Neutrophils are essential for rapid clearance of Enterococcus faecium in mice

Infection and Immunity

Volumn 77, Issue 1, 2009, Pages 485-491

  Leendertse, Masja ^a,b   Willems, Rob J L ^b   Giebelen, Ida A J ^a   Roelofs, Joris J T H ^a   Bonten, Marc J M ^b   Van Der Poll, Tom ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE PHASE PROTEIN; AMYLOID A PROTEIN; COMPLEMENT COMPONENT C3; IMMUNOGLOBULIN G; INTERLEUKIN 6; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY RB6 8C5; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTEREMIA; BACTERIAL GROWTH; BACTERIUM CULTURE; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENTEROCOCCUS FAECIUM; FEMALE; MACROPHAGE; MOUSE; NEUTROPENIA; NEUTROPHIL; NONHUMAN; PERITONITIS; PRIORITY JOURNAL;

ANIMALS; ASCITIC FLUID; BACTEREMIA; BLOOD; COLONY COUNT, MICROBIAL; CYTOKINES; ENTEROCOCCUS FAECIUM; FEMALE; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; LEUKOCYTE COUNT; LEUKOCYTE REDUCTION PROCEDURES; LIVER; LUNG; MICE; NEUTROPHILS; PERITONITIS;

EID: 58449085560     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00863-08     Document Type: Article

References (47)

1. Arduino, R. C., K. Jacques-Palaz, B. E. Murray, and R. M. Rakita. 1994. Resistance of Enterococcus faecium to neutrophil-mediated phagocytosis. Infect. Immun. 62:5587-5594.
2. Arduino, R. C., B. E. Murray, and R. M. Rakita. 1994. Roles of antibodies and complement in phagocytic killing of enterococci. Infect. Immun. 62:987-993.
3. Barsig, J., D. S. Bundschuh, T. Hartung, A. Bauhofer, A. Sauer, and A. Wendel. 1996. Control of fecal peritoneal infection in mice by colony-stimulating factors. J. Infect. Dis. 174:790-799.
4. Bliss, S. K., L. C. Gavrilescu, A. Alcaraz, and E. Y. Denkers. 2001. Neutrophil depletion during Toxoplasma gondii infection leads to impaired immunity and lethal systemic pathology. Infect. Immun. 69:4898-4905.
5. Bonten, M. J., R. Willems, and R. A. Weinstein. 2001. Vancomycin-resistant enterococci: why are they here, and where do they come from? Lancet Infect. Dis. 1:314-325.
6. Caballero-Granado, F. J., B. Becerril, J. M. Cisneros, L. Cuberos, I. Moreno, and J. Pachon. 2001. Case-control study of risk factors for the development of enterococcal bacteremia. Eur. J. Clin. Microbiol. Infect. Dis. 20:83-90.
7. Caballero-Granado, F. J., B. Becerril, L. Cuberos, M. Bernabeu, J. M. Cisneros, and J. Pachon. 2001. Attributable mortality rate and duration of hospital stay associated with enterococcal bacteremia. Clin. Infect. Dis. 32:587-594.
8. Conlan, J. W., R. KuoLee, H. Shen, and A. Webb. 2002. Different host defences are required to protect mice from primary systemic vs pulmonary infection with the facultative intracellular bacterial pathogen, Francisella tularensis LVS. Microb. Pathog. 32:127-134.
9. Conlan, J. W., and R. J. North. 1994. Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody. J. Exp. Med. 179:259-268.
10. Daley, J. M., A. A. Thomay, M. D. Connolly, J. S. Reichner, and J. E. Albina. 2008. Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice. J. Leukoc. Biol. 83:64-70.
11. Dalrymple, S. A., R. Slattery, D. M. Aud, M. Krishna, L. A. Lucian, and R. Murray. 1996. Interleukin-6 is required for a protective immune response to systemic Escherichia coli infection. Infect. Immun. 64:3231-3235.
12. Fleming, T. J., M. L. Fleming, and T. R. Malek. 1993. Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family. J. Immunol. 151:2399-2408.
13. Goossens, H. 1999. The epidemiology of vancomycin-resistant enterococci. Curr. Opin. Infect. Dis. 12:537-541.
14. Goossens, P. L., H. Jouin, and G. Milon. 1991. Dynamics of lymphocytes and inflammatory cells recruited in liver during murine listeriosis. A cytofluorimetric study. J. Immunol. 147:3514-3520.
15. Harvey, B. S., C. J. Baker, and M. S. Edwards. 1992. Contributions of complement and immunoglobulin to neutrophil-mediated killing of enterococci. Infect. Immun. 60:3635-3640.
16. Hendrickx, A. P., W. J. van Wamel, G. Posthuma, M. J. Bonten, and R. J. Willems. 2007. Five genes encoding surface-exposed LPXTG proteins are enriched in hospital-adapted Enterococcus faecium clonal complex 17 isolates. J. Bacteriol. 189:8321-8332.
17. LaFleur, A. M., N. W. Lukacs, S. L. Kunkel, and A. Matsukawa. 2004. Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis. Mediators Inflamm. 13:349-355.
18. Lautenbach, E., W. B. Bilker, and P. J. Brennan. 1999. Enterococcal bacteremia: risk factors for vancomycin resistance and predictors of mortality. Infect. Control Hosp. Epidemiol. 20:318-323.
19. Leavis, H., J. Top., N. Shankar, K. Borgen, M. Bonten, J. van Embden, and R. J. Willems. 2004. A novel putative enterococcal pathogenicity island linked to the esp virulence gene of Enterococcus faecium and associated with epidemicity. J. Bacteriol. 186:672-682.
20. Leavis, H. L., M. J. Bonten, and R. J. Willems. 2006. Identification of high-risk enterococcal clonal complexes: global dispersion and antibiotic resistance. Curr. Opin. Microbiol. 9:454-460.
21. Leavis, H. L., R. J. Willems, W. J. van Wamel, F. H. Schuren, M. P. Caspers, and M. J. Bonten. 2007. Insertion sequence-driven diversification creates a globally dispersed emerging multiresistant subspecies of E. faecium. PLoS Pathog. 3:e7.
22. Leendertse, M., R. J. Willems, I. A. Giebelen, P. S. van den Pangaart, W. J. Wiersinga, A. F. de Vos, S. Florquin, M. J. Bonten, and T. van der Poll. 2008. TLR2-dependent MyD88 signaling contributes to early host defense in murine Enterococcus faecium peritonitis. J. Immunol. 180:4865-4874.
23. Malani, P. N., C. A. Kauffman, and M. J. Zervos. 2002. Enterococcal disease, epidemiology, and treatment. ASM Press, Washington, DC.
24. Marks, M., T. Burns, M. Abadi, B. Seyoum, J. Thornton, E. Tuomanen, and L. A. Pirofski. 2007. Influence of neutropenia on the course of serotype 8 pneumococcal pneumonia in mice. Infect. Immun. 75:1586-1597.
25. Mayer-Scholl, A., P. Averhoff, and A. Zychlinsky. 2004. How do neutrophils and pathogens interact? Curr. Opin. Microbiol. 7:62-66.
26. Mednick, A. J., M. Feldmesser, J. Rivera, and A. Casadevall. 2003. Neutropenia alters lung cytokine production in mice and reduces their susceptibility to pulmonary cryptococcosis. Eur. J. Immunol. 33:1744-1753.
27. Medzhitov, R., and C. Janeway, Jr. 2000. Innate immunity. N. Engl. J. Med. 343:338-344.
28. Ness, T. L., C. M. Hogaboam, R. M. Strieter, and S. L. Kunkel. 2003. Immunomodulatory role of CXCR2 during experimental septic peritonitis. J. Immunol. 171:3775-3784.
29. Noskin, G. A., L. R. Peterson, and J. R. Warren. 1995. Enterococcus faecium and Enterococcus faecalis bacteremia: acquisition and outcome. Clin. Infect. Dis. 20:296-301.
30. Onyeji, C. O., K. Q. Bui, D. P. Nicolau, C. H. Nightingale, L. Bow, and R. Quintiliani. 1999. Influence of adjunctive interferon-gamma on treatment of gentamicin- and vancomycin-resistant Enterococcus faecalis infection in mice. Int. J. Antimicrob. Agents 12:301-309.
31. Onyeji, C. O., D. P. Nicolau, C. H. Nightingale, and L. Bow. 2000. Modulation of efficacies and pharmacokinetics of antibiotics by granulocyte colonystimulating factor in neutropenic mice with multidrug-resistant Enterococcus faecalis infection. J. Antimicrob. Chemother. 46:429-436.
32. Renckens, R., J. J. Roelofs, V. de Waard, S. Florquin, H. R. Lijnen, P. Carmeliet, and T. van der Poll. 2005. The role of plasminogen activator inhibitor type 1 in the inflammatory response to local tissue injury. J. Thromb. Haemost. 3:1018-1025.
33. Renckens, R., J. J. Roelofs, S. Florquin, A. F. de Vos, H. R. Lijnen, C. van't Veer, and T. van der Poll. 2006. Matrix metalloproteinase-9 deficiency impairs host defense against abdominal sepsis. J. Immunol. 176:3735-3741.
34. Schaberg, D. R., D. H. Culver, and R. P. Gaynes. 1991. Major trends in the microbial etiology of nosocomial infection. Am. J. Med. 91:72S-75S.
35. Sjöstedt, A., J. W. Conlan, and R. J. North. 1994. Neutrophils are critical for host defense against primary infection with the facultative intracellular bacterium Francisella tularensis in mice and participate in defense against reinfection. Infect. Immun. 62:2779-2783.
36. Tateda, K., T. A. Moore, J. C. Deng, M. W. Newstead, X. Zeng, A. Matsukawa, M. S. Swanson, K. Yamaguchi, and T. J. Standiford. 2001. Early recruitment of neutrophils determines subsequent T1/T2 host responses in a murine model of Legionella pneumophila pneumonia. J. Immunol. 166:3355-3361.
37. Tenover, F. C., and L. C. McDonald. 2005. Vancomycin-resistant staphylococci and enterococci: epidemiology and control. Curr. Opin. Infect. Dis. 18:300-305.
38. Tepper, R. I., R. L. Coffman, and P. Leder. 1992. An eosinophil-dependent mechanism for the antitumor effect of interleukin-4. Science 257:548-551.
39. Top, J., R. Willems, H. Blok, M. de Regt, K. Jalink, A. Troelstra, B. Goorhuis, and M. Bonten. 2007. Ecological replacement of Enterococcus faecalis by multiresistant clonal complex 17 Enterococcus faecium. Clin. Microbiol. Infect. 13:316-319.
40. Treitman, A. N., P. R. Yarnold, J. Warren, and G. A. Noskin. 2005. Emerging incidence of Enterococcus faecium among hospital isolates (1993 to 2002). J. Clin. Microbiol. 43:462-463.
41. + T cell responses to bacterial antigens. J. Immunol. 173:1994-2002.
42. van Faassen, H., R. KuoLee, G. Harris, X. Zhao, J. W. Conlan, and W. Chen. 2007. Neutrophils play an important role in host resistance to respiratory infection with Acinetobacter baumannii in mice. Infect. Immun. 75:5597-5608.
43. Venditti, M., A. Tarasi, U. Visco Comandini, G. Gentile, C. Girmenia, A. Micozzi, and P. Martino. 1993. Enterococcal septicemia in patients with hematological malignancies. Eur. J. Clin. Microbiol. Infect. Dis. 12:241-247.
44. Walley, K. R., N. W. Lukacs, T. J. Standiford, R. M. Strieter, and S. L. Kunkel. 1997. Elevated levels of macrophage inflammatory protein 2 in severe murine peritonitis increase neutrophil recruitment and mortality. Infect. Immun. 65:3847-3851.
45. Weiss, S. J. 1989. Tissue destruction by neutrophils. N. Engl. J. Med. 320:365-376.
46. Witko-Sarsat, V., P. Rieu, B. Descamps-Latscha, P. Lesavre, and L. Halbwachs-Mecarelli. 2000. Neutrophils: molecules, functions and pathophysiological aspects. Lab. Invest. 80:617-653.
47. Zirakzadeh, A., and R. Patel. 2006. Vancomycin-resistant enterococci: colonization, infection, detection, and treatment. Mayo Clin. Proc. 81:529-536.