Randomized, double-blind clinical trial to evaluate the efficacy of topical tacalcitol and sunlight exposure in the treatment of adult nonsegmental vitiligo

British Journal of Dermatology

Volumn 160, Issue 2, 2009, Pages 409-414

  Rodriguez Martin M ^a   Garcia Bustinduy M ^a   Saez Rodriguez M ^a   Noda Cabrera, A ^a  

^a HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

Author keywords

Clinical trial; Treatment; Vitamin D; Vitiligo

Indexed keywords

PLACEBO; TACALCITOL;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERANCE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHOTOTHERAPY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPAIN; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; VITILIGO;

ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; AGED; COMBINED MODALITY THERAPY; DERMATOLOGIC AGENTS; DIHYDROXYCHOLECALCIFEROLS; DOUBLE-BLIND METHOD; FEMALE; HELIOTHERAPY; HUMANS; MALE; MIDDLE AGED; OINTMENTS; SKIN PIGMENTATION; TREATMENT OUTCOME; VITILIGO;

EID: 58349121863     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2008.08906.x     Document Type: Article

References (25)

1. Kovacs SO. Vitiligo. J Am Acad Dermatol 1998 38 : 647 66.
2. Taïeb A, Picardo M. The definition and assessment of vitiligo: a consensus report of the Vitiligo European Task Force. Pigment Cell Res 2007 20 : 27 35.
3. Parsad D, Saini R, Verma N. Combination of PUVAsol and topical calcipotriol in vitiligo. Dermatology 1998 197 : 167 70.
4. Yalcim B, Salin S, Bukulmez G et al. Experience with calcipotriol as adjunctive treatment of vitiligo in patients who do not respond to PUVA alone. J Am Acad Dermatol 2001 44 : 634 7.
5. Hartmann A, Lurz C, Hamm H. Narrowband UVB 311 nm vs. broad band UVB therapy in combination with topical calcipotriol vs. placebo in vitiligo. Int J Dermatol 2005 44 : 736 42.
6. 3] and solar irradiation for vitiligo vulgaris: upregulation of c-Kit mRNA by cultured melanocytes. Eur J Dermatol 2003 13 : 372 6.
7. Vazquez López F, Lopez Escobar M, Perez Oliva N. Calcipotriene and vitiligo. Arch Dermatol 2003 139 : 1656 7.
8. Baysal V, Yildirim M, Erel A, Kesici D. Is the combination of calcipotriol and PUVA effective in vitiligo? J Eur Acad Dermatol Venereol 2003 17 : 299 302.
9. Dogra S, Parsad D. Combination of narrowband UVB and topical calcipotriene in vitiligo. Arch Dermatol 2003 139 : 393.
10. Lu-yan T, Wen-wen F, Lei-hong X et al. Topical tacalcitol and 308 nm monochromatic excimer light: a synergistic combination for the treatment of vitiligo. Photodermatol Photoimmunol Photomed 2006 22 : 310 14.
11. Leone G, Pacifico A, Iacovelli P et al. Tacalcitol and narrow band phototherapy in patients with vitiligo. Clin Exp Dermatol 2006 31 : 200 5.
12. Chiavérini C, Passeron T, Ortonne JP. Treatment of vitiligo by topical calcipotriol. J Eur Acad Dermatol Venereol 2002 16 : 137 8.
13. Glaser R, Rowert J, Mrowietz U. Hyperpigmentation due to topical calcipotriol and photochemotherapy in two psoriatic patients. Br J Dermatol 1998 139 : 148 51.
14. Rutter A, Schwarz T. Marked hyperpigmentation in psoriatic plaque as sequelae of combination therapy with UBV 311 and calcipotriol. Hautarzt 2000 51 : 431 3 in German R. What's new in the treatment of vitiligo? J Eur Acad Dermatol Venereol 2001 15 : 287 9.
15. Brown AJ. Vitamin D analogues. Am J Kidney Dis 1998 32 : 525 39.
16. Leone G, Pacifico A. Profile of clinical efficacy and safety of topical tacalcitol. Acta Biomed 2005 76 : 13 19.
17. Tomita Y, Miyamura Y, Kono M et al. Molecular bases of congenital hypopigmentary disorders in human and oculocutaneous albinismo 1 in Japan. Pigment Cell Res 2000 13 (Suppl. 8 130 4.
18. Amano H, Abe M, Ishikawa O. First case report of topical tacalcitol for vitiligo repigmentation. Pediatr Dermatol 2008 25 : 262 4.
19. Sitek JC, Loeb M, Ronnevig JR. Narrowband UVB therapy for vitiligo: does the repigmentation last? J Eur Acad Dermatol Venereol 2007 21 : 891 6.
20. Birlea SA, Costin GE, Norris DA. Cellular and molecular mechanism involved in the action of vitamin D analogs targeting vitiligo depigmentation. Curr Drug Targets 2008 9 : 345 59.
21. 3 on epidermal melanocytes. J Cell Physiol 1988 136 : 273 80.
22. Ameen H, Exarchou V, Chu AC. Topical calcipotriol as monotherapy and in combination with psoralen plus UVA in the treatment of vitiligo. Br J Dermatol 2001 145 : 476 9.
23. Ermics O, Alpsoy E, Cetin L, Yilmaz E. Is the efficacy of psoralen plus ultraviolet A therapy for vitiligo enhanced by topical calcipotriol? A placebo-controlled double blind study. Br J Dermatol 2001 145 : 472 5.
24. Kwok YKC, Anstey AV, Hawk JLM. Psoralen photochemotherapy (PUVA) is only moderately effective in widespread vitiligo: a 10 year retrospective study. Clin Exp Dermatol 2002 27 : 104 10.
25. Cui J, Shen LY, Wang GC. Role of hair follicles in the repigmentation of vitiligo. J Invest Dermatol 1991 97 : 410 16.