Microscopic in vivo description of cellular architecture of dermoscopic pigment network in nevi and melanomas

Archives of Dermatology

Volumn 141, Issue 2, 2005, Pages 147-154

  Pellacani, Giovanni ^a   Cesinaro, Anna Maria ^a   Longo, Caterina ^a   Grana, Costantino ^a   Seidenari, Stefania ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BASAL CELL; CANCER DIAGNOSIS; CELL INFILTRATION; CELL NUCLEUS; CLINICAL FEATURE; COMPUTER PROGRAM; CONFOCAL LASER MICROSCOPY; CYTOLOGY; DERMOEPIDERMAL JUNCTION; DIFFERENTIAL DIAGNOSIS; EPILUMINESCENCE MICROSCOPY; HUMAN; IN VIVO STUDY; MAJOR CLINICAL STUDY; MELANOMA; MORPHOLOGY; NEVUS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SKIN CELL; SKIN PIGMENTATION;

BIOPSY, NEEDLE; COHORT STUDIES; DERMOSCOPY; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MELANOCYTES; MELANOMA; MICROSCOPY, CONFOCAL; NEVUS, PIGMENTED; PROBABILITY; SAMPLING STUDIES; SENSITIVITY AND SPECIFICITY; SKIN NEOPLASMS; SKIN PIGMENTATION; STATISTICS, NONPARAMETRIC;

EID: 13444249535     PISSN: 0003987X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archderm.141.2.147     Document Type: Article

References (32)

1. Rajadhyaksha M, Grossman M, Esterowitz D, Webb RH, Anderson RR. In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast. J Invest Dermatol. 1995;104:946-952.
2. Rajadhyaksha M, Gonzalez S, Zavislan JM, Anderson RR, Webb RH. In vivo confocal scanning laser microscopy of human skin, II: advances in instrumentation and comparison with histology. J Invest Dermatol. 1999;113:293-303.
3. Sauermann K, Clemann S, Jaspers S, et al. Age related changes of human skin investigated with histometric measurements by confocal laser scanning microscopy in vivo. Skin Res Technol. 2002;8:52-56.
4. Huzaira M, Rius F, Rajadhyaksha M, Anderson RR, Gonzalez S. Topographic variations in normal skin, as viewed by in vivo reflectance confocal microscopy. J Invest Dermatol. 2001;116:846-852.
5. Gonzalez S, Rajadhyaksha M, Rubinstein G, Anderson RR. Characterization of psoriasis in vivo by reflectance confocal microscopy. J Med. 1999;30:337-356.
6. Gonzalez S, Rubinstein G, Mordovtseva V, Rajadhyaksha M, Anderson RR. In vivo abnormal keratinization in Darier-White's disease as viewed by real-time confocal imaging. J Cutan Pathol. 1999;26:504-508.
7. Gonzalez S, Gonzalez E, White MW, Rajadhyaksha M, Anderson RR. Allergic contact dermatitis: correlation of in vivo confocal imaging to routine histology. J Am Acad Dermatol. 1999;40:708-713.
8. Gonzalez S, Tannous Z. Real-time, in vivo confocal reflectance microscopy of basal cell carcinoma. J Am Acad Dermatol. 2002;47:869-874.
9. Hicks SP, Swindells KJ, Middelkamp-Hup MA, Sifakis MA, Gonzalez E, Gonzalez S. Confocal histopathology of irritant contact dermatitis in vivo and the impact of skin color (black vs white). J Am Acad Dermatol. 2003;48:727-734.
10. Busam KJ, Charles C, Lee G, Halpern AC. Morphological features of melanocytes, pigmented keratinocytes, and melanophages by in vivo confocal scanning laser microscopy. Mod Pathol. 2001;14:862-868.
11. Langley RG, Rajadhyaksha M, Dwyer PJ, Sober AJ, Flotte TJ, Anderson RR. Confocal scanning laser microscopy of benign and malignant melanocytic skin lesions in vivo. J Am Acad Dermatol. 2001;45:365-376.
12. Busam KJ, Hester K, Charles C, et al. Detection of clinically amelanotic malignant melanoma and assessment of its margins by in vivo confocal scanning laser microscopy. Arch Dermatol. 2001;137:923-929.
13. Busam KJ, Charles C, Lohmann CM, Marghoob A, Goldgeier M, Halpern AC. Detection of intraepidermal malignant melanoma in vivo by confocal scanning laser microscopy. Melanoma Res. 2002;12:349-355.
14. Tannous ZS, Mihm MC, Flotte TJ, Gonzalez S. In vivo examination of lentigo maligna and malignant melanoma in situ, lentigo maligna type by near-infrared reflectance confocal microscopy: comparison of in vivo confocal images with histologic sections. J Am Acad Dermatol. 2002;46:260-263.
15. Bafounta ML, Beauchet A, Aegerter P, Saiag P. Is dermoscopy (epiluminescence microscopy) useful for the diagnosis of melanoma? results of a meta-analysis using techniques adapted to the evaluation of diagnostic tests. Arch Dermatol. 2001;137:1343-1350.
16. Kittler H, Pehamberger H, Wolff K, Binder M. Diagnostic accuracy of dermoscopy. Lancet Dncol. 2002;3:159-165.
17. Soyer HP, Smolle J, Hodl S, Pachernegg H, Kerl H. Surface microscopy: a new approach to the diagnosis of cutaneous pigmented tumors. Am J Dermatopathol. 1989;11:1-10.
18. Yadav S, Vossaert KA, Kopf AW, Silverman M, Grin-Jorgensen C. Histopathologic correlates of structures seen on dermoscopy (epiluminescence microscopy). Am J Dermatopathol. 1993;15:297-305.
19. Soyer HP, Kenet RO, Wolf IH, Kenet BJ, Cerroni L. Clinicopathological correlation of pigmented skin lesions using dermoscopy. Eur J Dermatol. 2000;10:22-28.
20. Massi D, De Giorgi V, Carli P, Santucci M. Diagnostic significance of the blue hue in dermoscopy of melanocytic lesions: a dermoscopic-pathologic study. Am J Dermatopathol. 2001;23:463-469.
21. Massi D, De Giorgi V, Soyer HP. Histopathologic correlates of dermoscopic criteria. Dermatol Clin. 2001;19:259-268.
22. Pehamberger H, Steiner A, Wolff K. In vivo epiluminescence microscopy of pigmented skin lesions, I: pattern analysis of pigmented skin lesions. J Am Acad Dermatol. 1987;17:571-583.
23. Kenet RO, Kang S, Kenet BJ, Fitzpatrick TB, Sober AJ, Barnhill RL. Clinical diagnosis of pigmented lesions using digital epiluminescence microscopy: grading protocol and atlas. Arch Dermatol. 1993;129:157-174.
24. Pehamberger H, Binder M, Steiner A, Wolff K. In vivo epiluminescence microscopy: improvement of early diagnosis of melanoma. J Invest Dermatol. 1993;100:356S-362S.
25. Steiner A, Binder M, Schemper M, Wolff K, Pehamberger H. Statistical evaluation of epiluminescence microscopy criteria for melanocytic pigmented skin lesions. J Am Acad Dermatol. 1993;29:581-588.
26. Stanganelli I, Burroni M, Rafanelli S, Bucchi L. Intraobserver agreement in interpretation of digital epiluminescence microscopy. J Am Acad Dermatol. 1995;33:584-589.
27. Argenziano G, Soyer HP, Chimenti S, et al. Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet. J Am Acad Dermatol. 2003;48:679-693.
28. Seidenari S, Burroni M, Dell'Eva G, Pepe P, Belletti B. Computerized evaluation of pigmented skin lesion images recorded by a videomicroscope: comparison between polarizing mode observation and oil/slide mode observation. Skin Res Technol. 1995;1:187-191.
29. Pellacani G, Cesinaro AM, Grana C, Seidenari S. In vivo confocal scanning laser microscopy of pigmented Spitz nevi: comparison of in vivo confocal images with dermoscopy and routine histology. J Am Acad Dermatol. 2004;51:371-376.
30. Pellacani G, Cesinaro AM, Seidenari S. In-vivo confocal reflectance microscopy for the characterization of melanocytic nests and correlation with dermoscopy and histology. Br J Dermatol. In press.
31. Argenziano G, Fabbrocini G, Carli P, De Giorgi V, Sammarco E, Delfino M. Epiluminescence microscopy for the diagnosis of doubtful melanocytic skin lesions: comparison between the ABCD rule of dermatoscopy and a new 7-point checklist based on pattern analysis. Arch Dermatol. 1998;134:1563-1570.
32. Puppin D, Salomon D, Saurat JH. Amplified surface microscopy: preliminary evaluation of a 400-fold magnification in the surface microscopy of cutaneous melanocytic lesions. J Am Acad Dermatol. 1993;28:923-927.