All trans-retinoic acid induces apoptosis via p38 and caspase pathways in metaplastic Barrett's cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 292, Issue 1, 2007, Pages

  Hormi Carver, Kathy ^a   Feagins, Linda A ^a   Spechler, Stuart J ^a   Souza, Rhonda F ^a,b,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

Author keywords

Barrett's esophagus; Caspase cascade; p53; Retinoids

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P53; RETINOIC ACID; SMALL INTERFERING RNA; TELOMERASE;

APOPTOSIS; ARTICLE; BARRETT ESOPHAGUS; CELL LINE; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; METAPLASIA; NICK END LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; STAINING; ULTRAVIOLET B RADIATION;

APOPTOSIS; BARRETT ESOPHAGUS; CASPASES; CELL CULTURE TECHNIQUES; CELL LINE; FLOW CYTOMETRY; HUMANS; METAPLASIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RNA INTERFERENCE; TRETINOIN; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 33846166714     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00237.2006     Document Type: Article

References (26)

1. Alsayed Y, Uddin S, Mahmud N, Lekmine F, Kalvakolanu DV, Minucci S, Bokoch G, Platanias LC. Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to all-trans-retinoic acid. J Biol Chem 276: 4012-4019, 2001.
2. Altucci L, Gronemeyer H. The promise of retinoids to fight against cancer. Nat Rev Cancer 1: 181-193, 2001.
3. Assefa Z, Vantieghem A, Garmyn M, Declercq W, Vandenabeele P, Vandenheede JR, Bouillon R, Merlevede W, Agostinis P. p38 mitogen-activated protein kinase regulates a novel, caspase-independent pathway for the mitochondrial cytochrome c release in ultraviolet B radiation-induced apoptosis. J Biol Chem 275: 21416-21421, 2000.
4. Baltes S, Nau H, Lampen A. All-trans retinoic acid enhances differentiation and influences permeability of intestinal Caco-2 cells under serum-free conditions. Dev Growth Differ 46: 503-514, 2004.
5. Bartolini G, Ammar K, Mantovani B, Scanabissi F, Ferreri AM, Rocchi P, Orlandi M. Retinoids and cancer: antitumor effect of ATRA and of a new derivative of retinoic acid, IIF, on colon carcinoma cell lines CaCo-2 and HT-29. Anticancer Res 24: 1779-1783, 2004.
6. Chen H, Tucker KL, Graubard BI, Heineman EF, Markin RS, Potischman NA, Russell RM, Weisenburger DD, Ward MH. Nutrient intakes and adenocarcinoma of the esophagus and distal stomach. Nutr Cancer 42: 33-40, 2002.
7. Cotton J, Spandau DF. Ultraviolet B-radiation dose influences the induction of apoptosis and p53 in human keratinocytes. Radiat Res 147: 148-155, 1997.
8. Fennerty B, Sampliner R, Garewal H. Esophageal ulceration associated with 13-cis-retinoic acid therapy in patients with Barrett's esophagus. Gastrointest Endosc 35: 442-443, 1989.
9. Holmes WF, Soprano DR, Soprano KJ. Elucidation of molecular events mediating induction of apoptosis by synthetic retinoids using a CD437-resistant ovarian carcinoma cell line. J Biol Chem 277: 45408-45419, 2002.
10. Jaiswal K, Lopez-Guzman C, Souza RF, Spechler SJ, Sarosi GA Jr. Bile salt exposure increases proliferation through p38 and ERK MAPK pathways in a non-neoplastic Barrett's cell line. Am J Physiol Gastrointest Liver Physiol 290: G335-G342, 2006.
11. MacFarlane M, Cohen GM, Dickens M. JNK (c-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: differential requirements for caspase activation. Biochem J 348: 93-101, 2000.
12. Mayne ST, Risch HA, Dubrow R, Chow WH, Gammon MD, Vaughan TL, Farrow DC, Schoenberg JB, Stanford JL, Ahsan H, West AB, Rotterdam H, Blot WJ, Fraumeni JF Jr. Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev 10: 1055-1062, 2001.
13. McCormack SA, Viar MJ, Tague L, Johnson LR. Altered distribution of the nuclear receptor RAR beta accompanies proliferation and differentiation changes caused by retinoic acid in Caco-2 cells. In Vitro Cell Dev Biol Anim 32: 53-61, 1996.
14. Morales CP, Ramirez NG, Gandia KG, Ramirez RD, Shaw JW, Spechler SJ. Ectopic telomerase for the generation of cell lines from Barrett's esophagus (Abstract). Gastroenterology 122: A-57, 2002.
15. Mrass P, Rendl M, Mildner M, Gruber F, Lengauer B, Ballaun C, Eckhart L, Tschachler E. Retinoic acid increases the expression of p53 and proapoptotic caspases and sensitizes keratinocytes to apoptosis: a possible explanation for tumor preventive action of retinoids. Cancer Res 64: 6542-6548, 2004.
16. Pasquali D, Bellastella A, Colantuoni V, Vassallo P, Bonavolonta G, Rossi V, Notaro A, Sinisi AA. All-trans retinoic acid- and N-(4-hydroxyphenil)-retinamide-induced growth arrest and apoptosis in orbital fibroblasts in Graves' disease. Metabolism 52: 1387-1392, 2003.
17. Pfahl M, Piedrafita FJ. Retinoid targets for apoptosis induction. Oncogene 22: 9058-9062, 2003.
18. Pohl H, Welch HG. The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidence. J Natl Cancer Inst 97: 142-146, 2005.
19. Rendl M, Ban J, Mrass P, Mayer C, Lengauer B, Eckhart L, Declerq W, Tschachler E. Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner. J Invest Dermatol 119: 1150-1155, 2002.
20. Shaheen NJ, Crosby MA, Bozymski EM, Sandler RS. Is there publication bias in the reporting of cancer risk in Barrett's esophagus? Gastroenterology 119: 333-338, 2000.
21. Smith W, Saba N. Retinoids as chemoprevention for head and neck cancer: where do we go from here? Crit Rev Oncol Hematol 55: 143-152, 2005.
22. Souza RF, Shewmake K, Terada LS, Spechler SJ. Acid exposure activates the mitogen-activated protein kinase pathways in Barrett's esophagus. Gastroenterology 122: 299-307, 2002.
23. Sun SY, Yue P, Wu GS, El Deiry WS, Shroot B, Hong WK, Lotan R. Implication of p53 in growth arrest and apoptosis induced by the synthetic retinoid CD437 in human lung cancer cells. Cancer Res 59: 2829-2833, 1999.
24. Sun SY, Yue P, Wu GS, El Deiry WS, Shroot B, Hong WK, Lotan R. Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells. Oncogene 18: 2357-2365, 1999.
25. Vaishampayan U, Heilbrun LK, Parchment RE, Jain V, Zwiebel J, Boinpally RR, LoRusso P, Hussain M. Phase II trial of fenretinide in advanced renal carcinoma. Invest New Drugs 23: 179-185, 2005.
26. Zhuang S, Demirs JT, Kochevar IE. p38 mitogen-activated protein kinase mediates bid cleavage, mitochondrial dysfunction, and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen peroxide. J Biol Chem 275: 25939-25948, 2000.