Effects of leaves extract of Ocimum sanctum L. on arsenic-induced toxicity in Wistar albino rats

Food and Chemical Toxicology

Volumn 47, Issue 2, 2009, Pages 490-495

  Sharmila Banu, G ^a   Kumar, G ^b   Murugesan, A G ^b  

^a MUTHAYAMMAL COLLEGE OF ARTS AND SCIENCE   (India)

^b MANONMANIAM SUNDARANAR UNIVERSITY   (India)

Author keywords

Antioxidant property; Arsenic toxicity; Ocimum sanctum; Oxidative stress

Indexed keywords

ARSENIC; CATALASE; DRINKING WATER; GLUTATHIONE; OCIMUM SANCTUM EXTRACT; PLANT EXTRACT; PORPHOBILINOGEN SYNTHASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BASIL; BRAIN; CHELATION; CONTROLLED STUDY; ENZYME ACTIVITY; KIDNEY; LIVER; MALE; NONHUMAN; OXIDATIVE STRESS; PLANT LEAF; RAT; WATER CONTAMINATION;

ANIMALS; ANTIOXIDANTS; ARSENIC POISONING; ARSENITES; GLUTATHIONE; HEMATOPOIESIS; KIDNEY; LIVER; OCIMUM; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PORPHOBILINOGEN SYNTHASE; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SODIUM COMPOUNDS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

ANIMALIA; OCIMUM TENUIFLORUM; RATTUS;

EID: 58149517977     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.12.004     Document Type: Article

References (62)

1. Agrawal P., Rai V., and Singh R.B. Randomized placebo-controlled, single blind trial of holy basil leaves in patients with non-insulin dependent diabetes mellitus. Int. J. Clin. Pharmacol. Ther. 34 (1996) 406-409
2. Aposhian H.V., and Aposhian M.M. Meso-2,3-dimercapto-succinic acid: chemical, pharmacological and toxicological properties of an orally effective metal chelating agent. Ann. Rev. Pharmacol. Toxicol. 30 (1990) 279-306
3. Berlin A., and Schaller K.H. European standardized method for the determination of δ-aminolevulinic acid dehydratase activity in blood. Zeit. Klin. Chem. Klin. Biochem. 12 (1974) 389-390
4. Bhadauria S., and Flora S.J.S. Arsenic induced inhibition of δ-aminolevulinic acid dehydratase activity in rat blood and its response to meso-2,3-dimercaptosuccinic acid and monoisoamyl DMSA. Biomed. Environ. Sci. 17 (2003) 305-313
5. Bhargava K.P., and Singh N. Anti-stress activity of Ocimum sanctum. Ind. J. Med. Res. 73 (1981) 443-451
6. Chan P.C., and Huff J. Arsenic carcinogenesis in animals and in humans; mechanistic experimental and epidemiological evidence. Environ. Carcino. Ecotox. Revs. C15 (1997) 83-122
7. Chattopadhyay R.R. Hypoglycemic effect of Ocimum sanctum leaf extract in normal and streptozotocin diabetic rats. Ind. J. Exp. Biol. 31 (1993) 891-893
8. Dastur J.F. Medicinal Plants of India and Pakistan (1962), DB Taraporevala Sons & Co., Bombay, India p. 43
9. Devi P.U., and Ganasoundari A. Modulation of glutathione and antioxidant enzymes by Ocimum sanctum and its role in protection against radiation injury. Ind. J. Exp. Biol. 37 (1999) 262-268
10. Dhar M.L., Dhar M.M., and Dhawan B.N. Screening of Indian plants for biological activity Part I. Ind. J. Exp. Biol. 6 (1968) 232-247
11. Flohe L., and Gunzler W.A. Assays of glutathione peroxidase. Meth. Enzymol. 105 (1984) 114-121
12. Flora S.J.S. Arsenic induced oxidative stress and its reversibility following combined administration of N-acetylcysteine and meso-2,3-dimercaptosuccinic acid in rats. Clin. Exp. Pharmacol. Physiol. 26 (1999) 865-869
13. Flora S.J.S. Nutritional components modify metal absorption, toxic response and chelation therapy. J. Nutr. Environ. Med. 12 (2002) 53-67
14. Flora S.J.S., and Tripathi N. Hepatic and renal metallothionein induction following single oral administration of gallium arsenide in rats. Biochem. Mol. Biol. Int. 45 (1998) 1121-1127
15. Ganasoundari A., Devi P.U., and Rao B.S. Enhancement of bone marrow radioprotection and reduction of WR-2721 toxicity by Ocimum sanctum. Mutat. Res. 397 (1998) 303-312
16. Ganasoundari A., Devi P.U., and Rao M.N.A. Protection against radiation-induced chromosome damage in mouse bone marrow by Ocimum sanctum. Mutat. Res. 373 (1997) 271-276
17. Ganasoundari A., Zare S.M., and Devi P.U. Modification of bone marrow radiosensitivity by medicinal plant extracts. Brit. J. Radiol. 70 (1997) 599-602
18. Goering P.L., Maronpot R.R., and Fowler B.A. Effect of intratracheal gallium arsenide administration on δ-aminolevulinic acid dehydratase in rats: relationship to urinary excretion of aminolevulinic acid. Toxicol. Appl. Pharmacol. 92 (1988) 179-193
19. Gupta R., and Flora S.J.S. Protective value of Aloe vera against some toxic effects of arsenic in rats. Phytother. Res. 19 (2005) 23-28
20. Gupta S.K., Prakash J., and Srivastava S. Validation of traditional claim of Tulasi, Ocimum sanctum Linn. as a medicinal plant. Ind. J. Exp. Biol. 40 (2002) 765-773
21. Hei T.K., Liu S.X., and Waldren C. Mutagenicity of arsenic in mammalian cells; role of reactive oxygen species. Proc. Natl. Acad. Sci. USA 95 (1998) 8103-8107
22. Hissin P.J., and Hilf R. A fluorometric method for the determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 74 (1973) 214-216
23. Joglekar G.V., Chaudhary N.Y., and Aiman R. Effect of indigenous plant extracts on glucose-absorption in mice. Ind. J. Physiol. Pharmacol. 3 (1959) 76-77
24. Jollow D.J., Mitchell J.R., Zamppaglione Z., and Gillette J.R. Bromobenzene induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolites. Pharmacology 11 (1974) 151
25. Kakkar P., Das B., and Viswanathan P.N. A modified spectrophotometric assay of superoxide dismutase. Ind. J. Biochem. Biophys. 21 (1984) 130-132
26. Kannan G.M., and Flora S.J.S. Chronic arsenic poisoning in the rats: treatment with combined administration of succimers and an antioxidants. Ecotoxicol. Environ. Saf. 58 (2004) 37-43
27. Khanna S., Gupta S.R., and Grover J.K. Effect of long term feeding of tulasi (Ocimum sanctum Linn.) on reproductive performance of adult albino rats. Ind. J. Exp. Biol. 24 (1986) 302-304
28. Kirtikar K., and Basu B. Indian Medicinal Plants (1993), Periodical Expert Book Agency, New Delhi, India pp. 3-6
29. Kitchin K.T. Recent advances in arsenic carcinogenesis: mode of action, animal model system and methylated arsenic metabolites. Toxicol. Appl. Pharmacol. 172 (2001) 249-261
30. Koleva I.I., Van Black T.A., Linssen J.P., De-Groot A., and Evastatieva L.N. Screening of plant extracts for antioxidant activity: a comparative study on three testing methods. Phytochem. Anal. 13 (2002) 8-17
31. Lian F.W., and Jian Z.H. Chronic arsenism for drinking water in some areas of Xingjian, China. In: Nriagu J.O. (Ed). Arsenic in the Environment. Part II: Human Health and Ecosystem Effects (1994), John Wiley & Sons Inc., New York 159-172
32. Liu J. Pharmacology of oleanolic acid and ursolic acid. J. Ethnopharmacol. 49 (1995) 57-68
33. Liu S.X., Athar M., Lippai I., Waldren C., and Hei T.K. Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity. Proc. Natl. Acad. Sci. USA 98 (2001) 1643-1648
34. Lynn S., Shiung J.N., Gurr J.R., and Jan K.Y. Arsenic stimulates poly (ADP-ribosylation) by generation of nitric oxide. Free Rad. Biol. Med. 24 (1998) 442-449
35. Mandal B.K., Biswas B.K., Dhar R.K., Roy Chowdhury T., Samanta G., Basu G.K., Chanda C.R., Saha K.C., Kabir S., Roy S., and Chakraborti D. Ground water arsenic contamination and suffering of people in West Bengal, India and Bangladesh: status report up to March 1998. In: Sarkar B. (Ed). Metal and Genetics (1999), Plenum Corporation, New York 41-66
36. Mehta A., and Flora S.J.S. Possible role of metal redistribution, hepatotoxicity and oxidative stress in chelating agents induced hepatic and renal metallothionein in rats. Food Chem. Toxicol. 39 (2001) 1039-1043
37. Modi M., Pathak U., Kalia K., and Flora S.J.S. Arsenic antagonism studies with monoisoamyl DMSA and zinc in male mice. Environ. Toxicol. Pharmacol. 19 (2005) 131-138
38. National Institute of Health Guide for the Care and Use of laboratory Animals, 1985. DHEW Publication (NIH), revised, Office of Science and Health Reports, DRR/NIH, Bethesda, USA.
39. Nocentini S., Guggiari M., Rouillard D., and Surges S. Exacerbating effect of vitamin E supplementation on DNA damage induced in cultured human normal fibroblasts by UVA radiation. Phytochem. Phytobiol. 73 (2001) 370-377
40. Onkawa H., Ohishi N., and Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95 (1979) 351-358
41. Onosaka S., and Cherian M.G. Comparison of metallothionein determination by polarographic and cadmium-saturation methods. Toxicol. Appl. Pharmacol. 63 (1982) 270-274
42. Pande M., and Flora S.J.S. Lead induced oxidative damage and its response to combined administration of - lipoic acid and succimers in rats. Toxicology 177 (2002) 187-196
43. Phippen W.B., and Simon J.E. Anthocyanins in basil. J. Agric. Food Chem. (1998) 1734-1738
44. Rai V., Iyer U., and Mani U.V. Effect of Tulasi (Ocimum sanctum) leaf powder supplementation on blood sugar levels, serum lipids and tissue lipids in diabetic rats. Plant Food Human Nutr. 50 (1997) 9-16
45. Ramnathan K., Balakumar B.S., and Panneerselvam C. Effects of ascorbic acid and α-tocopherol on arsenic-induced oxidative stress. Human Exp. Toxicol. 21 (2002) 675-680
46. Gupta R., Kannan G.M., Sharma M., and Flora S.J.S. Therapeutic effects of Moringa oleifera on arsenic-induced toxicity in rats. Environ. Toxicol. Pharmacol. 20 (2005) 456-464
47. Saxena G., and Flora S.J.S. Lead induced oxidative stress and haematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats. J. Biochem. Mol. Toxicol. 18 (2004) 221-233
48. Seth S.D., Johri N., and Sundaram K.R. Antispermatogenic effect of Ocimum sanctum. Ind. J. Exp. Biol. 19 (1981) 975-976
49. Shyamala A.C., and Devaki T. Studies on peroxidation in rats ingesting copper sulphate and effect of subsequent treatment with Ocimum sanctum. J. Clin. Biochem. Nutr. 20 (1996) 113-119
50. Singh N., Mishra N., and Srivastava A.K. Effect of antistress plants on biochemical changes during stress reactions. Ind. J. Pharmacol. 23 (1991) 137-142
51. Singh N., Nath R., and Gupta M.L. An experimental evaluation of anti-asthmatic potential of Inula racemosa. Quart. J. Crude Drug Res. 18 (1980) 86-96
52. Singh N., Verma P., and Mishra N. A comparative evaluation of some antistress agents of plant origin. Ind. J. Pharmacol. 23 (1991) 99-103
53. Sinha A.K. Colorimetric assay of catalase. Anal. Biochem. 47 (1972) 389-394
54. Smith A.H., Lingas E.O., and Rahman M. Contamination of drinking water of arsenic in Bangladesh. Bull. World Health Org. 78 (2000) 1093-1103
55. Smith A.H., and Smith M.M.H. Arsenic drinking water regulation in developing countries with extensive exposure. Toxicology 198 (2004) 39-44
56. Socci D.J., Bjugstad K.B., Jones H.C., Pattisapu J.V., and Arendash G.W. Evidence that oxidative stress is associated with the pathophysiology of inherited hydrocephalus in the H-Tx rat model. Exp. Neurol. 155 (1999) 109-117
57. Thomas D.J., Styblo M., and Lin S. The cellular metabolism and systemic toxicity of arsenic. Toxicol. Appl. Pharmacol. 176 (2001) 127-144
58. Vats V., Yadav S.P., and Grover J.K. Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats. J. Ethnopharmacol. 90 (2004) 155-160
59. Wagner H., Norr H., and Winterhoff H. Plant adaptogens. Phytomedicine 1 (1994) 63-76
60. Wang T.S., Shu Y.F., Liu Y.C., Jan K.Y., and Huang H. Glutathione peroxidase and catalase modulate the genotoxicity of arsenite. Toxicology 121 (1997) 229-237
61. Warier P.K. Ocimum basilicum Linn. In: Warrier P.K., Nambiar V.P.K., and Ramankutty C. (Eds). Indian Medicinal Plants (1995), Orient Longman Limited, Madras, India 160-163
62. Yang C.Y., Chang C.C., Tsai S.S., Chaung H.Y., Ho C.K., and Wu T.N. Arsenic in drinking water and adverse pregnancy outcome in an arseniasis-endemic area in Northeastern Taiwan. Environ. Res. 91 (2003) 29-34