Activation of synoviolin promoter in rheumatoid synovial cells by a novel transcription complex of interleukin enhancer binding factor 3 and GA binding protein α

Arthritis and Rheumatism

Volumn 60, Issue 1, 2009, Pages 63-72

  Izumi, Toshihiko ^a,b   Fujii, Ryoji ^a   Izumi, Tomonori ^c   Nakazawa, Minako ^a   Yagishita, Naoko ^a   Tsuchimochi, Kaneyuki ^b   Yamano, Yoshihisa ^a   Sato, Tomoo ^a   Fujita, Hidetoshi ^a   Aratani, Satoko ^a   Araya, Natsumi ^a   Azakami, Kazuko ^a   Hasegawa, Daisuke ^a   Kasaoka, Shunji ^c   Tsuruta, Ryosuke ^d   Yokouti, Masahiro ^b   Ijiri, Kosei ^b   Beppu, Moroe ^a   Maruyama, Ikuro ^b   Nishioka, Kusuki ^a   Maekawa, Tsuyoshi ^c   Komiya, Setsuro ^b   Nakajima, Toshihiro ^a,e,f   more..

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d YAMAGUCHI UNIVERSITY HOSPITAL   (Japan)

^e Fukushimura Hospital   (Japan)

^f Misato Marine Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GA BINDING PROTEIN; INTERLEUKIN 2; INTERLEUKIN ENHANCER BINDING FACTOR 3; SYNOVIOLIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTHRITIS; ARTICLE; BINDING SITE; DNA SEQUENCE; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; LIQUID CHROMATOGRAPHY; OSTEOARTHRITIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN PURIFICATION; RHEUMATOID ARTHRITIS; RNA INTERFERENCE; SYNOVIOCYTE; SYNOVIUM; TANDEM MASS SPECTROMETRY;

ANIMALS; ARTHRITIS, RHEUMATOID; GA-BINDING PROTEIN TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; JURKAT CELLS; MICE; NIH 3T3 CELLS; NUCLEAR FACTOR 90 PROTEINS; NUCLEAR PROTEINS; OSTEOARTHRITIS; PROMOTER REGIONS, GENETIC; RNA INTERFERENCE; SYNOVIAL MEMBRANE; UBIQUITIN-PROTEIN LIGASES;

EID: 58249113837     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24178     Document Type: Article

References (45)

1. Amano T, Yamasaki S, Yagishita N, Tsuchimochi K, Shin H, Kawahara K, et al. Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev 2003;17:2436-49.
2. Yamasaki S, Yagishita N, Tsuchimochi K, Nishioka K, Nakajima T. Rheumatoid arthritis as a hyper-endoplasmic-reticulum-associated degradation disease. Arthritis Res Ther 2005;7:181-6.
3. Hampton RY. ER-associated degradation in protein quality control and cellular regulation. Curr Opin Cell Biol 2002;14:476-82.
4. Toh ML, Marotte H, Blond JL, Jhumka U, Eljaafari A, Mougin B, et al. Overexpression of synoviolin in peripheral blood and synoviocytes from rheumatoid arthritis patients and continued elevation in nonresponders to infliximab treatment. Arthritis Rheum 2006;54:2109-18.
5. Yagishita N, Ohneda K, Amano T, Yamasaki S, Sugiura A, Tsuchimochi K, et al. Essential role of synoviolin in embryogenesis. J Biol Chem 2005;280:7909-16.
6. Tsuchimochi K, Yagishita N, Yamasaki S, Amano T, Kato Y, Kawahara K, et al. Identification of a crucial site for synoviolin expression. Mol Cell Biol 2005;25:7344-56.
7. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
8. Goto M, Sasano M, Yamanaka H, Miyasaka N, Kamatani N, Inoue K, et al. Spontaneous production of an interleukin 1-like factor by cloned rheumatoid synovial cells in long-term culture. J Clin Invest 1987;80:786-96.
9. Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 1983;11:1475-89.
10. Natsume T, Yamauchi Y, Nakayama H, Shinkawa T, Yanagida M, Takahashi N, et al. A direct nanoflow liquid chromatography-tandem mass spectrometry system for interaction proteomics. Anal Chem 2002;74:4725-33.
11. Yamasaki S, Yagishita N, Sasaki T, Nakazawa M, Kato Y, Yamadera T, et al. Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J 2007;26:113-22.
12. Zimmermann T, Kunisch E, Pfeiffer R, Hirth A, Stahl HD, Sack U, et al. Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture - primary culture cells markedly differ from fourth-passage cells. Arthritis Res 2001;3:72-6.
13. Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, et al. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. J Biol Chem 1994;269:20691-9.
14. Reichman TW, Muniz LC, Mathews MB. The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells. Mol Cell Biol 2002;22:343-56.
15. Reichman TW, Parrott AM, Fierro-Monti I, Caron DJ, Kao PN, Lee CG, et al. Selective regulation of gene expression by nuclear factor 110, a member of the NF90 family of double-stranded RNA-binding proteins. J Mol Biol 2003;332:85-98.
16. Ranpura SA, Deshmukh U, Reddi PP. NF45 and NF90 in murine seminiferous epithelium: potential role in SP-10 gene transcription. J Androl 2008;29:186-97.
17. Reichman TW, Mathews MB. RNA binding and intramolecular interactions modulate the regulation of gene expression by nuclear factor 110. RNA 2003;9:543-54.
18. Corthesy B, Kao PN. Purification by DNA affinity chromatography of two polypeptides that contact the NF-AT DNA binding site in the interleukin 2 promoter. J Biol Chem 1994;269:20682-90.
19. Saunders LR, Perkins DJ, Balachandran S, Michaels R, Ford R, Mayeda A, et al. Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR. J Biol Chem 2001;276:32300-12.
20. Parker LM, Fierro-Monti I, Mathews MB. Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase. J Biol Chem 2001;276:32522-30.
21. Xu YH, Busald C, Grabowski GA. Reconstitution of TCP80/NF90 translation inhibition activity in insect cells. Mol Genet Metab 2000;70:106-15.
22. Shim J, Lim H, Yates JR, Karin M. Nuclear export of NF90 is required for interleukin-2 mRNA stabilization. Mol Cell 2002;10:1331-44.
23. Larcher JC, Gasmi L, Viranaicken W, Edde B, Bernard R, Ginzburg I, et al. Ilf3 and NF90 associate with the axonal targeting element of Tau mRNA. FASEB J 2004;18:1761-3.
24. Nie Y, Ding L, Kao PN, Braun R, Yang JH. ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing. Mol Cell Biol 2005;25:6956-63.
25. Parrott AM, Walsh MR, Reichman TW, Mathews MB. RNA binding and phosphorylation determine the intracellular distribution of nuclear factors 90 and 110. J Mol Biol 2005;348:281-93.
26. Shi L, Zhao G, Qiu D, Godfrey WR, Vogel H, Rando TA, et al. NF90 regulates cell cycle exit and terminal myogenic differentiation by direct binding to the 3′-untranslated region of MyoD and p21WAF1/CIP1 mRNAs. J Biol Chem 2005;280:18981-9.
27. Pei Y, Zhu P, Dang Y, Wu J, Yang X, Wan B, et al. Nuclear export of NF90 to stabilize IL-2 mRNA is mediated by AKT-dependent phosphorylation at Ser647 in response to CD28 costimulation. J Immunol 2008;180:222-9.
28. Vumbaca F, Phoenix KN, Rodriguez-Pinto D, Han DK, Claffey KP. Double-stranded RNA-binding protein regulates vascular endothelial growth factor mRNA stability, translation, and breast cancer angiogenesis. Mol Cell Biol 2008;28:772-83.
29. Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, et al. Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity. J Biol Chem 1999;274:34598-604.
30. Rosmarin AG, Resendes KK, Yang Z, McMillan JN, Fleming SL. GA-binding protein transcription factor: a review of GABP as an integrator of intracellular signaling and protein-protein interactions. Blood Cells Mol Dis 2004;32:143-54.
31. Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP. DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. J Biol Chem 1998;273:2136-45.
32. Tang J, Kao PN, Herschman HR. Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3. J Biol Chem 2000;275:19866-76.
33. Langland JO, Kao PN, Jacobs BL. Nuclear factor-90 of activated T-cells: a double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR. Biochemistry 1999;38:6361-8.
34. Aoki Y, Zhao G, Qiu D, Shi L, Kao PN. CsA-sensitive purine-box transcriptional regulator in bronchial epithelial cells contains NF45, NF90, and Ku. Am J Physiol 1998;275(6 Pt 1):L1164-72.
35. Avots A, Hoffmeyer A, Flory E, Cimanis A, Rapp UR, Serfling E. GABP factors bind to a distal interleukin 2 (IL-2) enhancer and contribute to c-Raf-mediated increase in IL-2 induction. Mol Cell Biol 1997;17:4381-9.
36. Hoffmeyer A, Avots A, Flory E, Weber CK, Serfling E, Rapp UR. The GABP-responsive element of the interleukin-2 enhancer is regulated by JNK/SAPK-activating pathways in T lymphocytes. J Biol Chem 1998;273:10112-9.
37. Gao B, Calhoun K, Fang D. The proinflammatory cytokines IL-1β and TNF-α induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway. Arthritis Res Ther 2006;8:R172.
38. Kaneko M, Yasui S, Niinuma Y, Arai K, Omura T, Okuma Y, et al. A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes. FEBS Lett 2007;581:5355-60.
39. Williams BR. Signal integration via PKR. Sci STKE 2001;2001:RE2.
40. Lee ES, Yoon CH, Kim YS, Bae YS. The double-strand RNA-dependent protein kinase PKR plays a significant role in a sustained ER stress-induced apoptosis. FEBS Lett 2007;581:4325-32.
41. Nakajima T, Uchida C, Anderson SF, Lee CG, Hurwitz J, Parvin JD, et al. RNA helicase A mediates association of CBP with RNA polymerase II. Cell 1997;90:1107-12.
42. Aratani S, Fujii R, Oishi T, Fujita H, Amano T, Ohshima T, et al. Dual roles of RNA helicase A in CREB-dependent transcription. Mol Cell Biol 2001;21:4460-9.
43. Kang HS, Nelson ML, Mackereth CD, Scharpf M, Graves BJ, McIntosh LP. Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABPα. J Mol Biol 2008;377:636-46.
44. Nakajima T, Aratani S, Nakazawa M, Hirose T, Fujita H, Nishioka K. Implications of transcriptional coactivator CREB binding protein complexes in rheumatoid arthritis. Mod Rheumatol 2004;14:6-11.
45. Takizawa T, Ochiai W, Nakashima K, Taga T. Enhanced gene activation by Notch and BMP signaling cross-talk. Nucleic Acids Res 2003;31:5723-31.