Endothelin-1 stimulates human adipocyte lipolysis through the ET A receptor

International Journal of Obesity

Volumn 33, Issue 1, 2009, Pages 67-74

  Eriksson, A K S ^a   Van Harmelen, V ^a   Stenson, B M ^a   Astrom G ^a   Wahlen K ^a   Laurencikiene, J ^a   Ryden M ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Adipocyte; Endothelin; Lipolysis; mRNA; Protein

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; MESSENGER RNA;

ADIPOCYTE; ADIPOSE TISSUE; ADULT; AGED; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CELL STIMULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INCUBATION TIME; LEAN BODY WEIGHT; LIPOLYSIS; LIVING DONOR; MAJOR CLINICAL STUDY; MALE; OBESITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SUBCUTANEOUS FAT; WESTERN BLOTTING;

ADIPOCYTES; ADIPOSE TISSUE; ADULT; AGED; CASE-CONTROL STUDIES; CELLS, CULTURED; ENDOTHELIN-1; ENDOTHELINS; FEMALE; HUMANS; INSULIN RESISTANCE; LIPOLYSIS; MALE; MIDDLE AGED; OBESITY; PEPTIDE FRAGMENTS; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STIMULATION, CHEMICAL; SUBCUTANEOUS FAT;

EID: 58149496358     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2008.212     Document Type: Article

References (26)

1. Fantuzzi G, Mazzone T. Adipose tissue and atherosclerosis: exploring the connection. Arterioscler Thromb Vasc Biol 2007; 27: 996-1003.
2. Sowers JR. Obesity as a cardiovascular risk factor. Am J Med 2003; 115 (Suppl 8A): 37S-41S.
3. Arner P. The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones. Trends Endocrinol Metab 2003; 14: 137-145.
4. Arner P. Human fat cell lipolysis: biochemistry, regulation and clinical role. Best Pract Res Clin Endocrinol Metab 2005; 19: 471-482.
5. Langin D. Control of fatty acid and glycerol release in adipose tissue lipolysis. C R Biol 2006; 329: 598-607; discussion 653-555.
6. Sokolovsky M. Endothelin receptor subtypes and their role in transmembrane signaling mechanisms. Pharmacol Ther 1995; 68: 435-471.
7. Bouallegue A, Daou GB, Srivastava AK. Endothelin-1-induced signaling pathways in vascular smooth muscle cells. Curr Vasc Pharmacol 2007; 5: 45-52.
8. Sokolovsky M. Endothelin receptor heterogeneity, G-proteins, and signaling via cAMP and cGMP cascades. Cell Mol Neurobiol 1995; 15: 561-571.
9. Juan CC, Chang CL, Lai YH, Ho LT. Endothelin-1 induces lipolysis in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 2005; 288: E1146-E1152.
10. van Harmelen V, Eriksson A, Astrom G, Wahlen K, Naslund E, Karpe F et al. Vascular peptide endothelin-1 links fat accumulation with alterations of visceral adipocyte lipolysis. Diabetes 2008; 57: 378-386.
11. Juan CC, Chang LW, Huang SW, Chang CL, Lee CY, Chien Y et al. Effect of endothelin-1 on lipolysis in rat adipocytes. Obesity (Silver Spring) 2006; 14: 398-404.
12. Ryden M, Arner P. Fat loss in cachexia - is there a role for adipocyte lipolysis? Clin Nutr 2007; 26: 1-6.
13. Arner P, Stenson BM, Dungner E, Naslund E, Hoffstedt J, Ryden M et al. Expression of STAMP2 in human adipose tissue associates with adiposity and insulin resistance. J Clin Endocrinol Metab 2008; 93: 2249-2254.
14. van Harmelen V, Skurk T, Hauner H. Primary culture and differentiation of human adipocyte precursor cells. Methods Mol Med 2005; 107: 125-135.
15. Mairal A, Langin D, Arner P, Hoffstedt J. Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity. Diabetologia 2006; 49: 1629-1636.
16. Hellmer J, Marcus C, Sonnenfeld T, Arner P. Mechanisms for differences in lipolysis between human subcutaneous and omental fat cells. J Clin Endocrinol Metab 1992; 75: 15-20.
17. Ryden M, Dicker A, van Harmelen V, Hauner H, Brunnberg M, Perbeck L et al. Mapping of early signaling events in tumor necrosis factor-alpha-mediated lipolysis in human fat cells. J Biol Chem 2002; 277: 1085-1091.
18. Ryden M, Jocken J, van Harmelen V, Dicker A, Hoffstedt J, Wiren M et al. Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis. Am J Physiol Endocrinol Metab 2007; 292: E1847-E1855.
19. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-408.
20. Ferri C, Bellini C, Desideri G, Baldoncini R, Properzi G, Santucci A et al. Circulating endothelin-1 levels in obese patients with the metabolic syndrome. Exp Clin Endocrinol Diabetes 1997; 105 (Suppl 2): 38-40.
21. Haak T, Jungmann E, Felber A, Hillmann U, Usadel KH. Increased plasma levels of endothelin in diabetic patients with hypertension. Am J Hypertens 1992; 5: 161-166.
22. Parrinello G, Scaglione R, Pinto A, Corrao S, Cecala M, Di Silvestre G et al. Central obesity and hypertension: the role of plasma endothelin. Am J Hypertens 1996; 9: 1186-1191.
23. Schneider JG, Tilly N, Hierl T, Sommer U, Hamann A, Dugi K et al. Elevated plasma endothelin-1 levels in diabetes mellitus. Am J Hypertens 2002; 15: 967-972.
24. Touyz RM, Schiffrin EL. Role of endothelin in human hypertension. Can J Physiol Pharmacol 2003; 81: 533-541.
25. Ryden M, Arner P. Tumour necrosis factor-alpha in human adipose tissue - from signalling mechanisms to clinical implications. J Intern Med 2007; 262: 431-438.
26. Rossi GP, Andreis PG, Colonna S, Albertin G, Aragona F, Belloni AS et al. Endothelin-1[1-31]: a novel autocrine-paracrine regulator of human adrenal cortex secretion and growth. J Clin Endocrinol Metab 2002; 87: 322-328.