Connexin40 messenger ribonucleic acid is positively regulated by thyroid hormone (TH) acting in cardiac atria via the TH receptor

Endocrinology

Volumn 150, Issue 1, 2009, Pages 546-

  Almeida, Norma A S ^a   Cordeiro, Aline ^a   Machado, Danielle S ^a   Souza, Luana L ^a   Ortiga Carvalho, Tǎnia M ^a   Campos de Carvalho, Antonio C ^a   Wondisford, Fredric E ^b   Pazos Moura, Carmen C ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 40; CONNEXIN 43; MESSENGER RNA; MYOSIN HEAVY CHAIN; PROTEIN; THYROID HORMONE; THYROID HORMONE RECEPTOR; THYROID HORMONE RECEPTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ELECTROCARDIOGRAM; HEART ATRIUM; HEART DEPOLARIZATION; HEART MUSCLE CELL; HYPERTHYROIDISM; HYPOTHYROIDISM; MOUSE; MUTANT; NONHUMAN; P WAVE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; UPREGULATION; WILD TYPE;

ANIMALS; CONNEXIN 43; CONNEXINS; DNA PRIMERS; ELECTROCARDIOGRAPHY; HEART ATRIA; MICE; MICE, MUTANT STRAINS; MYOSIN HEAVY CHAINS; PROTEIN C; RECEPTORS, THYROID HORMONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYROID HORMONES; TRIIODOTHYRONINE;

EID: 58149468050     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-0451     Document Type: Article

References (40)

1. Klein I, Ojamaa K 2001 Thyroid hormone and the cardiovascular system. NEngl J Med 334:501-509
2. Davis PJ, Davis FB 2002 Nongenornic actions of thyroid hormone on the heart. Thyroid 12:459-466
3. Gloss B, Trost SU, Bluhm WF, Swanson EA, Clark R, Winkfein R, Janzen KM, Giles W, Chassende O, Samarut J, Dillmann WH 2001 Cardiac ion channel expression and contractile function in mice with deletion of thyroid hormone receptor α or β. Endocrinology 142:544-550
4. Shimoni Y, Fiset C, Clark RB, Dixon JE, Mc Kinnon D, Giles WR 1997 Thyroid hormone regulates postnatal expression of transient K+ channel isoforms in rat ventricle. J Physiol 500(Pt 1):65-73
5. Le Bouter S, Demolombe S, Chambellan A, Bellocq C, Aimond F, Toumaniantz G, Lande G, Siavoshian S, Baró I, Pond A, Nerbonne JM, Léger JJ, Escande D, Charpentier F 2003 Microarray analysis reveals complex remodeling of cardiac ion channel expression with altered thyroid status. Circ Res 92:234-242
6. Watanabe H, Ma M, Washizuka T, Komura S, Yoshida T, hosaka Y, Hatada K, Chinushi M, Yamamoto T, Watanabe K, Aizawa Y 2003 Thyroid hormone regulates mRNA expression and currents of ion channels in rat atrium. Biochem Biophys Res Comrnum 308:439-444
7. Ma ML, Watanabe K, Watanabe H, Hosaka Y, Komura S, Aizawa Y, Yamamoto T 2003 Different gene expression of potassium channels by thyroid hormone and an antithyroid drug between the atrium and ventricle of rats. Jpn Heart J 44:101-110
8. Pazos-Moura CC, Abel ED, Boers ME, Moura E, Hampton TG, Wang J, Morgan JP, Wondisford FE 2000 Cardiac dysfunction caused by myocardiumspecific expression of a mutant thyroid hormone receptor, Circ Res 86:700-706
9. Usala SJ, Menke JB, Watson TL, Wondisford FE, Weintraub BD, Bérard J, Bradley WE, Ono S, Mueller OT, Bercu BB 1991 A homozygous deletion in the c-erbA β thyroid hormone receptor gene in a patient with generalized thyroid hormone resistance: isolation and characterization of the mutant receptor. Mol Endocrinol 5:327-335
10. + currents in left and right murine atria. Am J Physiol Heart Circ Physiol [Erratum (2006) 290:H489] 289:H1448-H1455
11. Sunagawa M, Yamakawa M, Shimabukuro M, Higa N, Takasu N, Kosugi T 2005 Electrophysiologic characteristics of atrial rnyocytes in levo-thyroxinetreated rats. Thyroid 15:3-11
12. Kumar NM, Gilula NB 1996 The gap junction communication channel. Cell 84:381-388
13. Hervé JC 2004 The connexins. Biochim Biophys Acta 1662:1-2
14. Gourdie RG, Green CR, Severs NJ 1991 Gap junction distribution in adult mammalian myocardium revealed by an anti-peptide antibody and laser scanning confocal microscopy. J Cell Sci 99(Pt 1):41-55
15. Delorme B, Dahl E, Jarry-Guichard T, Marics I, Briand JP, Willecke K, Gros D, Théveniau-Ruissy M 1995 Developmental regulation of connexin 40 gene expression in mouse heart correlates with the differentiation of the conduction system. Dev Dyn 204:358-371
16. Kirchhoff S, Nelles E, Hagendorff A, Kruger O, Traub O, Willecke K 1998 Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice. Curr Biol 8:299-302
17. Simon AM, Goodenough DA, Paul DL 1998 Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block. Curr Biol 8:295-298
18. Thomas SA, Schuessler RB, Berul CI, Beardslee MA, Beyer EC, Mendelsohn ME, Saffitz JE 1998 Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: evidence for chamber-specific molecular determinants of conduction. Circulation 97:686-691
19. Stock A, Sies H 2000 Thyroid hormone receptors bind to an element in the connexin43 promoter. Biol Chem 381:973-979
20. Tribulova N, Shneyvays V, Mamedova LK, Moshel S, Zinman T, Shainberg A, Manoach M, Weismann P, Kostin S 2004 Enhanced connexin-43 and α-sarcomeric actin expression in cultured heart myocytes exposed to triiodo-L- thyronine. J Mol Histol 35:463-470
21. Oliveira KJ, Ortiga-Carvalho TM, Cabanelas A, Veiga MA, Aoki K, Ohki- Hamazaki H, Wada K, Wada E, Pazos-Moura CC 2006 Disruption of neuromedin B receptor gene results in dysregulation of the pituitary-thyroid axis, J Mol Endocrinol 36:73-80
22. Pereira-Junior PP. Chaves EA, Costa-E-Sousa RH, Masuda MO, Carvalho AC, Nascimento JH 2006 Cardiac autonomic dysfunction in rats chronically treated with anabolic steroid. Eur J Appl Physiol 96:487-494
23. Swanson EA, Gloss B, Belke DD, Kaneshige M, Cheng S Y, Dillmann WH 2003 Cardiac expression and function of thyroid hormone receptor β and its PV mutant. Endocrinology 144:4820-4825
24. Stoykov I, Zandieh-Doulabi B, Moorman AF, Cliristoffels V, Wiersinga WM, Bakker O 2006 Expression pattern and ontogenesis of thyroid hormone receptor isoforms in the mouse heart. J Endocrinol 189:231-245
25. Hashimoto K, Curty FH, Borges PP, Lee CE, Abel ED, Elmquist JK, Cohen RN, Wondisford FE 2001 An unliganded thyroid hormone receptor causes severe neurological dysfunction. Proc Natl Acad Sci USA 98:3998-4003
26. Ortiga-Carvalho TM, Hashimoto K, Pazos-Moura CC, Geenen D, Cohen R, Land RM, Wondisford FE 2004 Thyroid hormone resistance in the heart: role of the thyroid hormone receptor β isoform. Endocrinology 145:1625-1633
27. Gustafson TA, Markham BE, Bahl JJ, Morkin E 1987 Thyroid hormone regulates expression of a transfected α-myosin heavy-chain fusion gene in fetal heart cells. Proc Natl Acad Sci USA 84:3122-3126
28. Buroker NE, Young ME, Wei C, Serikawa K, Ge M, Ning XH, Portman MA 2007 The dominant negative thyroid hormone receptor β-mutant 8337T alters PPARα signaling in heart. Am J Physiol Endocrinol Metab 292:E453-E460
29. Ojamaa K, Sabet A, Kenessey A, Shenoy R, Klein I 1999 Regulation of rat cardiac Kv1.5 gene expression by thyroid hormone is rapid and chamber specific. Endocrinology 140:3170-3176
30. Yamakawa M, Sunagawa M, Shimabukuro M, Higa N, Takasu N, Kosugi T 2005 Effect of sodium channel blocker, pilsicainide hydrochloride, on net inward current of atrial myocytes in thyroid hormone toxicosis rat. Thyroid 15:653-659
31. Dudley Jr SC, Baumgarten CM 1993 Bursting of cardiac sodium channels after acute exposure to 3,5,3'-triiodo-L-thyronine. Circ Res 73:301-313
32. 2+ in cat atrial myocytes. J Physiol 546(Pt 2):491-499
33. Hagendorff A, Schumacher B, Kirchhoff S, Lüderitz B, Willecke K 1999 Conduction disturbances and increased atrial vulnerability in Connexin40-deficient mice analyzed by transesophageal stimulation. Circulation 99:1508-1515
34. Bagwe S, Berenfeld O, Vaidya D, Morley GE, Jalife J 2005 Altered right atrial excitation and propagation in connexin40 knockout mice. Circulation 112:2245-2253
35. Levander-Lindgren M, Lantz B 1988 Bradyarrhythmia profile and associated diseases in 1,265 patients with cardiac pacing. Pacing Clin Electrophysiol 11:2207-2215
36. Mangiardi L, Gaita F, Brun S, Presbitero P, Nademanee K, Singh BN 1986 Atrioventricular block complicating amiodarone-induced hypothyroidism in a patient with pre-excitation and rate-dependent bilateral bundle branch block. J Am Coll Cardiol 7:180-184
37. Klein I, Ojamaa K 2000 The cardiovascular system in hypothyroidism. In: Braverman LE, Utiger RD, eds. Werner & Ingbar's the thyroid: a fundamental and clinical text. 8th ed. Philadelphia: Lippincott Williams & Wilkins; 777-782
38. Dupont E, Ko Y, Rothery S, Coppen SR, Baghai M, Haw M, Severs NJ 2001 The gap-junctional protein connexin40 is elevated in patients susceptible to postoperative atrial fibrillation. Circulation 103:842-849
39. Firouzi M, Ramanna H, Kok B, Jongsma HJ, Koeleman BP, Doevendans PA, Groenewegen WA, Hauer RN 2004 Association of human connexin40 gene polymorphisms with atrial vulnerability as a risk factor for idiopathic atrial fibrillation. Circ Res 95:e29-e33
40. Wetzel U, Boldt A, Lauschke J, Weigl J, Schirdewahn P, Dorszewski A, Doll N, Hindricks G, Dhein S, Kottkamp H 2005 Expression of connexins 40 and 43 in human left atrium in atrial fibrillation of different aetiologies. Heart 91:166-170