CXCR-4 knockdown by small interfering RNA inhibits cell proliferation and invasion of oral squamous cell carcinoma cells

Journal of Oral Pathology and Medicine

Volumn 38, Issue 2, 2009, Pages 214-219

  Hong, Ji Soo ^a   Pai, Hyun Kyung ^a   Hong, Kyoung Ok ^a   Kim, Mi Ae ^a   Kim, Ji Hong ^a   Lee, Jae Il ^a   Hong, Sam Pyo ^a   Hong, Seong Doo ^a  

^a Seoul National University   (South Korea)

Author keywords

CXCR 4 knockdown; Invasion; Oral squamous cell carcinoma; Proliferation; SiRNA

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; SMALL INTERFERING RNA;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MOUTH CARCINOMA; ORAL SQUAMOUS CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; CLONE CELLS; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOBLOTTING; LYMPHATIC METASTASIS; MOUTH NEOPLASMS; NEOPLASM INVASIVENESS; PROLIFERATING CELL NUCLEAR ANTIGEN; RECEPTORS, CXCR4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING;

EID: 58449097297     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2008.00671.x     Document Type: Article

References (25)

1. Massano J, Regateiro FS, Januário G, Ferreira A. Oral squamous cell carcinoma: review of prognostic and predictive factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006 102 : 67 76.
2. Ossoff R, Sisson G. Lymphatics of the floor of the mouth and neck: anatomical studies related to contralateral drainage pathways. Laryngoscope 1981 91 : 1847 50.
3. Takes RP, Baatenburg de Jong RJ, Alles MJ, et al. Markers for nodal metastasis in head and neck squamous cell cancer. Arch Otolaryngol Head Neck Surg 2002 128 : 512 8.
4. Schmalbach CE, Chepeha DB, Giordano TJ, et al. Molecular profiling and the identification of genes associated with metastatic oral cavity/pharynx squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2004 130 : 295 302.
5. Moser B, Loetscher P. Lymphocyte traffic control by chemokines. Nat Immunol 2001 2 : 123 8.
6. Gupta SK, Lysko PG, Pillarisetti K, Ohlstein E, Stadel JM. Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines. J Biol Chem 1998 273 : 4282 7.
7. Nakajima T, Tachibana K, Iizasa H, et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Proc Natl Acad Sci USA 1996 93 : 14726 9.
8. Bennett I, Cronholm P, Ochroch A, Taichman D, Taichman R. Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. J Urol 2002 168 : 203 4.
9. Schrader AJ, Lechner O, Templin M, et al. CXCR4/CXCL12 expression and signalling in kidney cancer. Br J Cancer 2002 86 : 1250 6.
10. Geminder H, Sagi-Assif O, Goldberg L, et al. A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma. J Immunol 2001 167 : 4747 57.
11. Muller A, Homey B, Soto H, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001 410 : 50 6.
12. Murakami T, Maki W, Cardones AR, et al. Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells. Cancer Res 2002 62 : 7328 34.
13. Almofti A, Uchida D, Begum NM, et al. The clinicopathological significance of the expression of CXCR4 protein in oral squamous cell carcinoma. Int J Oncol 2004 25 : 65 71.
14. Ishikawa T, Nakashiro K, Hara S, et al. CXCR4 expression is associated with lymph-node metastasis of oral squamous cell carcinoma. Int J Oncol 2006 28 : 61 6.
15. Doench JG, Petersen CP, Sharp PA. siRNAs can function as miRNAs. Genes Dev 2003 17 : 438 42.
16. Chen Y, Stamatoyannopoulos G, Song CZ. Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro. Cancer Res 2003 63 : 4801 4.
17. Smith MC, Luker KE, Garbow JR, et al. CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res 2004 64 : 8604 12.
18. Lapteva N, Yang AG, Sanders DE, Strube RW, Chen SY. CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo. Cancer Gene Ther 2005 12 : 84 9.
19. Guleng B, Tateishi K, Ohta M, et al. Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res 2005 65 : 5864 71.
20. Lee G, Kim YB, Kim JH, et al. Characterization of novel cell lines established from three human oral squamous cell carcinomas. Int J Oncol. 2002 20 : 1151 9.
21. Jiang WG, Hiscox S, Hallett MB, Horrobin DF, Mansel RE, Puntis MCA. Regulation of the expression of E-cadherin on human cancer cells by gamma linolenic acid. Cancer Res 1995 55 : 5043 8.
22. Hong SD, Hong SP, Lee JI, Lim CY. Expression of matrix metalloproteinase-2 and -9 in oral squamous cell carcinomas with regard to the metastatic potential. Oral Oncol 2000 36 : 207 13.
23. Lim J, Kim JH, Paeng JY, et al. Prognostic value of activated Akt expression in oral squamous cell carcinoma. J Clin Pathol 2005 58 : 1199 205.
24. Bachelder R, Wendt M, Mercurio A. Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res 2002 62 : 7203 6.
25. Hall JM, Korach KS. Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells. Mol Endocrinol 2003 17 : 792 803.