Acute lethal toxicity, hyperkalemia associated with renal injury and hepatic damage after intravenous administration of cadmium nitrate in rats

Journal of Occupational Health

Volumn 49, Issue 1, 2007, Pages 17-24

  Dote, Emi ^a   Dote, Tomotaro ^a   Shimizu, Hiroyasu ^a   Shimbo, Yukari ^a   Fujihara, Michiko ^a   Kono, Koichi ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Cadmium nitrate; Glomerular dysfunction; Hyperkalemia; Proximal tubular injury

Indexed keywords

CADMIUM DERIVATIVE; CADMIUM NITRATE; NITRATE; UNCLASSIFIED DRUG;

ACUTE KIDNEY FAILURE; ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG DETOXIFICATION; GLOMERULUS; HYPERKALEMIA; INJURY; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY PROXIMAL TUBULE; LD 50; LIVER DISEASE; MALE; PATHOPHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; CADMIUM COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERKALEMIA; INFUSIONS, INTRAVENOUS; KIDNEY FAILURE, ACUTE; KIDNEY GLOMERULUS; KIDNEY TUBULES, PROXIMAL; LETHAL DOSE 50; LIVER DISEASES; MALE; METABOLIC DETOXICATION, DRUG; NITRATES; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 33847611574     PISSN: 13419145     EISSN: 13489585     Source Type: Journal    
DOI: 10.1539/joh.49.17     Document Type: Article

References (25)

1. Yates EM. The world needs cadmium - a miner's viewpoint. In: Cook ME, eds. Cadmium 92. London : Cadmium Association, 1992: 1-7.
2. U.S. Geological Survey. Mineral commodity summaries, January 2005. (online), available from 〈http://minerals.vsgs.gov/minerals/pubs/commodity/ cadmium/〉, (accessed 2006-01-10).
3. Morrow H. Cadmium markets and trends, September 2005. New Zealand: International Cadmium Association.
4. Mallinckrodt Baker, Inc. Material Safety Data Sheet. U.S.A.: Environmental Health and Safety, 2000.
5. International Programme on Chemical Safety. Environmental Health Criteria. Cadmium. No. 134. Switzerland, 1992.
6. Hoffmann EO, Cook JA, di Luzio NR and Coover JA: The effects of acute cadmium administration in the liver and kidney of the rat. Light and electron microscopic studies. Laboratory Investigation; A Journal of Technical Methods and Pathology 32, 655-664 (1975)
7. Hirano S, Tsukamoto N and Suzuki KT: Biochemical changes in the rat lung and liver following intratracheal instillation of cadmium oxide. Toxicol Lett 50, 97-105 (1990)
8. Curtis DK. In: Klaassen CD, ed. Casarett & Doull's toxicology: The basic science of poisons 6th ed. New York: McGraw-Hill Professional, 2001: 27.
9. National Library of Medicene: Chemical Dplus Lite Record. Evaluation of the impact of cadmium on the health of man, Vol. 1. Oxford: Pergamon Press, 1978: 67. (online), available from 〈http://chem.sis.nlm.nih.gov/chemidplus/ jsp/common/Toxicity.jsp?calledFrom=lite〉, (accessed 2005-12-19).
10. Kotsonis FN and Klaassen CD: Toxicity and distribution of cadmium administered to rats at sublethal doses. Toxicol Appl Pharmacolol 41, 667-680 (1977)
11. Obersdoerster G, Baumert HP, Hochrainer D and Stoeber W: The clearance of cadmium aerosols after inhalation exposure. Am Ind Hyg Assoc J 40, 443 (1979)
12. Klimisch HJ: Lung deposition, lung clearance and renal accumulation of inhaled cadmium chloride and cadmium sulphide in rat. Toxicology 84, 103-124 (1993)
13. Dudley RE, Svoboda DJ and Klaassen C: Acute exposure to cadmium causes severe liver injury in rats. Toxicol Appl Pharmacol 65, 302-313 (1982)
14. Tzirogiannis KN, Panoutsopoulos GI, Demonakou MD, Hereti RI, Alexandropoulou KN, Basayannis AC and Mykoniatis MG: Time-course of cadmium-induced acute hepatotoxicity in the rat liver: the role of apoptosis. Arch Toxicol 77, 694-701 (2003)
15. Numakami K, Aoki Y, Ogawa Z and Itoh H: A kinetic model of mitochondrial asparate aminotransferase transmigration in hepatobiliary disorders. Ann Clin Biochem 36, 226-232 (1999)
16. Rikans LE and Yamano T: Mechanisms of cadmium-mediated acute hepatotoxicity. J Biochem Mol Toxicol 14, 110-117 (2000)
17. Dudley RE, Gammal LM and Klaassen CD: Cadmium-induced hepatic and renal injury in chronically exposed rats: likely role of hepatic cadmium- metallothionein in nephrotoxicity. Toxicol Appl Pharmacol 77, 414-426 (1985)
18. Goyer RA: Mechanisms of lead and cadmium nephrotoxicity. Toxicol Lett 46, 153-162 (1989)
19. Jarup L, Berglund M, Elinder CG, Nordberg G and Vahter M: Health effects of cadmium exposure- review of the literature and a risk estimate. Scand J Work Environ Health 24 (Suppl 1), 1-51 (1998)
20. Hoffmann EO, Cook JA, di Luzio NR and Coover JA: The effects of acute cadmium administration in the liver and kidney of the rat. Light and electron microscopic studies. Lab Invest 32, 655-664 (1975)
21. Cherian MG, Goyer RA and Delaquerriere-Richardson L: Cadmium- metallothionein-induced nephropathy. Toxicol Appl Pharmacol 38, 399-408 (1976)
22. Kara H, Karatas F, Canatan H and Servi K: Effects of exogenous metallothionein on acute cadmium toxicity in rats. Biol Trace Elem Res 104, 223-232 (2005)
23. Bergamaschi E, Mutti A, Bocchi MC, Alinovi R, Olivetti G, Ghiggeri GM and Franchini I: Rat model of perchloroethylene-induced renal dysfunctions. Environ Res 59, 427-439 (1992)
24. Wrenn KD, Slovis CM and Slovis BS: The ability of physicians to predict hyperkalemia from ECG. Ann Emerg Med 20, 1229-1232 (1991)
25. Reham S and Michael PW: Acute Cadmium chloride-induced renal toxicity in syrian hamster. Toxicol Appl Pharmacol 104, 94-105 (1990)