Structural determinants of monohydroxylated bile acids to activate β1 subunit-containing BK channels

Journal of Lipid Research

Volumn 49, Issue 11, 2008, Pages 2441-2451

  Bukiya, Anna N ^a   McMilan, Jacob ^b   Parrill, Abby L ^b   Dopico, Alejandro M ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b University of Memphis   (United States)

Author keywords

Computational modeling; MaxiK channel; Protein ligand interaction; Steroids; Vascular smooth muscle; Vasodilation

Indexed keywords

5 CHOLENIC ACID 3BETA OL; ALLOLITHOCHOLIC ACID; BILE ACID; EPIALLOLITHOCHOLIC ACID; EPILITHOCHOLIC ACID; ION CHANNEL; LARGE CONDUCTANCE CALCIUM VOLTAGE GATED POTASSIUM CHANNEL BETA 1; LITHOCHOLATE SULFATE; LITHOCHOLIC ACID; LITHOCHOLIC ACID METHYL ESTER; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; KCNAB1 PROTEIN, RAT; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA SUBUNIT;

ANIMAL CELL; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; FEMALE; HYDROXYLATION; LIPID BILAYER; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; POLARIZATION; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; RAT; STEROID ANALYSIS; STEROID BINDING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; XENOPUS LAEVIS; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; GENE VECTOR; GENETICS; METABOLISM; PATCH CLAMP; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; VASCULAR SMOOTH MUSCLE;

ANIMALS; COMPUTER SIMULATION; FEMALE; GENETIC VECTORS; HYDROXYLATION; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL BETA SUBUNITS; LITHOCHOLIC ACID; MODELS, MOLECULAR; MUSCLE, SMOOTH, VASCULAR; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RATS; XENOPUS LAEVIS;

EID: 58149474714     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M800286-JLR200     Document Type: Article

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