Type 1 cannabinoid receptor-containing axons innervate hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons

Endocrinology

Volumn 150, Issue 1, 2009, Pages 98-103

  Deli, Levente ^a   Wittmann, Gábor ^a   Kalló, Imre ^a   Lechan, Ronald M ^b,c   Watanabe, Masahiko ^d   Liposits, Zsolt ^a,e   Fekete, Csaba ^a,b  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b TUFTS MEDICAL CENTER   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HOKKAIDO UNIVERSITY   (Japan)

^e PÁZMÁNY PÉTER CATHOLIC UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISERUM; CANNABINOID 1 RECEPTOR; ENDOCANNABINOID; PROTIRELIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIVISION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DENDRITE; HYPOPHYSIS; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INNERVATION; MALE; MOUSE; NERVE CELL; NERVE FIBER; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; REGULATORY MECHANISM; SYNAPSE; THALAMUS MIDLINE NUCLEUS;

ANIMALS; AXONS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED STRAINS; MICROSCOPY, ELECTRON; NEURONS; RECEPTOR, CANNABINOID, CB1; SYNAPSES; THYROTROPIN-RELEASING HORMONE;

EID: 58149466995     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-0330     Document Type: Article

References (26)

1. Fekete C, Lechan RM 2007 Negative feed back regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: role of neuronal afferents and type 2 deiodinase. Front Neuroendocrinol 28:97-114
2. Silva JE 2003 The thermogenic effect of thyroid hormone and its clinical implications. Ann Intern Med 139:205-213
3. Lechan RM, Fekete C 2006 The TRH neuron: a hypothalamic integrator of energy metabolism. Prog Brain Res 153:209-235
4. Piomelli D 2003 The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 4:873-884
5. Freund TF, Katona I, Piomelli D 2003 Role of endogenous cannabinoids in synaptic signaling. Physiol Rev 83:1017-1066
6. Fagotto U, Marsicano G, Cota D, Lutz B, Pasquali R 2006 The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr Rev 27:73-100
7. Kirkham TC, Williams CM, Fezza F, Di Marzo V 2002 Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. Br J Pharmacol 136:550-557
8. Cota D, Marsicano G, Tschop M, Grubler Y, Flachskamm C, Schubert M, Auer D, Yassouridis A, Thone-Reineke C, Ortmann S, Tomassoni F, Cervino C, Nisoli E, Linthorst AC, Pasquali R, Lutz B, Stalla GK, Pagotto U 2003 The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest 112:423-431
9. Di Marzo V, Goparaju SK, Wang L, Liu J, Batkai S, Jarai Z, Fezza F, Miura GI, Palmiter RD, Sugiura T, Kunos G 2001 Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 410:822-825
10. Wittmann G, Deli L, Kallo I, Hrabovszky E, Watanabe M, Liposits Z, Fekete C 2007 Distribution of type 1 cannabinoid receptor (CB1)-immunoreactive axons in the mouse hypothalamus. J Comp Neurol 503:270-279
11. Hillard CJ, Farber NE, Hagen TC, Bloom AS 1984 The effects of Δ9-tetrahydrocannabinol on serum thyrotropin levels in the rat. Pharmacol Biochem Behav 20:547-550
12. Di S, Malcher-Lopes R, Halmos KC, Tasker JG 2003 Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism. J Neurosci 23:4850-4857
13. Fukudome Y, Ohno-Shosaku T, Matsui M, Omori Y, Fukaya M, Tsubokawa H, Taketo MM, Watanabe M, Manabe T, Kano M 2004 Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling. Eur J Neurosci 19:2682-2692
14. Liposits Z, Setalo G, Flerko B 1984 Application of the silver-gold intensified 3,3'-diaminobenzidine chromogen to the light and electron microscopic detection of the luteinizing hormone-releasing hormone system of the rat brain. Neuroscience 13:513-525
15. Lechan RM, Jackson IM 1982 Immunohistochemical localization of thyrotropin-releasing hormone in the rat hypothalamus and pituitary. Endocrinology 111:55-65
16. Makara JK, Katona I, Nyiri G, Nemeth B, Ledent C, Watanabe M, de Vente J, Freund TF, Hajos N 2007 Involvement of nitric oxide in depolarizationinduced suppression of inhibition in hippocampal pyramidal cells during activation of cholinergic receptors. J Neurosci 27:10211-10222
17. Fekete C, Mihaly E, Luo LG, Kelly J, Clausen JT, Mao Q, Rand WM, Moss LG, Kuhar M, Emerson CH, Jackson IM, Lechan RM 2000 Association of cocaine - and amphetamine-regulated transcript-immunoreactive elements with thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and its role in the regulation of the hypothalamicpituitary-thyroid axis during fasting. J Neurosci 20:9224-9234
18. Gray EG 1959 Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. J Anat 93:420-433
19. Jo YH, Chen YJ, Chua Jr SC, Talmage DA, Role LW 2005 Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit. Neuron 48:1055-1066
20. Kola B, Farkas I, Christ-Grain M, Wittmann G, Lolli F, Amin F, Ajodha S, Harvey-White J, Liposits Z, Kunos G, Grossman AB, Fekete C, Korbonits M 2008 The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. Plos One e1797
21. Peters A, Palay SL, Webster H 1991 The fine structure of the nervous system. Neurons and their supporting cells. 3rd ed. Oxford, UK: Oxford University Press
22. Katona I, Sperlagh B, Sik A, Kafalvi A, Vizi ES, Mackie K, Freund TF 1999 Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons. J Neurosci 19: 4544-4558
23. Katona I, Urban GM, Wallace M, Ledent C, Jung KM, Piomelli D, Mackie K, Freund TF 2006 Molecular composition of the endocannabinoid system at glutamatergic synapses. J Neurosci 26:5628-5637
24. Tschop M, Smiley DL, Heiman ML 2000 Ghrelin induces adiposity in rodents. Nature 407:908-913
25. 2+ entry in the rat cerebral cortex nerve terminals: suppression of this inhibitory effect by the protein kinase C-dependent facilitatory pathway. Neuroscience 134: 987-1000
26. Rettori V, Fernandez-Solari J, Prestifilippo JP, Mohn C, De Laurentiis A, Bornstein SR, Ehrhart-Bornstein M, Elverdin JC, McCann SM 2007 Endocannabinoids in TNF-α and ethanol actions. Neuroimmunomodulation 14: 188-192