Genotoxicity and cytotoxicity in multiple organs induced by titanium miniplates in Wistar rats

Journal of Biomedical Materials Research - Part A

Volumn 88, Issue 2, 2009, Pages 342-347

  Piozzi, Rodrigo ^a   Ribeiro, Daniel Araki ^b   Padovan, Luís Eduardo Marques ^a   Nary Filho, Hugo ^a   Matsumoto, Mariza Akemi ^a  

^a UNIVERSIDADE DO SAGRADO CORAÇÃO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cytoxicity; Genotoxicity; Rat; Titanium

Indexed keywords

CORROSION PHENOMENONS; CYTOXICITY; DNA DAMAGES; DNA DAMAGING; EXPERIMENTAL DESIGNS; EXPERIMENTAL GROUPS; GENOTOXICITY; HISTOPATHOLOGICAL ANALYSES; HUMAN BODIES; HUMAN HEALTHS; IN-VIVO; METAL RELEASES; METALLIC BIOMATERIALS; MORPHOLOGICAL ALTERATIONS; NEGATIVE CONTROLS; RANDOMLY DISTRIBUTED; SINGLE CELLS; WISTAR RATS;

ANIMALS; BIOLOGICAL MATERIALS; BIOLOGICAL ORGANS; BIOMATERIALS; COLLOIDS; DNA; EXPERIMENTS; FIXTURES (TOOLING); GELATION; GENES; LIVER; NUCLEIC ACIDS; ORGANIC ACIDS; RATS; TITANIUM;

TITANIUM ALLOYS;

TITANIUM;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE PLATE; COMET ASSAY; COMPOSITE MATERIAL; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; EXPERIMENTAL MODEL; GENOTOXICITY; HISTOPATHOLOGY; IMPLANTATION; KIDNEY; LIVER; LUNG; MALE; MORPHOLOGY; NONHUMAN; PLATE FIXATION; RAT; STAIN; TIBIA; WISTAR RAT;

ANIMALS; BIOCOMPATIBLE MATERIALS; COMET ASSAY; CYTOTOXINS; DNA DAMAGE; HUMANS; IMPLANTS, EXPERIMENTAL; KIDNEY; LIVER; LUNG; MALE; MATERIALS TESTING; MUTAGENICITY TESTS; MUTAGENS; RANDOM ALLOCATION; RATS; RATS, WISTAR; TITANIUM;

EID: 58149387581     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.31876     Document Type: Article

References (36)

1. Sugimura T, Terada M, Yokota J, Hirohashi S, Wakabayashi K. Multiple genetic alterations in human carcinogenesis. Environ Health Perspect 1992;98:5-12.
2. Sarasin A. An overview of the mechanisms of mutagenesis and carcinogenesis. Mutat Res 2003;544:99-106.
3. Ribeiro DA, Marques MEA, Salvadori DMF. Assessment of genetic damage induced by dental bleaching agents on mouse lymphoma cells by single cell gel (comet) assay. J Oral Rehabil 2005;32:766-771.
4. Leventhal GS Titanium,a metal for surgery. J Bone Joint Surg A 1951;33:473.
5. Breine U, Branemark PI. Reconstruction of alveolar jaw bone. Scand J Plast Surg 1980;14:14-18.
6. Meachim G, Willians DF. Changes in non-osseous tissue adjacent to titanium implants. J Biomed Mater Res 1973;7:555-572.
7. Woodman JL, Jacobs JJ, Galante JO, Urban RM. Metal ion release from titanium-based prosthetic segmental replacements of long bones in baboons: A long-term study. J Orthop Res 1984;1:421-430.
8. Orborn JF, Willich P, Meenen N. The release of titanium into human bone from a titanium implant coated with plasma-sprayed titanium. In: Heimke G, Soltesz U, Lee AJC, editors. Advances in Biomaterials. Amsterdam Elsevier, 1990. p 75-80.
9. Jorgenson DS, Mayer MH, Ellenbogen RG, Centeno JA, Johnson FB, Mullick FG, Manson PN. Detection of titanium in human tissues after craniofacial surgery. Plast Reconstr Surg 1997;99:976-979.
10. Acero J, Calderon J, Salmeron JI. The behavior of titanium as a biomaterial: Microscopy study of plates and surrounding tissues in facial osteosynthesis. J Craniomaxillofac Surg 1999;27:117-123.
11. Auletta A, Ashby J. Workshop on the relationship between short-term information and carcinogenicity; Williamsburg. Virginia, January 20-23, 1987. Environ Mol Mutagen 1988;11:135-145.
12. Bull S, Fletcher K, Boobis AR, Battershill JM. Evidence for genotoxicity of pesticides in pesticide applicators: A review. Mutagenesis 2006;21:93-103.
13. Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu JC, Sasaki YF. Single cell gel/comet assay. Environ Mol Mutagen 2000;35:206-221.
14. Olive PL, Banath JP, Durand RE. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the comet assay. Radiat Res 1990;112:86-94.
15. Ribeiro DA, Bazo AP, Franchi CAS, Marques MEA, Salvadori DMF. Chlorhexidine induces DNA damage in rat peripheral leukocytes and oral mucosal cells. J Periodont Res 2004;39:358-361.
16. Ribeiro DA, Scolastici C, de Lima PLA, Marques MEA, Salvadori DMF. Genotoxicity of antimicrobial endodontic compounds by single cell gel (comet) assay in Chinese hamster ovary (CHO) cells. Oral Surg Oral Oral Med Oral Pathol Oral Radiol Endod 2005;99:637-640.
17. Braz MG, Camargo EA, Salvadori DM, Marques ME, Ribeiro DA. Evaluation of genetic damage in human peripheral lymphocytes exposed to mineral trioxide aggregate and Portland cements. J Oral Rehabil 2006;33:234-239.
18. Grassi TF, Camargo EA, Salvadori DM, Marques ME, Ribeiro DA. DNA damage in multiple organs after exposure to chlorhexidine in multiple organs. Int J Hyg Environ Health 2007;210:163-167.
19. Matthew IR, Frame JW, Browne RM, Millar BG. In vivo surface analysis of titanium and stainless steel miniplates and screws. Int J Oral Maxillofac Surg 1996;25:463-468.
20. Buzalaf MA, Salvadori DM, Marques ME, Caroselli EE, Leite AL, Camargo EA, Ribeiro DA. Absence of DNA damage in multiple organs after oral exposure to fluoride in Wistar rats. Bull Environ Contam Toxicol 2006;77:700-706.
21. Hartmann A, Agurell E, Beevers C, Brendler-Schwaab S, Burlinson B, Clay P, Collins A, Smith A, Speit G, Thybaud V, Tice RR. Recommendations for conducting the in vivo alkaline comet assay. Mutagenesis 2003;18:45-51.
22. Singh NP, McCoy MT, Tice RR, Schneider EI. [title] A simple technique for quantification of low levels of DNA damage in individual cells. Exp Cell Res 1988;175:184-191.
23. Eisenbrand G, Pool-Zobel BL, Baker M, Balls BJ, Blaauboer AR, Boobis A, Carere S, Kevekordes JC, Lhuguenot R, Pieters J, Kleiner J. Methods in vitro toxicology. Food Chem Toxicol 2002;40:193-236.
24. Ribeiro DA, Pereira PC, Machado JM, Silva SB, Pessoa AW, Salvadori DM. Does toxoplasmosis cause DNA damage? An evaluation in isogenic mice under normal diet or dietary restriction. Mutat Res 2004;559:169-176.
25. Bessho K, Fujimura K, Iziuka T. Experimental long-term study of titanium ions eluted from pure titanium miniplates. J Biomed Mater Res 1995;29:901-904.
26. Schiephake H, Reiss G, Urban R. Metal release from titanium fixtures during placement in the mandible: An experimental study. Int J Oral Maxillofac Implants 1993;8:502-511.
27. Cotran RS, Kumar V, Collins V. Robbins. Patologia Estrutural e Funcional, 6th ed, Philadelphia: Guanabara Koogan; 2000 (Portuguese).
28. Redline S, Barna B, Tomashefski JF Jr, Abraham IL. Granulomatous disease associated with pulmonary deposition of titanium. Brit J Ind Med 1986;43:652-656.
29. Moran CA, Mullick FG, Ishak KG, Johnson FB, Hummer WB. Identification of titanium in human tissues: Probable role in pathologic processes. Human Pathol 1991;22:450-454.
30. Dote E, Dote T, Shimizu H, Shimbo Y, Fujihara M, Kono K. Acute lethal toxicity, hyperkalemia associated with renal injury and hepatic damage after intravenous administration of cadmium nitrate in rats. J Occup Health 2007;49:17-24.
31. Ribeiro DA, Matsumoto MA, Padovan LE, Marques ME, Salvadori DM. Genotoxicity of corrosion eluates obtained from endosseous implants. Implant Dent 2007;16:101-109.
32. Speit G, Merck O. Detection of crosslinks with the comet assay in relationship to genotoxicity and cytotoxicity. Environ Mol Mutagen 1999;33:167-72.
33. Harwing A. Current aspects in metal genotoxicity. Biometals 1995;8:3-11.
34. Fracasso ME, Perbellini L, Solda S. Lead induced DNA strand breaks in lymphocytes of exposed workers: Role of reactive oxygen species and protein kinase C. Mutat Res 2002;515:159-169.
35. Rocha MEM, Ferreira AMDC, Bechara EJH. Roles of phosphate and an enoyl radical in ferritin iron mobilization by 5-aminolevulinic acid. Free Radic Biol Med 2000;29:1272-1279.
36. Sasaki YF, Kawaguchi S, Kamaya A, Ohshita M, Kabasawa K, Iwama K, Taniguchi K, Tsuda S. The comet assay with 8 mouse organs: Results with 39 currently used food additives. Mutat Res 2002;519:103-119.