Dickkopf-like 1 regulates postpubertal spermatocyte apoptosis and testosterone production

Endocrinology

Volumn 150, Issue 1, 2009, Pages 404-

  Dakhova, Olga ^a   O'Day, Diana ^b   Kinet, Noe ^c   Yucer, Nur ^a   Wiese, Mary ^a   Shetty, Gunapala ^b   Ducy, Patricia ^a,c  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c Howard Hughes Medical Institute

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYTOCHROME P450 17; DICKKOPF 1 PROTEIN; DNA; FAS LIGAND; FIBRINOGEN; STEROIDOGENIC FACTOR 1; TESTOSTERONE; DKK1 PROTEIN, MOUSE; FASL PROTEIN, MOUSE; RNA; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA BINDING; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HOMEOSTASIS; HORMONE DETERMINATION; HORMONE SYNTHESIS; LEYDIG CELL; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPERMATOCYTE; SPERMATOZOON COUNT; STEROIDOGENESIS; TESTIS; TRANSCRIPTION INITIATION; ANIMAL; BIOSYNTHESIS; CYTOLOGY; GENETIC TRANSFECTION; GENETICS; ISOLATION AND PURIFICATION; MOUSE MUTANT; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PUBERTY;

ANIMALS; APOPTOSIS; FAS LIGAND PROTEIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; PUBERTY; RNA; SPERM COUNT; SPERMATOCYTES; TESTOSTERONE; TRANSFECTION;

EID: 58149478500     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-0673     Document Type: Article

References (38)

1. Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA 1999 Functional and structural diversity of the human Dickkopf gene family. Gene 238:301-313
2. Bafico A, Liu G, Yaniv A, Gazit A, Aaronson SA 2001 Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol 7:683-686
3. Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C 2001 LDL- receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411: 321-325
4. Semenov MV, Tamai K, Brott BK, Kuhl M, Sokol S, He X 2001 Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol 12:951-961
5. Li L, Mao J, Sun L, Liu W, Wu D 2002 Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J Biol Chem 277:5977-5981
6. Brott BK, Sokol SY 2002 Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins. Mol Cell Biol 22:6100-6110
7. Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C 1998 Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391:357-362
8. Kaneko KJ, DePamphilis ML 2000 Soggy, a spermatocyte-specific gene, lies 3.8 kb upstream of and antipodal to TEAD-2, a transcription factor expressed at the beginning of mouse development. Nucleic Acids Res 28:3982-3990
9. Kaneko KJ, Rein T, Guo ZS, Latham K, DePamphilis ML 2004 DNA methylation may restrict but does not determine differential gene expression at the Sgy/Tead2 locus during mouse development. Mol Cell Biol 24:1968-1982
10. Kohn MJ, Kaneko KJ, DePamphilis ML 2005 DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian sperma to genes is. Mol Reprod Dev 71:516-522
11. Sambrook J, Fritsch EF, Alaniatis T 1989 Molecular cloning: a laboratory manual. 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
12. Wreford NG 1995 Theory and practice of stereological techniques applied to the estimation of cell number and nuclear volume in the testis. Microsc Res Tech 32:423-436
13. Russell LD, Attlin R, Sinha Hikim A, Clegg E 1990 In: Russell LD, Attlin R, Sinha Hikim A, Clegg E, eds. Histological and histopathological evaluation of the testis. Clearwater, FL: Cache River Press; 62-118
14. Weibel ER 1979-1980 Stereological methods. New York: Academic Press
15. Ariyaratne HB, Mendis-Handagama SM, Mason Jl 2000 Effects of tri-iodothyronine on testicular interstitial cells and androgen secretory capacity of the prepubertal Rat. Biol Reprod 63:493-502
16. Ducy P, Karsenty G 1995 Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol Cell Biol 15:1858-1869
17. Dignam JD, Lebovitz RM, Roeder RG 1983 Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489
18. Knudson CM, Tung KS, Tourtellotte WG, Brown GA, Korsmeyer SJ 1995 Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270:96-99
19. Rodriguez I, Ody C, Araki K, Garcia I, Vassalli P 1997 An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis. EMBO J 16:2262-2270
20. Baum JS, St George JP, McCall K 2005 Programmed cell death in the germline. Semin Cell Dev Biol 16:245-259
21. Lee J, Richburg JH, Younkin SC, Boekelheide K 1997 The Fas system is a key regulator of germ cell apoptosis in the testis. Endocrinology 138:2081-2088
22. Nair R, Shaha C 2003 Diethylstilbestrol induces rat spermatogenic cell apoptosis in vivo through increased expression of spermatogenic cell Fas/FasL system. J Biol Chem 278:6470-6481
23. Yao PL, Lin YC, Sawhney P, Richburg JH 2007 Transcriptional regulation of FasL expression and participation of sTNF-α in response to Sertoli cell injury. J Biol Chem 282:5420-5431
24. Koji T, Hishikawa Y, Ando H, Nakanishi Y, Kobayashi N 2001 Expression of Fas and Fas ligand in normal and ischemia-reperfusion testes: involvement of the Fas system in the induction of germ cell apoptosis in the damaged mouse testis. Biol Reprod 64:946-954
25. Kenneth PR 2005 Sertoli cell lines. In: Skinner MK, Griswold MD, eds. Sertoli cell biology. San Diego: Academic Press; 329-342
26. Mather JP 1980 Establishment and characterization of two distinct mouse testicular epithelial cell lines. Biol Reprod 23:243-252
27. Nagata S, Golstein P 1995 The Fas death factor. Science 267:1449-1456
28. Richburg JH, Nanez A, Williams LR, Embree ME, Boekelheide K 2000 Sensitivity of testicular germ cells to toxicant-induced apoptosis in gld mice that express a nonfunctional form of Fas ligand. Endocrinology 141:787-793
29. Parker KL, Rice DA, Lala DS, Ikeda Y, Luo X, Wong M, Bakke M, Zhao L, Frigeri C, Hanley NA, Stallings N, Schimmer BP 2002 Steroidogenic factor 1: an essential mediator of endocrine development. Recent Prog Horm Res 57:19-36
30. Val P, Lefrancois-Martinez AM, Veyssiere G, Martinez A 2003 A SF-1 a key player in the development and differentiation of steroidogenic tissues. Nucl Recept 1:8
31. Pezzi V, Sirianni R, Chimento A, Maggiolini M, Bourguiba S, Delalande C, Carreau S, Ando S, Simpson ER, Clyne CD 2004 Differential expression of steroidogenic factor-1/adrenal 4 binding protein and liver receptor homolog-1 (LRH-1)/fetoprotein transcription factor in the rat testis: LRH-1 as a potential regulator of testicular aromatase expression. Endocrinology 145:2186-2196
32. Cammas FM, Pullinger GD, Barker S, Clark AJ 1997 The mouse adrenocorticotropin receptor gene: cloning and characterization of its promoter and evidence for a role for the orphan nuclear receptor steroidogenic factor 1. Mol Endocrinol 11:867-876
33. Hammer GD, Krylova I, Zhang Y, Darimont BD, Simpson K, Weigel NL, Ingraham HA 1999 Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress. Mol Cell 3:521-526
34. Miller JR, Hocking AM, Brown JD, Moon RT 1999 Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways. Oncogene 18:7860-7872
35. Lee J, Richburg JH, Shipp EB, Meistrich ML, Boekelheide K 1999 The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis. Endocrinology 140: 852-858
36. Racine C, Rey R, Forest MG, Louis F, Ferre A, Huhtaniemi I, Josso N, di Clemente N 1998 Receptors for anti-mullerian hormone on Leydig cells are responsible for its effects on steroidogenesis and cell differentiation. Proc Natl Acad Sci USA 95:594-599
37. Levy S, Serre V, Hermo L, Robaire B 1999 The effects of aging on the seminiferous epithelium and the blood-testis barrier of the Brown Norway rat. J Androl 20:356-365
38. Meng J, Holdcraft RW, Shima JE, Griswold MD, Braun RE 2005 Androgens regulate the permeability of the blood-testis barrier. Proc Natl Acad Sci USA 102:16696-16700