NMDAR blockade-induced neonatal brain injury: Reversal by the calcium channel agonist BayK 8644

Neuroscience Letters

Volumn 450, Issue 3, 2009, Pages 292-295

  Turner, Christopher P ^a   DeBenedetto, Danielle ^a   Liu, Chun ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Dizocilpine; MK801; Postnatal; Rat; Set point hypothesis

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; ANESTHETIC AGENT; CALCIUM; CALCIUM CHANNEL STIMULATING AGENT; DIZOCILPINE; DRUG VEHICLE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INJURY; BRAIN REGION; CALCIUM BINDING; CALCIUM CELL LEVEL; CAUDATE NUCLEUS; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABUSE; NERVE CELL; NEUROTOXICITY; NEWBORN; NEWBORN DISEASE; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PUTAMEN; RAT; RETROSPLENIAL CORTEX; SOMATOSENSORY CORTEX;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BRAIN; BRAIN DAMAGE, CHRONIC; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNELS; CALCIUM SIGNALING; DISEASE MODELS, ANIMAL; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; NEOSTRIATUM; NERVE DEGENERATION; NEURONS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SOMATOSENSORY CORTEX;

EID: 58149462761     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.12.002     Document Type: Article

References (15)

1. Dzietko M., Felderhoff-Mueser U., Sifringer M., Krutz B., Bittigau P., Thor F., Heumann R., Buhrer C., Ikonomidou C., and Hansen H.H. Erythropoietin protects the developing brain against N-methyl-d-aspartate receptor antagonist neurotoxicity. Neurobiol. Dis. 15 (2004) 177-187
2. Ikonomidou C., Bosch F., Miksa M., Bittigau P., Vockler J., Dikranian K., Tenkova T.I., Stefovska V., Turski L., and Olney J.W. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 283 (1999) 70-74
3. Johnson Jr. E.M., Koike T., and Franklin J. A "calcium set-point hypothesis" of neuronal dependence on neurotrophic factor. Exp. Neurol. 115 (1992) 163-166
4. Lei G., Xia Y., and Johnson K.M. The role of Akt-GSK-3beta signaling and synaptic strength in phencyclidine-induced neurodegeneration. Neuropsychopharmacology 33 (2008) 1343-1353
5. Lema Tomé C.M., Bauer C., Nottingham C., Smith C., Blackstone K., Brown L., Hlavaty C., Nelson C., Daker R., Sola R., Miller R., Bryan R., and Turner C.P. MK801-induced caspase-3 in the postnatal brain: inverse relationship with calcium binding proteins. Neuroscience 141 (2006) 1351-1363
6. Lema Tomé C.M., Miller R., Bauer C., Nottingham C., Smith C., Blackstone K., Brown L., Bryan R., Leigh A., Brady M., Busch J., and Turner C.P. Decline in age-dependent, MK801-induced injury coincides with developmental switch in parvalbumin expression: cingulate and retrosplenial cortex. Dev. Psychobiol. 49 (2007) 606-618
7. Lema Tomé C.M., Miller R., Bauer C., Smith C., Blackstone K., Leigh A., Busch J., and Turner C.P. Decline in age-dependent, MK801-induced injury coincides with developmental switch in parvalbumin expression: somatosensory and motor cortex. Dev. Psychobiol. (2008)
8. Lema Tomé C.M., Nottingham C.U., Smith C.M., Beauchamp A.S., Leung P.W., and Turner C.P. Neonatal exposure to MK801 induces structural reorganization of the central nervous system. Neuroreport 17 (2006) 779-783
9. Lu L.X., Yon J.H., Carter L.B., and Jevtovic-Todorovic V. General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain. Apoptosis 11 (2006) 1603-1615
10. Turner C.P., Connell J., Blackstone K., and Ringler S.L. Loss of calcium and increased apoptosis within the same neuron. Brain Res. 1128 (2007) 50-60
11. Turner C.P., Miller R., Smith C., Brown L., Blackstone K., Dunham S.R., Strehlow R., Manfredi M., Slocum P., Iverson K., West M., Ringler S.L., and Berry Z.C. Widespread neonatal brain damage following calcium channel blockade. Dev. Neurosci. 29 (2007) 213-231
12. Turner C.P., Pulciani D., and Rivkees S.A. Reduction in intracellular calcium levels induces injury in developing neurons. Exp. Neurol. 178 (2002) 21-32
13. Wang C., Anastasio N., Popov V., Leday A., and Johnson K.M. Blockade of N-methyl-d-aspartate receptors by phencyclidine causes the loss of corticostriatal neurons. Neuroscience 125 (2004) 473-483
14. Wang C., Showalter V.M., Hillman G.R., and Johnson K.M. Chronic phencyclidine increases NMDA receptor NR1 subunit mRNA in rat forebrain. J. Neurosci. Res. 55 (1999) 762-769
15. Wang C.Z., Yang S.F., Xia Y., and Johnson K.M. Postnatal phencyclidine administration selectively reduces adult cortical parvalbumin-containing interneurons. Neuropsychopharmacology 33 (2008) 2442-2455