cDNA sequencing and expression of Nramp1 (Slc11a1) in dogs phenotypically resistant or susceptible to visceral leishmaniasis

Veterinary Immunology and Immunopathology

Volumn 127, Issue 3-4, 2009, Pages 332-339

  Bueno, Regina ^a   Carvalho Neta, Alcina V ^a   Xavier, Mariana N ^a   Oliveira, Raquel G ^a   Diniz, Soraia A ^b   Melo, Maria N ^a   Santos, Renato L ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b Setor de Vigilância Epidemiológica e Zoonoses   (Brazil)

Author keywords

Dog; Leishmania chagasi; Nramp1; Visceral leishmaniasis

Indexed keywords

COMPLEMENTARY DNA; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1; PROTEIN P35;

ANIMAL CELL; ARTICLE; CELL ISOLATION; COMPARATIVE STUDY; CONTROLLED STUDY; DNA SEQUENCE; DOG; INFECTION RESISTANCE; INFECTION SENSITIVITY; LEISHMANIA CHAGASI; MACROPHAGE; MONOCYTE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN EXPRESSION; SPLEEN; VISCERAL LEISHMANIASIS;

ANIMALS; BASE SEQUENCE; CATION TRANSPORT PROTEINS; DNA, COMPLEMENTARY; DOG DISEASES; DOGS; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; LEISHMANIASIS, VISCERAL; MACROPHAGES;

CANIS FAMILIARIS; LEISHMANIA DONOVANI CHAGASI; MUS;

EID: 58349119169     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2008.10.335     Document Type: Article

References (43)

1. Adams L.G., and Templeton J.W. Genetic resistance to bacterial diseases of animals. Rev. Sci. Tech. Off. Int. Epizoot. 17 (1998) 200-219
2. Altet L., Francino O., Solano-Gallego L., Renier C., and Sánchez A. Mapping and sequencing of canine NRAMP1 gene and identification of mutations in leishmaniasis-susceptible dogs. Infect. Immun. 70 (2002) 2763-2771
3. Ashford D.A., David J.R., Freire M., David R., Sherlock I., Eulálio M.C., Sampaio D.P., and Badaro R. Studies on control of visceral leishmaniasis: impact of dog control on canine and human visceral leishmaniasis in Jacobina, Bahia, Brazil. Am. J. Trop. Med. Hyg. 59 (1998) 53-57
4. Bellamy R., Ruwende C., Corrah T., McAdam K.P., Whittle H.C., and Hill A.V. Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans. N. Engl. J. Med. 338 (1998) 640-644
5. Blackwell J.M. Regulation of Leishmania populations within the host. V. Resistance to L. donovani in wild mice. J. Trop. Med. Hyg. 86 (1983) 17-22
6. Blackwell J.M. Genetic susceptibility to leishmanial infections: studies in mice and man. Parasitology 112 (1996) S67-74
7. Blackwell J.M. Genetics of host resistance and susceptibility to intramacrophage pathogens: a study of multicase families of tuberculosis, leprosy and leishmaniasis in north-eastern Brazil. Int. J. Parasitol. 28 (1998) 21-28
8. Blackwell J.M., and Searle S. Genetic regulation of macrophage activation: understanding the function of Nramp1 (=Ity/Lsh/Bcg). Immunol. Lett. 65 (1999) 73-80
9. Blackwell J.M., Searle S., Mohamed H., and White J.K. Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story. Rev. Immunol. Lett. 85 (2003) 197-203
10. Bradley D.J. Regulation of Leishmania populations within the host. II. Genetic control of acute susceptibility of mice to Leishmania donovani infection. Clin. Exp. Immunol. 30 (1977) 130-140
11. Bradley D.J., Taylor B.A., Blackwell J., Evans E.P., and Freeman J. Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse. Clin. Exp. Immunol. 37 (1979) 7-14
12. Bucheton B., Abel L., Kheir M.M., Mirgani A., El-Safi S.H., Chevillard C., and Dessein A. Genetic control of visceral leishmaniosis in a Sudanese population: candidate gene testing indicates a linkage to the NRAMP1 region. Genes Immun. 4 (2003) 104-109
13. Bueno R., Mello M.N., Menezes C.A.S., Dutra W.O., and Santos R.L. Phenotypic, functional, and quantitative characterization of canine peripheral blood monocyte-derived macrophages. Mem. Inst. Oswaldo Cruz 100 (2005) 521-524
14. Campbell G.A., and Adams L.G. The long-term culture of bovine monocyte-derived macrophages and their use in the study of intracellular proliferation of Brucella abortus. Vet. Immunol. Immunopathol. 34 (1992) 291-305
15. Canonne-Hergaux F., Gruenheid S., Govoni G., and Gros P. The Nramp1 protein and its role in resistance to infection and macrophage function. Proc. Assoc. Am. Physicians 111 (1999) 283-289
16. Crocker P.R., Blackwell J.M., and Bradley D.J. Transfer of innate resistance and susceptibility to Leishmania donovani infection in mouse radiation bone marrow chimaeras. Immunology 52 (1984) 417-422
17. Diniz S.A., Silva F.L., Carvalho Neta A.V., Bueno R., Guerra R.M.N.S.C., Abreu Silva A.L., and Santos R.L. Animal reservoirs for visceral leishmaniasis in densely populated urban areas. J. Infect. Developing Countries 2 (2008) 24-33
18. Forbes J.R., and Gros P. Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions. Rev. Trends Microbiol. 9 (2001) 397-403
19. Grimaldi Jr. G., and Tesh R.B. Leishmaniases of the New World: current concepts and implications for the future research. Clin. Microbiol. Rev. 6 (1993) 230-250
20. Gros P., Skamene E., and Forget A. Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice. J. Immunol. 127 (1981) 2417-2421
21. Gros P., Skamene E., and Forget A. Cellular mechanisms of genetically controlled host resistance to Mycobacterium bovis (BCG). J. Immunol. 131 (1983) 1966-1972
22. Gruenheid S., Pinner E., Desjardins M., and Gros P. Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. J. Exp. Med. 185 (1997) 717-730
23. Lissner C.R., Swanson R.N., and O'Brien A.D. Genetic control of the innate resistance of mice to Salmonella typhimurium: expression of the Ity gene in peritoneal and splenic macrophages isolated in vitro. J. Immunol. 131 (1983) 3006-3013
24. -ΔΔCT Method. Methods 25 (2001) 402-408
25. Madeira M., Barbosa-Santos E., and Marzochi M. Experimental infection of canine peritoneal macrophages with visceral and dermotropic Leishmania strains. Mem. Inst. Oswaldo Cruz 94 (1999) 645-648
26. Mohamed H.S., Muntaser E.I., Miller E.N., White J.K., Cordell H.J., Howson J.M., Peacock C.S., Khalil E.A., El Hassan A.M., and Blackwell J.M. SLC11A1 (formerly Nramp1) and susceptibility to visceral leishmaniasis in the Sudan. Eur. J. Hum. Genet. 12 (2004) 66-74
27. Olivier M., and Tanner C.E. Susceptibilities of macrophage populations to infection in vitro by Leishmania donovani. Infect. Immun. 55 (1987) 467-471
28. Paixão T.A., Ferreira C., Borges A.M., Oliveira D.A.A., Lage A.P., and Santos R.L. Frequency of bovine Nramp1 (Slc11a1) alleles in Holstein and Zebu breeds. Vet. Immunol. Immunopathol. 109 (2006) 37-42
29. Paixão T.A., Poester F.P., Carvalho Neta A.V., Borges A.M., Lage A.P., and Santos R.L. NRAMP1 3′UTR polymorphisms are not associated with natural resistance to Brucella abortus in cattle. Infect. Immun. 75 (2007) 2493-2499
30. Price R.E., Templeton J.W., Smith III R., and Adams L.G. Ability of mononuclear phagocytes from cattle naturally resistant or susceptible to brucellosis to control in vitro intracellular survival of Brucella abortus. Infect. Immun. 58 (1990) 879-886
31. Quinnell R.J., Kennedy L.J., Barnes A., Courtenay O., Dye C., Garcez L.M., Shaw M.A., Carter S.D., Thomson W., and Ollier W.E. Susceptibility to visceral leishmaniasis in the domestic dog is associated with MHC class II polymorphism. Immunogenetics 55 (2003) 23-28
32. Qureshi T., Templeton J.W., and Adams L.G. Intracellular survival of Brucella abortus, Mycobacterium bovis BCG, Salmonella dublin, and Salmonella typhimurium in macrophages from cattle genetically resistant to Brucella abortus. Vet. Immunol. Immunopathol. 50 (1996) 55-65
33. Rodriguez N.E., Chang H.K., and Wilson M.E. Novel program of macrophage gene expression induced by phagocytosis of Leishmania chagasi. Infect. Immun. 72 (2004) 2111-2122
34. Sanchez-Robert E., Altet L., Sanchez A., and Francino O. Polymorphism of Slc11A1 (Nramp1) gene and canine leishmaniasis in a case-control study. J. Hered. 96 (2005) 755-758
35. Sanchez-Robert E., Altet L., Utzet-Sadurni M., Giger U., Sanchez A., and Francino O. Slc11a1 (formerly Nramp1) and susceptibility to canine visceral leishmaniasis. Vet. Res. 39 (2008) 36
36. Searle S., and Blackwell J.M. Evidence for a functional repeat polymorphism in the promoter of the human NRAMP1 gene that correlates with autoimmune versus infectious disease susceptibility. J. Med. Genet. 36 (1999) 295-299
37. Shaw M.A., Collins A., Peacock C.S., Miller E.N., Black G.F., Sibthorpe D., Lins-Lainson Z., Shaw J.J., Ramos F., Silveira F., and Blackwell J.M. Evidence that genetic susceptibility to Mycobacterium tuberculosis in a Brazilian population is under oligogenic control: linkage study of the candidate genes NRAMP1 and TNFA. Tuber. Lung Dis. 78 (1997) 35-45
38. Stach J.L., Delgado G., Tchibozo V., Strobel M., and Lagrange P.H. Natural resistance to mycobacteria: antimicrobial activity and reactive oxygen intermediate releasing functions of murine macrophages. Ann. Immunol. 135D (1984) 25-37
39. Tuite A., and Gros P. The impact of genomics on the analysis of host resistance to infectious disease. Microbes Infect. 8 (2006) 1647-1653
40. Vidal S.M., Malo D., Vogan K., Skamene E., and Gros P. Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell 73 (1993) 469-485
41. Vidal S.M., Tremblay M.L., Govoni G., Gauthier S., Sebastiani G., Malo D., Skamene E., Olivier M., Jothy S., and Gros P. The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J. Exp. Med. 182 (1995) 655-666
42. Wardley R.C., Lawman M.J., and Hamilton F. The establishment of continuous macrophage cell lines from peripheral blood monocytes. Immunology 39 (1980) 67-73
43. Zaahl M.G., Robson K.J., Warnich L., and Kotze M.J. Expression of the SLC11A1 (NRAMP1) 5′-(GT)n repeat: opposite effect in the presence of -237C-T. Blood Cells Mol. Dis. 33 (2004) 45-50