Pretreatment with the gap junction uncoupler heptanol does not limit infarct size in rabbit heart

Cardiovascular Pathology

Volumn 10, Issue 1, 2001, Pages 13-17

  Gysembergh, Anne ^a   Kloner, Robert A ^a   Przyklenk, Karin ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Calcium; Gap junctions; Myocardial ischemia; Myocordial infarction

Indexed keywords

HEPTANOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COMMUNICATION; CELL JUNCTION; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY OBSTRUCTION; HEART INDEX; HEART INFARCTION SIZE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE NECROSIS; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALS; CORONARY CIRCULATION; GAP JUNCTIONS; HEART; HEMODYNAMIC PROCESSES; HEPTANOL; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; NECROSIS; PERFUSION; RABBITS; UNCOUPLING AGENTS; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0035792997     PISSN: 10548807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1054-8807(00)00056-9     Document Type: Article

References (17)

1. Distribution and three-dimensional structure of intercellular junctions in canine myocardium
2. Effects of the gap junction uncoupler palmitoleic acid on the activation and repolarization wavefronts in isolated rabbit hearts
3. Heptanol-induced decrease in cardiac gap junctional conductance is mediated by a decrease in the fluidity of membranous cholesterol-rich domains
4. Gap junction uncoupler heptanol prevents cell-to-cell progression of hypercontracture and limits necrosis during myocardial reperfusion
5. 3 signaling mimics preconditioning in rabbit heart
6. p38 mitogen-activated protein kinase activity is not increased in preconditioned versus control rabbit heart
7. What is the required reperfusion period for the assessment of myocardial infarct size using triphenyltetrazolium staining?
8. Acute ethanol does not protect against ischemia/reperfusion injury in rabbit myocardium
9. Acute ethanol exposure does not limit infarct size in in situ rabbit hearts
10. Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke
11. Gap junction-mediated propagation and amplification of cell injury
12. Astrocytic gap junctions remain open during ischemic conditions
13. 2+, intercellular electrical coupling, and mechanical activity in ischemic rabbit papillary muscles
14. Intercellular propagation of calcium waves mediated by inositol trisphosphate
15. Cellular mechanisms of infarct size reduction with preconditioning: role of calcium?
16. Mechanism of heptanol-induced uncoupling of cardiac gap junctions: a perforated patch-clamp study
17. Further evidence for the selective disruption of intercellular communication by heptanol