Reducing the Cyclic Variations of Ultrasonic Integrated Backscatters and Myocardial Electrical Synchronism by Reversibly Blocking Intercellular Communications with Heptanol

Ultrasound in Medicine and Biology

Volumn 35, Issue 2, 2009, Pages 209-218

  Lin, Lung Chun ^a   Wu, Chau Chung ^a   Lin, Mao Shin ^a   Lin, Shien Fong ^b   Liu, Yen Bin ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Connexin; Heptanol; Optical mapping; Strain rate imaging; Ultrasonic integrated backscatters

Indexed keywords

CONNEXIN; HEPTANOL; OPTICAL MAPPING; STRAIN RATE IMAGING; ULTRASONIC INTEGRATED BACKSCATTERS;

BACKSCATTERING; BIOCHEMISTRY; CONFORMAL MAPPING; FUNCTIONS; GALLIUM ALLOYS; PROBABILITY DENSITY FUNCTION; ULTRASONIC IMAGING; ULTRASONICS;

STRAIN RATE;

HEPTANOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COMMUNICATION; ECHOGRAPHY; GAP JUNCTION; HEART CONDUCTION; HEART CYCLE; HEART ELECTROPHYSIOLOGY; HEART FUNCTION; HEART MUSCLE CONTRACTILITY; HEART REPOLARIZATION; MUSCLE ACTION POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RABBIT; SYSTOLIC BLOOD PRESSURE;

ACTION POTENTIALS; ANIMALS; ECHOCARDIOGRAPHY, DOPPLER; GAP JUNCTIONS; HEART CONDUCTION SYSTEM; HEPTANOL; MICROSCOPY, FLUORESCENCE; MODELS, ANIMAL; MYOCARDIAL CONTRACTION; PERFUSION; RABBITS; SCATTERING, RADIATION;

EID: 58249128060     PISSN: 03015629     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2008.08.019     Document Type: Article

References (32)

1. Bastide B., Herve J.C., Cronier L., and Deleze J. Rapid onset and calcium independence of the gap junction uncoupling induced by heptanol in cultured heart cells. Pflugers Arch 429 (1995) 386-393
2. Christ G.J., Spektor M., Brink P.R., and Barr L. Further evidence for the selective disruption of intercellular communication by heptanol. Am J Physiol 276 (1999) H1911-H1917
3. Danik S.B., Liu F., Zhang J., Suk H.J., Morley G.E., Fishman G.I., and Gutstein D.E. Modulation of cardiac gap junction expression and arrhythmic susceptibility. Circ Res 95 (2004) 1035-1041
4. Dhein S., Krüsemann K., and Schaefer T. Effects of the gap junction uncoupler palmitoleic acid on the activation and repolarization wavefronts in isolated rabbit hearts. Br J Pharmacol 128 (1999) 1375-1384
5. Dhein S. Cardiac ischemia and uncoupling: gap junctions in ischemia and infarction. Adv Cardiol 42 (2006) 198-212
6. Di Bello V., Giorgi D., Talini E., Dell' Omo G., Palagi C., Romano M.F., Pedrinelli R., and Mariani M. Incremental value of ultrasonic tissue characterization (backscatter) in the evaluation of left ventricular myocardial structure and mechanics in essential arterial hypertension. Circulation 107 (2003) 74-80
7. Dupont E., Matsushita T., Kaba R.A., Vozzi C., Coppen S.R., Khan N., Kaprielian R., Yacoub M.H., and Severs N.J. Altered connexin expression in human congestive heart failure. J Mol Cell Cardiol 33 (2001) 359-371
8. Efimov I.R. Connections, connections, connexins: Towards systems biology paradigm of cardiac arrhythmia. J Mol Cell Cardiol 41 (2006) 949-951
9. Efimov I.R., Nikolski V.P., and Salama G. Optical imaging of the heart. Circ Res 95 (2004) 21-33
10. Gutstein D.E., Morley G.E., Tamaddon H., Vaidya D., Schneider M.D., Chen J., Chien K.R., Stuhlmann H., and Fishman G.I. Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res 88 (2001) 333-339
11. Gysembergh A., Kloner R.A., and Przyklenk K. Pretreatment with the gap junction uncoupler heptanol does not limit infarct size in rabbit heart. Cardiovasc Pathol 10 (2001) 13-17
12. Kaprielian R.R., Gunning M., Dupont E., Sheppard M.N., Rothery S.M., Underwood R., Pennell D.J., Fox K., Pepper J., Poole-Wilson P.A., and Severs N.J. Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle. Circulation 97 (1998) 651-660
13. Keevil V.L., Huang C.L., Chau P.L., Sayeed R.A., and Vandenberg J.I. The effect of heptanol on the electrical and contractile function of the isolated, perfused rabbit heart. Pflugers Arch 440 (2000) 275-282
14. 2+ fluctuation in cultured neonatal rat cardiac myocytes by heptanol. Exp Cell Res 220 (1995) 348-356
15. Kjølbye A.L., Holstein-Rathlou N.H., and Petersen J.S. Anti-arrhythmic peptide N-3-(4-hydroxyphenyl)propionyl Pro-Hyp-Gly-Ala-Gly-OH reduces dispersion of action potential duration during ischemia/reperfusion in rabbit hearts. J Cardiovasc Pharmacol 40 (2002) 770-779
16. Lerner D.L., Beardslee M.A., and Saffitz J.E. The role of altered intercellular coupling in arrhythmias induced by acute myocardial ischemia. Cardiovasc Res 50 (2001) 263-269
17. Lin L.C., Kao H.L., Wu C.C., Ho Y.L., and Lee Y.T. Alterations of myocardial ultrasonic tissue characterization by coronary angioplasty in patients with chronic stable coronary artery disease. Ultrasound Med Biol 27 (2001) 1191-1198
18. Lin L.C., Wu C.C., Yeh H.I., Lu L.S., Liu Y.B., Lin S.F., and Lee Y.T. Downregulated myocardial connexin 43 and suppressed contractility in rabbits subjected to a cholesterol-enriched diet. Lab Invest 85 (2005) 1224-1237
19. Lin L.C., Yen R.F., Hwang J.J., Chiang F.T., Tseng C.D., and Huang P.J. Ultrasonic tissue characterization evaluates myocardial viability and ischemia in patients with coronary artery disease. Ultrasound Med Biol 26 (2000) 759-769
20. Liu Y.B., Wu C.C., Lu L.S., Su M.J., Lin C.W., Lin S.F., Chen L.S., Fishbein M.C., Chen P.S., and Lee Y.T. Sympathetic nerve sprouting, electrical remodeling, and increased vulnerability to ventricular fibrillation in hypercholesterolemic rabbits. Circ Res 92 (2003) 1145-1152
21. Liu Y.-B., Peter A., Lamp S.T., Weiss J.N., Chen P.-S., and Lin S.-F. Spatiotemporal correlation between phase singularities and wavebreaks during ventricular fibrillation. J Cardiovasc Electrophysiol 14 10 (2003) 1103-1109
22. Marwick T.H. Measurement of strain and strain rate by echocardiography: Ready for prime time?. J Am Coll Cardiol 47 (2006) 1313-1327
23. Nelson W.L., and Makielski J.C. Block of sodium current by heptanol in voltage-clamped canine cardiac Purkinje cells. Circ Res 68 (1991) 977-983
24. Niggli E., Rudisuli A., Maurer P., and Weingart R. Effects of general anesthetics on current flow across membranes in guinea pig myocytes. Am J Physiol 256 (1989) C273-C281
25. Oyamada M., Kimura H., Oyamada Y., Miyamoto A., Ohshika H., and Mori M. The expression, phosphorylation, and localization of connexin 43 and gap-junctional intercellular communication during the establishment of a synchronized contraction of cultured neonatal rat cardiac myocytes. Exp Cell Res 212 (1994) 351-358
26. Pak H.N., Oh Y.S., Liu Y.B., Wu T.J., Karagueuzian H.S., Lin S.F., and Chen P.S. Catheter ablation of ventricular fibrillation in rabbit ventricles treated with beta-blockers. Circulation 108 (2003) 3149-3156
27. Peters N.S., Green C.R., Poole-Wilson P.A., and Severs N.J. Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts. Circulation 88 (1993) 864-875
28. Roell W., Lewalter T., Sasse P., Tallini Y.N., Choi B.R., Breitbach M., Doran R., Becher U.M., Hwang S.M., Bostani T., von Maltzahn J., Hofmann A., Reining S., Eiberger B., Gabris B., Pfeifer A., Welz A., Willecke K., Salama G., Schrickel J.W., Kotlikoff M.I., and Fleischmann B.K. Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia. Nature 450 (2007) 819-824
29. Rose J.H., Kaufmann M.R., Wickline S.A., Hall C.S., and Miller J.G. A proposed microscopic elastic wave theory for ultrasonic backscatter from myocardial tissue. J Acoust Soc Am 97 (1995) 656-668
30. Severs N.J., Coppen S.R., Dupont E., Yeh H.I., Ko Y.S., and Matsushita T. Gap junction alterations in human cardiac disease. Cardiovasc Res 62 (2004) 368-377
31. Takens-Kwak B.R., Jongsma H.J., Rook M.B., and Van Ginneken A.C. Mechanism of heptanol-induced uncoupling of cardiac gap junctions: A perforated patch-clamp study. Am J Physiol 262 (1992) C1531-C1538
32. van Veen T.A.B., van Rijen H.V.M., and Opthof T. Cardiac gap junction channels: Modulation of expression and channel properties. Cardiovasc Res 51 (2001) 217-229