Toll-like receptors and cytokines as surrogate biomarkers for evaluating vaginal immune response following microbicide administration

Mediators of Inflammation

Volumn 2008, Issue , 2008, Pages

  Gupta, Sadhana M ^a   Aranha, Clara C ^a   Mohanty, Madhu C ^a   Reddy, K V R ^a  

^a NATIONAL INSTITUTE FOR RESEARCH IN REPRODUCTIVE HEALTH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; MICROBICIDE; NISIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; ANTIINFECTIVE AGENT; DEFENSIN; TRANSCRIPTION FACTOR RELA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; FEMALE; IMMUNE RESPONSE; IMMUNOTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RABBIT; SIGNAL TRANSDUCTION; UPREGULATION; VAGINA; VAGINA EPITHELIUM; ANIMAL; CELL CULTURE; CYTOLOGY; EPITHELIUM CELL; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MUCOSAL IMMUNITY; PHYSIOLOGY;

ORYCTOLAGUS CUNICULUS;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOLOGICAL MARKERS; CELLS, CULTURED; CYTOKINES; DEFENSINS; EPITHELIAL CELLS; FEMALE; HUMANS; IMMUNITY, MUCOSAL; NISIN; RABBITS; TOLL-LIKE RECEPTORS; TRANSCRIPTION FACTOR RELA; VAGINA;

EID: 58149476742     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2008/534532     Document Type: Article

References (40)

1. Trifonova R. T., Pasicznyk J.-M., Fichorova R. N., Biocompatibility of solid-dosage forms of anti-human immunodeficiency virus type 1 microbicides with the human cervicovaginal mucosa modeled ex vivo Antimicrobial Agents and Chemotherapy 2006 50 12 4005 4010
2. Fichorova R. N., Zhou F., Ratnam V., Anti-human immunodeficiency virus type 1 microbicide cellulose acetate 1,2-benzenedicarboxylate in a human in vitro model of vaginal inflammation Antimicrobial Agents and Chemotherapy 2005 49 1 323 335
3. Alfano M., Poli G., The cytokine network in HIV infection Current Molecular Medicine 2002 2 8 677 689
4. Stone A., Microbicides: the UNAIDS-sponsored trial of nonoxynol-9 gel IPPF Medical Bulletin 2000 34 3 3 4
5. Rowe P. M., Nonoxynol-9 fails to protect against HIV-1 The Lancet 1997 349 9058 1074
6. Stafford M. K., Ward H., Flanagan A., Safety study of nonoxynol-9 as a vaginal microbicide: evidence of adverse effects Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 1998 17 4 327 331
7. Dayal M. B., Wheeler J., Williams C. J., Barnhart K. T., Disruption of the upper female reproductive tract epithelium by nonoxynol-9 Contraception 2003 68 4 273 279
8. Reddy K. V. R., Aranha C., Gupta S. M., Yedery R. D., Evaluation of antimicrobial peptide nisin as a safe vaginal contraceptive agent in rabbits: in vitro and in vivo studies Reproduction 2004 128 1 117 126
9. Reddy K. V. R., Yedery R. D., Aranha C., Antimicrobial peptides: premises and promises International Journal of Antimicrobial Agents 2004 24 6 536 547
10. Breukink E., de Kruijff B., The lantibiotic nisin, a special case or not? Biochimica et Biophysica Acta 1999 1462 1-2 223 234
11. Hansen J. N., Strohl W. R., Nisin and related antimicrobial peptides Biotechnology of Antibiotics 1997 New York, NY, USA Marcel Dekker 437 470
12. Aranha C. C., Gupta S. M., Reddy K. V. R., Assessment of cervicovaginal cytokine levels following exposure to microbicide Nisin gel in rabbits Cytokine 2008 43 1 63 70
13. Bäckhed F., Hornef M., Toll-like receptor 4-mediated signaling by epithelial surfaces: necessity or threat? Microbes and Infection 2003 5 11 951 959
14. Basu S., Fenton M. J., Toll-like receptors: function and roles in lung disease American Journal of Physiology 2004 286 5 L887 L892
15. Bowie A., O'Neill L. A. J., The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products Journal of Leukocyte Biology 2000 67 4 508 514
16. Du X., Poltorak A., Wei Y., Beutler B., Three novel mammalian toll-like receptors: gene structure, expression, and evolution European Cytokine Network 2000 11 3 362 371
17. Chuang T.-H., Ulevitch R. J., Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells Biochimica et Biophysica Acta 2001 1518 1-2 157 161
18. Gay N. J., Keith F. J., Drosophila Toll and IL-1 receptor Nature 1991 351 6325 355 356
19. Takeda K., Akira S., Toll-like receptors in innate immunity International Immunology 2005 17 1 1 14
20. Uematsu S., Akira S., Toll-like receptors and innate immunity Journal of Molecular Medicine 2006 84 9 712 725
21. Yao X.-D., Fernandez S., Kelly M. M., Kaushic C., Rosenthal K. L., Expression of Toll-like receptors in murine vaginal epithelium is affected by the estrous cycle and stromal cells Journal of Reproductive Immunology 2007 75 2 106 119
22. Abrahams V. M., Toll-like receptors in the cycling female reproductive tract and during pregnancy Current Women's Health Reviews 2005 1 1 35 42
23. Fichorova R. N., Bajpai M., Chandra N., Interleukin (IL)-1, IL-6 and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives Biology of Reproduction 2004 71 3 761 769
24. Gupta S. M., Aranha C. C., Reddy K. V. R., Evaluation of developmental toxicity of microbicide Nisin in rats Food and Chemical Toxicology 2008 46 2 598 603
25. Wira C. R., Fahey J. V., Sentman C. L., Pioli P. A., Shen L., Innate and adaptive immunity in female genital tract: cellular responses and interactions Immunological Reviews 2005 206 1 306 335
26. Tabibzadeh S., Ubiquitous expression of TNF- α /cachectin immunoreactivity in human endometrium American Journal of Reproductive Immunology 1991 26 1 1 4
27. Neurath A. R., Strick N., Li Y.-Y., Anti-HIV-1 activity of anionic polymers: a comparative study of candidate microbicides BMC Infectious Diseases 2002 2, article 27 1 11
28. Lard-Whiteford S. L., Matecka D., O'Rear J. J., Yuen I. S., Litterst C., Reichelderfer P., Recommendations for the nonclinical development of topical microbicides for prevention of HIV transmission: an update Journal of Acquired Immune Deficiency Syndromes 2004 36 1 541 552
29. Keller M. J., Guzman E., Hazrati E., PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity AIDS 2007 21 4 467 476
30. Cole A. M., Cole A. L., Antimicrobial polypeptides are key anti-HIV-1 effector molecules of cervicovaginal host defense American Journal of Reproductive Immunology 2008 59 1 27 34
31. Alexopoulou L., Holt A. C., Medzhitov R., Flavell R. A., Recognition of double-stranded RNA and activation of NF- κ B by Toll-like receptor 3 Nature 2001 413 6857 732 738
32. Fazeli A., Bruce C., Anumba D. O., Characterization of Toll-like receptors in the female reproductive tract in humans Human Reproduction 2005 20 5 1372 1378
33. Fichorova R. N., Cronin A. O., Lien E., Anderson D. J., Ingalls R. R., Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of Toll-like receptor 4-mediated signaling The Journal of Immunology 2002 168 5 2424 2432
34. Köllisch G., Kalali B. N., Voelcker V., Various members of the Toll-like receptor family contribute to the innate immune response of human epidermal keratinocytes Immunology 2005 114 4 531 541
35. Vernel-Pauillac F., Merien F., Proinflammatory and immunomodulatory cytokine mRNA time course profiles in hamsters infected with a virulent variant of Leptospira interrogans Infection and Immunity 2006 74 7 4172 4179
36. Girling J. E., Hedger M. P., Toll-like receptors in the gonads and reproductive tract: emerging roles in reproductive physiology and pathology Immunology and Cell Biology 2007 85 6 481 489
37. Ganz T., Immunology: versatile defensins Science 2002 298 5595 977 979
38. Ganz T., Defensins: antimicrobial peptides of innate immunity Nature Reviews Immunology 2003 3 9 710 720
39. Schröder N. W. J., Arditi M., The role of innate immunity in the pathogenesis of asthma: evidence for the involvement of Toll-like receptor signaling Journal of Endotoxin Research 2007 13 5 305 312
40. LeBouder E., Rey-Nores J. E., Rushmere N. K., Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk The Journal of Immunology 2003 171 12 6680 6689