Synthesis of orthogonally protected optically pure ketopiperazine, diketopiperazine, ketodiazepane, and 3-aminopyrrolidone building blocks for peptidomimetic combinatorial chemistry

Tetrahedron

Volumn 65, Issue 7, 2009, Pages 1389-1396

  Gellerman, Gary ^a   Hazan, Eran ^a,b   Kovaliov, Marina ^a,b   Albeck, Amnon ^b   Shatzmiler, Shimon ^a  

^a ARIEL UNIVERSITY   (Israel)

^b BAR ILAN UNIVERSITY   (Israel)

Author keywords

'Around the scaffold' drug optimization; Boc Fmoc strategy; Orthogonal protection; Reductive alkylation; Solid Phase Organic Chemistry (SPOC)

Indexed keywords

2 PYRROLIDONE DERIVATIVE; AMINO ACID; DIAZEPINE DERIVATIVE; DIPEPTIDE; PEPTIDOMIMETIC AGENT; PIPERAZINE DERIVATIVE;

ALKYLATION; ARTICLE; CHIRALITY; COMBINATORIAL CHEMISTRY; DRUG DESIGN; DRUG SYNTHESIS; PRIORITY JOURNAL; REDUCTION KINETICS; RING OPENING; STEREOCHEMISTRY;

EID: 58149356951     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2008.12.046     Document Type: Article

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