectrodes when stimulating within the nervous system. Exp. Brain Res., 25, 391 400.
2. Baker, M.R. Edgley, S.A. (2006) Non-uniform olivocerebellar conduction time in the vermis of the rat cerebellum. J. Physiol., 570, 501 506.
3. Bhumbra, G.S. Dyball, R.E. (2004) Measuring spike coding in the rat supraoptic nucleus. J. Physiol., 555, 281 296.
4. Brodal, P. Bjaalie, J.G. (1997) Salient anatomic features of the cortico-ponto-cerebellar pathway. Prog. Brain Res., 114, 227 249.
5. Campbell, N.C. Armstrong, D.M. (1983) The olivocerebellar projection in the rat: an autoradiographic study. Brain Res., 275, 215 233.
6. Chadderton, P., Margrie, T.W. Hausser, M. (2004) Integration of quanta in cerebellar granule cells during sensory processing. Nature, 428, 856 860.
7. Chen, S. Aston-Jones, G. (1998) Axonal collateral-collateral transport of tract tracers in brain neurons: false anterograde labelling and useful tool. Neuroscience, 82, 1151 1163.
8. De Schutter, E., Vos, B. Maex, R. (2000) The function of cerebellar Golgi cells revisited. Prog. Brain Res., 124, 81 93.
9. Eccles, J.C., Sasaki, K. Strata, P. (1967a) A comparison of the inhibitory actions of golgi cells and of basket cells. Exp. Brain Res., 3, 81 94.
10. Eccles, J.C., Sasaki, K. Strata, P. (1967b) Interpretation of the potential fields generated in the cerebellar cortex by a mossy fibre volley. Exp. Brain Res., 3, 58 80.
11. Edgley, S.A. Lidierth, M. (1987) The discharges of cerebellar Golgi cells during locomotion in the cat. J. Physiol., 392, 315 332.
12. Forti, L., Cesana, E., Mapelli, J. D'Angelo, E. (2006) Ionic mechanisms of autorhythmic firing in cerebellar Golgi cells. J. Physiol., 574, 711 729.
13. Hamori, J. Szentagothai, J. (1966) Participation of Golgi neuron processes in the cerebellar glomeruli: an electron microscope study. Exp. Brain Res., 2, 35 48.
14. Hartmann, M.J. Bower, J.M. (1998) Oscillatory activity in the cerebellar hemispheres of unrestrained rats. J. Neurophysiol., 80, 1598 1604.
15. Herrero, L., Pardoe, J. Apps, R. (2002) Pontine and lateral reticular projections to the c1 zone in lobulus simplex and paramedian lobule of the rat cerebellar cortex. Cerebellum, 1, 185 199.
16. Holtzman, T., Mostofi, A., Phuah, C. Edgley, S. (2006a) Cerebellar Golgi cells receive multi-modal convergent peripheral inputs via the lateral funiculus of the spinal cord. J. Physiol., 577, 69 80.
17. Holtzman, T., Rajapaksa, T., Mostofi, A. Edgley, S.A. (2006b) Different responses of rat cerebellar Golgi cell and Purkinje cells evoked by somatosensory afferent inputs. J. Physiol., 574, 491 507.
18. Ito, M., Kawai, N., Udo, M. Mano, N. (1969) Axon reflex activation of deiters neurones from the cerebellar cortex through collaterals of the cerebellar afferents. Exp. Brain Res., 8, 249 268.
19. Jankowska, E. Roberts, W.J. (1972) An electrophysiological demonstration of the axonal projections of single spinal interneurones in the cat. J. Physiol., 222, 597 622.
20. Jorntell, H. Ekerot, C.F. (2006) Properties of somatosensory synaptic integration in cerebellar granule cells in vivo. J. Neurosci., 26, 11786 11797.
21. Kosinski, R.J., Azizi, S.A., Border, B.G. Mihailoff, G.A. (1986) Origin and ultrastructural identification of dorsal column nuclear synaptic terminals in the basilar pontine gray of rats. J. Comp. Neurol., 253, 92 104.
22. Maex, R. Schutter, E.D. (1998) Synchronization of golgi and granule cell firing in a detailed network model of the cerebellar granule cell layer. J. Neurophysiol., 80, 2521 2537.
23. Menetrey, D., de Pommery, J. Besson, J.M. (1984) Electrophysiological characteristics of lumbar spinal cord neurons backfired from lateral reticular nucleus in the rat. J. Neurophysiol., 52, 595 611.
24. Mihailoff, G.A. (1983) Intra- and interhemispheric collateral branching in the rat pontocerebellar system, a fluorescence double-label study. Neuroscience, 10, 141 160.
25. Mihailoff, G.A., Kosinski, R.J., Azizi, S.A. Border, B.G. (1989) Survey of noncortical afferent projections to the basilar pontine nuclei: a retrograde tracing study in the rat. J. Comp. Neurol., 282, 617 643.
26. Palay, S.L. Chan-Palay, V. (1974). Cerebellar cortex: cytology and organisation. Springer Verlag, New York, Heidelberg, Berlin.
27. Payne, J.N. (1983) Axonal branching in the projections from precerebellar nuclei to the lobulus simplex of the rat's cerebellum investigated by retrograde fluorescent double labeling. J. Comp. Neurol., 213, 233 240.
28. Peeters, R.R., Verhoye, M., Vos, B.P., Van Dyck, D., Van Der Linden, A. De Schutter, E. (1999) A patchy horizontal organization of the somatosensory activation of the rat cerebellum demonstrated by functional MRI. Eur. J. Neurosci., 11, 2720 2730.
29. Pijpers, A., Apps, R., Pardoe, J., Voogd, J. Ruigrok, T.J. (2006) Precise spatial relationships between mossy fibers and climbing fibers in rat cerebellar cortical zones. J. Neurosci., 26, 12067 12080.
30. Precht, W. Llinas, R. (1969) Functional organization of the vestibular afferents to the cerebellar cortex of frog and cat. Exp. Brain Res., 9, 30 52.
31. Rancz, E.A., Ishikawa, T., Duguid, I., Chadderton, P., Mahon, S. Hausser, M. (2007) High-fidelity transmission of sensory information by single cerebellar mossy fibre boutons. Nature, 450, 1245 1248.
32. Rosina, A. Provini, L. (1984) Pontocerebellar system linking the two hemispheres by intracerebellar branching. Brain Res., 296, 365 369.
33. Sasaki, K. Strata, P. (1967) Responses evoked in the cerebellar cortex by stimulating mossy fibre pathways to the cerebellum. Exp. Brain Res., 3, 95 110.
34. Schulman, J.A. Bloom, F.E. (1981) Golgi cells of the cerebellum are inhibited by inferior olive activity. Brain Res., 210, 350 355.
35. Serapide, M.F., Panto, M.R., Parenti, R., Zappala, A. Cicirata, F. (2001) Multiple zonal projections of the basilar pontine nuclei to the cerebellar cortex of the rat. J. Comp. Neurol., 430, 471 484.
36. Serapide, M.F., Parenti, R., Panto, M.R., Zappala, A. Cicirata, F. (2002) Multiple zonal projections of the nucleus reticularis tegmenti pontis to the cerebellar cortex of the rat. Eur. J. Neurosci., 15, 1854 1858.
37. Shambes, G.M., Gibson, J.M. Welker, W. (1978) Fractured somatotopy in granule cell tactile areas of rat cerebellar hemispheres revealed by micromapping. Brain Behav. Evol., 15, 94 140.
38. Simpson, J.I., Hulscher, H.C., Sabel-Goedknegt, E. Ruigrok, T.J. (2005) Between in and out: linking morphology and physiology of cerebellar cortical interneurons. Prog. Brain Res., 148, 329 340.
39. Swenson, R.S., Kosinski, R.J. Castro, A.J. (1984) Topography of spinal, dorsal column nuclear, and spinal trigeminal projections to the pontine gray in rats. J. Comp. Neurol., 222, 301 311.
40. Tahon, K., Volny-Luraghi, A. De Schutter, E. (2005) Temporal characteristics of tactile stimuli influence the response profile of cerebellar Golgi cells. Neurosci. Lett., 390, 156 161.
41. Vos, B.P., Volny-Luraghi, A. De Schutter, E. (1999) Cerebellar Golgi cells in the rat: receptive fields and timing of responses to facial stimulation. Eur. J. Neurosci., 11, 2621 2634.
42. Vos, B.P., Volny-Luraghi, A., Maex, R. De Schutter, E. (2000) Precise spike timing of tactile-evoked cerebellar Golgi cell responses: a reflection of combined mossy fiber and parallel fiber activation? Prog. Brain Res., 124, 95 106.
43. Woolston, D.C., Kassel, J. Gibson, J.M. (1981) Trigeminocerebellar mossy fiber branching to granule cell layer patches in the rat cerebellum. Brain Res., 209, 255 269.
44. Wu, H.S., Sugihara, I. Shinoda, Y. (1999) Projection patterns of single mossy fibers originating from the lateral reticular nucleus in the rat cerebellar cortex and nuclei. J. Comp. Neurol., 411, 97 118.
45. Yamamoto, T., Fukuda, M. Llinas, R. (2001) Bilaterally synchronous complex spike Purkinje cell activity in the mammalian cerebellum. Eur. J. Neurosci., 13, 327 339.