Spitz nevi: In vivo confocal microscopic features, dermatoscopic aspects, histopathologic correlates, and diagnostic significance

Journal of the American Academy of Dermatology

Volumn 60, Issue 2, 2009, Pages 236-247

  Pellacani, Giovanni ^a   Longo, Caterina ^a   Ferrara, Gerardo ^b   Cesinaro, Anna Maria ^a   Bassoli, Sara ^a   Guitera, Pascale ^c   Menzies, Scott W ^c   Seidenari, Stefania ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b G RUMMO HOSPITAL   (Italy)

^c SYDNEY CANCER CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER DIAGNOSIS; CELL STRUCTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOLOGY; DENDRITIC CELL; DIAGNOSTIC VALUE; EPILUMINESCENCE MICROSCOPY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IN VIVO STUDY; JUVENILE MELANOMA; MELANOCYTE; MELANOMA CELL; PARAKERATOSIS; PRIORITY JOURNAL;

DERMIS; DERMOSCOPY; DIAGNOSIS, DIFFERENTIAL; DYSPLASTIC NEVUS SYNDROME; EPIDERMIS; HUMANS; MELANOMA; MICROSCOPY, CONFOCAL; NEVUS, EPITHELIOID AND SPINDLE CELL; SKIN NEOPLASMS;

EID: 58149520144     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaad.2008.07.061     Document Type: Article

References (33)

1. Spitz S. Melanoma of childhood. Am J Pathol 24 (1948) 591-609
2. Reed R.J., Ichinose H., Clark Jr. W.H., and Mihm Jr. M.C. Common and uncommon melanocytic nevi and borderline melanomas. Semin Oncol 2 (1975) 119-147
3. Casso E.M., Grin-Jorgensen C.M., and Grant-Kels J.M. Spitz nevi. J Am Acad Dermatol 27 (1992) 901-913
4. Dal Pozzo V., Benelli C., Restano L., Gianotti R., and Cesana B.M. Clinical review of 247 case records of Spitz nevus (epithelioid cell and/or spindle cell nevus). Dermatology 194 (1997) 20-25
5. Ackerman A.B., and Magana-Garcia M. Naming acquired melanocytic nevi. Am J Dermatopathol 12 (1990) 193-209
6. Sau P., Graham J.H., and Helwig E.B. Pigmented spindle cell nevus: a clinicopathologic analysis of ninety-five cases. J Am Acad Dermatol 28 (1993) 565-571
7. Piepkorn M. On the nature of histologic observations: the case of the Spitz nevus. J Am Acad Dermatol 32 (1995) 248-254
8. Barnhill R.L., Barnhill M.A., Berwick M., and Mihm Jr. M.C. The histologic spectrum of pigmented spindle cell nevus: a review of 120 cases with emphasis on atypical variants. Hum Pathol 22 (1991) 52-58
9. Mones J.M., and Ackerman A.B. "Atypical" Spitz's nevus, "malignant" Spitz's nevus, and "metastasizing" Spitz's nevus: a critique in historical perspective of three concepts flawed fatally. Am J Dermatopathol 26 (2004) 310-333
10. Barnhill R.L. The Spitzoid lesion: rethinking Spitz tumors, atypical variants, 'Spitzoid melanoma' and risk assessment. Mod Pathol 19 Suppl (2006) S21-S33
11. Steiner A., Pehamberger H., Binder M., and Wolff K. Pigmented Spitz nevi: improvement of the diagnostic accuracy by epiluminescence microscopy. J Am Acad Dermatol 27 (1992) 697-701
12. Stolz W., Braun-Falco O., Bilek P., Landthaler M., and Cognetta A.B. Pigmented spindle-cell nevus and Spitz nevus. In: Stolz W., Braun-Falco O., Bilek P., Landthaler M., and Cognetta A.B. (Eds). Color atlas of dermatoscopy (1994), Blackwell Science Ltd, Oxford (United Kingdom) 66-70
13. Argenziano G., Soyer H.P., Ferrara G., Piccolo D., Hofmann-Wellenhof R., Peris K., et al. Superficial black network: an additional dermoscopic clue for the diagnosis of spindle and/or epithelioid cell nevus. Dermatology 203 (2001) 333-335
14. Argenziano G., Scalvenzi M., Staibano S., Brunetti B., Piccolo D., Delfino M., et al. Dermatoscopic pitfalls in differentiating pigmented Spitz nevi from cutaneous melanomas. Br J Dermatol 141 (1999) 788-793
15. Pellacani G., Cesinaro A.M., and Seidenari S. Morphological features of Spitz nevus as observed by digital videomicroscopy. Acta Derm Venereol 80 (2000) 117-121
16. Peris K., Ferrari A., Argenziano G., Soyer H.P., and Chimenti S. Dermoscopic classification of Spitz/Reed nevi. Clin Dermatol 20 (2002) 59-62
17. Brunetti B., Nino M., Sammarco E., and Scalvenzi M. Spitz nevus: a proposal for management. J Eur Acad Dermatol Venereol 19 (2005) 391-393
18. Ferrara G., Argenziano G., Soyer H.P., Chimenti S., Di Blasi A., Pellacani G., et al. The spectrum of Spitz nevi: a clinicopathologic study of 83 cases. Arch Dermatol 141 (2005) 1381-1387
19. González S., Gilaberte-Calzada Y., González-Rodríguez A., Torres A., and Mihm Jr. M.C. In vivo reflectance-mode confocal scanning laser microscopy in dermatology. Adv Dermatol 20 (2004) 371-387
20. Pellacani G., Guitera P., Longo C., Avramidis M., Seidenari S., and Menzies S. The impact of in vivo reflectance confocal microscopy for the diagnostic accuracy of melanoma and equivocal melanocytic lesions. J Invest Dermatol 127 (2007) 2759-2765
21. Pellacani G., Cesinaro A.M., Grana C., and Seidenari S. In vivo confocal scanning laser microscopy of pigmented Spitz nevi: comparison of in vivo confocal images with dermoscopy and routine histopathology. J Am Acad Dermatol 51 (2004) 371-376
22. Rajadhyaksha M., Gonzalez S., Zavislan J.M., Anderson R.R., and Webb R.H. In vivo confocal scanning laser microscopy of human skin II: advances in instrumentation and comparison with histology. J Invest Dermatol 113 (1999) 293-303
23. Argenziano G., Soyer H.P., Chimenti S., Talamini R., Corona R., Sera F., et al. Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet. J Am Acad Dermatol 48 (2003) 679-693
24. Scope A., Benvenuto-Andrade C., Agero A.L., Malvehy J., Puig S., Rajadhyaksha M., et al. In vivo reflectance confocal microscopy imaging of melanocytic skin lesions: consensus terminology glossary and illustrative images. J Am Acad Dermatol 57 (2007) 644-658
25. Pellacani G., Cesinaro A.M., and Seidenari S. Reflectance-mode confocal microscopy of pigmented skin lesions-improvement in melanoma diagnostic specificity. J Am Acad Dermatol 53 (2005) 979-985
26. Barnhill R.L., Argenyi Z.B., From L., Glass L.F., Maize J.C., Mihm Jr. M.C., et al. Atypical Spitz nevi/tumors: lack of consensus for diagnosis, discrimination from melanoma, and prediction outcome. Hum Pathol 30 (1999) 513-520
27. Urso C. Melanocytic lesions, Spitz tumors, and Don Ferrante's logic. Am J Dermatopathol 29 (2007) 491-494
28. Pizzichetta M.A., Argenziano G., Grandi G., de Giacomi C., Trevisan G., and Soyer H.P. Morphologic changes of a pigmented Spitz nevus assessed by dermoscopy. J Am Acad Dermatol 47 (2002) 137-139
29. Gerger A., Koller S., Weger W., Richtig E., Kerl H., Samonigg H., et al. Sensitivity and specificity of confocal laser-scanning microscopy for in vivo diagnosis of malignant skin tumors. Cancer 107 (2006) 193-200
30. Pellacani G., Cesinaro A.M., Longo C., Grana C., and Seidenari S. Microscopic in vivo description of cellular architecture of dermoscopic pigment network in nevi and melanomas. Arch Dermatol 141 (2005) 147-154
31. Scope A., Benvenuto-Andrade C., Agero A.L., Halpern A.C., Gonzalez S., and Marghoob A.A. Correlation of dermoscopic structures of melanocytic lesions to reflectance confocal microscopy. Arch Dermatol 143 (2007) 176-185
32. Pellacani G., Bassoli S., Longo C., Cesinaro A.M., and Seidenari S. Diving into the blue: in vivo microscopic characterization of the dermoscopic blue hue. J Am Acad Dermatol 57 (2007) 96-104
33. Pellacani G, Longo C, Malvehy J, Puig S, Carrera C, Segura S, et al. In vivo confocal microscopic and histopathologic correlations of dermoscopic features in 202 melanocytic lesions. Arch Dermatol. In press.