Black seed oil ameliorates allergic airway inflammation by inhibiting T-cell proliferation in rats

Pulmonary Pharmacology and Therapeutics

Volumn 22, Issue 1, 2009, Pages 37-43

  Shahzad, Muhammad ^a,b   Yang, Xudong ^a,b   Raza Asim, M B ^a,b   Sun, Qingzhu ^a,b   Han, Yan ^a,b   Zhang, Fujun ^a,b   Cao, Yongxiao ^a,b   Lu, Shemin ^a,b  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Black seed oil; Delayed type hypersensitivity; E3 rats; IgE; IgG; Nitric oxide; T cell proliferation

Indexed keywords

BLACK SEED OIL; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOMODULATING AGENT; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MESSENGER RNA; NITRIC OXIDE; OVALBUMIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CELL INFILTRATION; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNOMODULATION; INFLAMMATORY CELL; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN; T LYMPHOCYTE; TH2 CELL;

ANIMALS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION; INFLAMMATION; INFLAMMATION MEDIATORS; LUNG; MALE; MEDICINE, TRADITIONAL; NIGELLA; OVALBUMIN; PLANT OILS; RATS; RESPIRATORY HYPERSENSITIVITY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPLEEN; TH2 CELLS;

EID: 58349121886     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2008.11.006     Document Type: Article

References (43)

1. Walsh G.M. Novel therapies for asthma: advances and problems. Curr Pharm Des 11 (2005) 3027-3038
2. Abbas A.T., Abdel-Aziz M.M., Zalata K.R., and Abd Al-Galel Tel.-D. Effect of dexamethasone and Nigella sativa on peripheral blood eosinophil count, IgG1 and IgG2a, cytokine profiles and lung inflammation in murine model of allergic asthma. Egypt J Immunol 12 (2005) 95-102
3. Bielory L.B., and Lupoli K. Herbal intervention in asthma and allergy. J Asthma 36 (1999) 1-65
4. Markham A.W., and Wilkinson J.M. Complimentary and alternative medicines (CAM) in the management of asthma: an examination of the evidence. J Asthma 41 (2004) 131-139
5. Huntley A., and Ernst E. Herbal medicines for asthma: a systematic review. Thorax 55 (2000) 925-929
6. Ferdous A.J., Islam S.N., Ahsan M., Hasan C.M., and Ahmed Z.U. The in vitro antibacterial activity of the volatile oil of Nigella sativa seeds against multiple drug-resistant isolates of Shigella spp., Vibrio cholerae and Escherichia coli. Phytother Res 6 (1992) 137-140
7. Salomi M.J., Nair S.C., and Jayawardhanan K.K. Antitumor principles from Nigella sativa seeds. Cancer Lett 63 (1992) 41-46
8. Gilani A.H., Aziz N., Khurram I.M., Chaudhary K.S., and Iqbal A. Bronchodilator, spasmolytic and calcium antagonist activities of Nigella sativa seeds (Kalonji): a traditional herbal product with multiple medicinal uses. J Pak Med Assoc 51 (2001) 115-120
9. Salem M.L. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol 5 (2005) 1749-1770
10. Khan M. A translation of Al-Bukhari. Collection of Authentic Prophet (PBUH) saying. Division 71 (the book of medicine). 2nd ed. (1976), Hilal Yayinlari Publishers, Ankara (Turkey)
11. Atta-ur-Rahman, Malik, Cun-heng, and Clardy J. Isolation and structure determination of Nigellicine: a novel alkaloid from the seeds of Nigella sativa. Tetrahedron Lett 26 (1985) 2759-2762
12. Altan M.F., Kanter M., Donmez S., Kartal M.E., and Buyukbas S. Combination therapy of Nigella sativa and human parathyroid hormone on bone mass, biomechanical behavior and structure in streptozotocin-induced diabetic rats. Acta Histochem 109 (2007) 304-314
13. Tekeoglu I., Dogan A., Ediz L., Budancamanak M., and Demirel A. Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models. Phytother Res 21 (2007) 895-897
14. El Gazzar M., El Mezayen R., Marecki J.C., Nicolls M.R., Canastar A., and Dreskin S.C. Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. Int Immunopharmacol 6 (2006) 1135-1142
15. Kalus U., Pruss A., Bystron J., Jurecka M., Smekalova A., Lichius J.J., et al. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother Res 17 (2003) 1209-1214
16. Hawsawi Z.A., Ali B.A., and Bamosa A.O. Effect of Nigella sativa (black seed) and thymoquinone on blood glucose in albino rats. Ann Saudi Med 21 (2001) 242
17. Muir D., Varon S., and Manthorpe M. An enzyme-linked immunosorbent assay for bromodeoxyuridine incorporation using fixed microcultures. Anal Biochem 185 (1990) 377-382
18. Herrick C.A., and Bottomly K. To respond or not to respond: T cells in allergic asthma. Nat Rev Immunol 3 (2003) 405-412
19. Larche M., Robinson D.S., and Kay A.B. The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol 111 (2002) 450-463
20. Del Prete G.F., De Carli M., D'Elios M.M., Maestrelli P., Ricci M., Fabbri L., et al. Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders. Eur J Immunol 23 (1993) 1445-1449
21. Lucery D.R., Clerici M., and Shearer G.M. Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clin Microbiol Rev 9 (1996) 532-562
22. Cohn L., Tepper J.S., and Bottomly K. IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells. J Immunol 161 (1998) 3813-3816
23. Inoue H., Fukuyama S., Matsumoto K., Kubo M., and Yoshimura A. Role of endogenous inhibitors of cytokine signaling in allergic asthma. Curr Med Chem 14 (2007) 181-189
24. Hamid Q., Tulic M.K., Liu M.C., and Moqbel R. Inflammatory cells in asthma: mechanisms and implications for therapy. J Allergy Clin Immunol 111 (2003) S5-S12
25. Finkelman F., Katona I., Urban J., Holmes J., Ohara J., Tung A.S., et al. IL-4 is required to generate and sustain in vivo IgE response. J Immunol 141 (1988) 2335-2341
26. Emson C.L., Bell S.E., Jones A., Wisden W., and McKenzie A.N. Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13. J Exp Med 188 (1998) 399-404
27. Steinke J.W., and Borish L. Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists. Respir Res 2 (2001) 66-70
28. Roboz G.J., and Rafii S. Interleukin-5 and the regulation of eosinophil production. Curr Opin Hematol 6 (1999) 164-168
29. Doganci A., Sauer K., Karwot R., and Finotto S. Pathological role of IL-6 in the experimental allergic bronchial asthma in mice. Clin Rev Allergy Immunol 28 (2005) 257-270
30. Makinde T., Murphy R.F., and Agrawal D.K. The regulatory role of TGF-β in airway remodeling in asthma. Immunol Cell Biol 85 (2007) 348-356
31. Schafroth Török S., and Leuppi J.D. Bronchial hyper-responsiveness and exhaled nitric oxide in chronic obstructive pulmonary disease. Swiss Med Wkly 137 (2007) 385-391
32. Kanazawa H., Shoji S., Yoshikawa T., Hirata K., and Yoshikawa J. Increased production of endogenous nitric oxide in patients with bronchial asthma and chronic obstructive pulmonary disease. Clin Exp Allergy 28 (1998) 1244-1250
33. Corradi M., Pesci A., Casana R., Alinovi R., Goldoni M., Vettori M.V., et al. Nitrate in exhaled breath condensate of patients with different airway diseases. Nitric Oxide 8 (2003) 26-30
34. Lewandowicz A.M., and Pawliczak R. Arginine metabolism in bronchial asthma. Postepy Hig Med Dosw 61 (2007) 156-166
35. Hofstra C.L., Van Ark I., Hofman G., Nijkamp F.P., Jardieu P.M., and Van Oosterhout A.J. Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma. Am J Respir Cell Mol Biol 19 (1998) 826-835
36. O'Donnell C., and Liew E. Immunological aspects of nitric oxide. Biochemist 16 (1994) 19-22
37. Mahmood M.S., Gilani A.H., Khwaja A., Rashid A., and Ashfaq M.K. The in vitro effect of aqueous extract of Nigella sativa seeds on nitric oxide production. Phytother Res 17 (2003) 921-924
38. Jinquan T., Li W., Yuling H., and Lang C. All roads lead to Rome: pathways of NKT cells promoting asthma. Arch Immunol Ther Exp 54 (2006) 335-340
39. Wood L.J., Inman M.D., Denburg J.A., and O'Byrne P.M. Allergen challenge increases cell traffic between bone marrow and lung. Am J Respir Cell Mol Biol 18 (1998) 759-767
40. Li G., Liu Z., Ran P., Qiu J., and Zhong N. Activation of signal transducer and activator of transcription 5 (STAT5) in splenocyte proliferation of asthma mice induced by ovalbumin. Cell Mol Immunol 1 (2004) 471-474
41. Salim E.I., and Fukushima S. Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis. Nutr Cancer 45 (2003) 195-202
42. Salem M.L., and Hossain M.S. Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. Int J Immunopharmacol (2000) 22
43. Tsuyuki S., Tsuyuki J., Einsle K., Kopf M., and Coyle A.J. Co stimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness. J Exp Med 185 (1975) 1671-1679