LC-MS/MS method for determination of hederacolchiside E, a neuroactive saponin from Pulsatilla koreana extract in rat plasma for pharmacokinetic study

Journal of Pharmaceutical and Biomedical Analysis

Volumn 48, Issue 5, 2008, Pages 1425-1429

  Yoo, Hye Hyun ^a   Lee, Sang Kyu ^a   Lim, Sun Young ^a   Kim, Yoon ^a   Kang, Min Jung ^a   Kim, Eun Jeong ^b   Park, Yang Hae ^b   Im, Guang Jin ^b   Lee, Bong Yong ^b   Kim, Dong Hyun ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b SK Chemicals   (South Korea)

Author keywords

Hederacolchiside E; LC MS MS; Pharmacokinetic study; Pulsatilla koreana; SK PC B70M

Indexed keywords

DIGOXIN; HEDERACOLCHISIDE E; PLANT EXTRACT; PULSATILLA KOREANA EXTRACT; SAPONIN DERIVATIVE; SK PC B70M; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; RAT;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; CALIBRATION; CHROMATOGRAPHY, LIQUID; DRUGS, CHINESE HERBAL; HALF-LIFE; MALE; MOLECULAR STRUCTURE; PLANT EXTRACTS; PULSATILLA; QUALITY CONTROL; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SAPONINS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TIME FACTORS;

EID: 58249097229     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.09.012     Document Type: Article

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