Functional importance of evolutionally conserced Tbx6 binding sites in the presomitic mesoderm-specific enhancer of Mesp2

Development

Volumn 135, Issue 21, 2008, Pages 3511-3519

  Yasuhiko, Yukuto ^a   Kitajima, Satoshi ^a   Takahashi, Yu ^a   Oginuma, Masayuki ^b   Kagiwada, Harumi ^c   Kanno, Jun ^a   Saga, Yumiko ^b  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b NATIONAL INSTITUTE OF GENETICS   (Japan)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Enhancer; Somitogenesis; T box transciption factor; Targeted disruption

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR MESP2; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TBX6; UNCLASSIFIED DRUG; MESP2 PROTEIN, MOUSE; NOTCH RECEPTOR; TBX6 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENHANCER REGION; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENETIC CONSERVATION; MESODERM; MOLECULAR EVOLUTION; MOUSE; MYOPATHY; NONHUMAN; ORYZIAS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; ANIMAL; ANIMAL EMBRYO; ANTIBODY SPECIFICITY; BIOLOGICAL MODEL; GENE TARGETING; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PRENATAL DEVELOPMENT; SIGNAL TRANSDUCTION; SOMITE;

MUS; ORYZIINAE;

ANIMALS; BASE SEQUENCE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BINDING SITES; CONSERVED SEQUENCE; EMBRYO, MAMMALIAN; ENHANCER ELEMENTS, GENETIC; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; MESODERM; MICE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; ORGAN SPECIFICITY; ORYZIAS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; SOMITES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 58149343855     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.027144     Document Type: Article

References (31)

1. Bussen, M., Petry, M., Schuster-Gossler, K., Leitges, M., Gossler, A. and Kispert, A. (2004). The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Genes Dev. 18, 1209-1221.
2. Chapman, D. L. and Papaioannou, V. E. (1998). Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature 391, 695-697.
3. Chapman, D. L., Agulnik, I., Hancock, S., Silver, L. M. and Papaioannou, V. E. (1996). Tbx6, a mouse T-Box gene implicated in paraxial mesoderm formation at gastrulation. Dev. Biol. 180, 534-542.
4. Delfini, M. C., Dubrulle, J., Malapert, P., Chal, J. and Pourquie, O. (2005). Control of the segmentation process by graded MAPK/ERK activation in the chick embryo. Proc. Natl. Acad. Sci. USA 102, 11343-11348.
5. Dunty, W. C., Jr, Biris, K. K., Chalamalasetty, R. B., Taketo, M. M., Lewandoski, M. and Yamaguchi, T. P. (2008). Wnt3a/β-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation. Development 135, 85-94.
6. Galceran, J., Sustmann, C., Hsu, S. C., Folberth, S. and Grosschedl, R. (2004). LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev. 18, 2718-2723.
7. Haraguchi, S., Kitajima, S., Takagi, A., Takeda, H., Inoue, T. and Saga, Y. (2001). Transcriptional regulation of Mesp1 and Mesp2 genes: differential usage of enhancers during development. Mech. Dev. 108, 59-69.
8. Hitachi, K., Kondow, A., Danno, H., Inui, M., Uchiyama, H. and Asashima, M. (2008). Tbx6, Thylacine1, and E47 synergistically activate bowline expression in Xenopus somitogenesis. Dev. Biol. 313, 816-828.
9. Hofmann, M., Schuster-Gossler, K., Watabe-Rudolph, M., Aulehla, A., Herrmann, B. G. and Gossler, A. (2004). WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos. Genes Dev. 18, 2712-2717.
10. Hogan, B., Beddington, R., Costantini, F. and Lacy, E. (1994). Manipulating the Mouse Embryo: a Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
11. Moreno, T. A. and Kintner, C. (2004). Regulation of segmental patterning by retinoic acid signaling during Xenopus somitogenesis. Dev. Cell 6, 205-218.
12. Morimoto, M., Takahashi, Y., Endo, M. and Saga, Y. (2005). The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. Nature 435, 354-359.
13. Morimoto, M., Kiso, M., Sasaki, N. and Saga, Y. (2006). Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis. Dev. Biol. 300, 687-698.
14. Nikaido, M., Kawakami, A., Sawada, A., Furutani-Seiki, M., Takeda, H. and Araki, K. (2002). Tbx24, encoding a T-box protein, is mutated in the zebrafish somite-segmentation mutant fused somites. Nat. Genet. 31, 195-199.
15. Nomura-Kitabayashi, A., Takahashi, Y., Kitajima, S., Inoue, T., Takeda, H. and Saga, Y. (2002). Hypomorphic Mesp allele distinguishes establishment of rostrocaudal polarity and segment border formation in somitogenesis. Development 129, 2473-2481.
16. Oginuma, M., Niwa, Y., Chapman, D. L. and Saga, Y. (2008). Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis. Development 35, 2555-2562.
17. Rupp, R. A., Snider, L. and Weintraub, H. (1994). Xenopus embryos regulate the nuclear localization of XMyoD. Genes Dev. 8, 1311-1323.
18. Saga, Y. and Takeda, H. (2001). The making of the somite: molecular events in vertebrate segmentation. Nat. Rev. Genet. 2, 835-845.
19. Saga, Y., Yagi, T., Ikawa, Y., Sakakura, T. and Aizawa, S. (1992). Mice develop normally without tenascin. Genes Dev. 6, 1821-1831.
20. Saga, Y., Hata, N., Koseki, H. and Taketo, M. M. (1997). Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes Dev. 11, 1827-1839.
21. Sasaki, H. and Hogan, B. L. (1996). Enhancer analysis of the mouse HNF-3 beta gene: regulatory elements for node/notochord and floor plate are independent and consist of multiple sub-elements. Genes Cells 1, 59-72.
22. Sawada, A., Fritz, A., Jiang, Y. J., Yamamoto, A., Yamasu, K., Kuroiwa, A., Saga, Y. and Takeda, H. (2000). Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites. Development 127, 1691-1702.
23. Takahashi, Y., Koizumi, K., Takagi, A., Kitajima, S., Inoue, T., Koseki, H. and Saga, Y. (2000). Mesp2 initiates somite segmentation through the Notch signalling pathway. Nat. Genet. 25, 390-396.
24. Takahashi, Y., Inoue, T., Gossler, A. and Saga, Y. (2003). Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites. Development 130, 4259-4268.
25. Takahashi, Y., Yasuhiko, Y., Kitajima, S., Kanno, J. and Saga, Y. (2007). Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation. Dev. Biol. 304. 593-603.
26. Terasaki, H., Murakami, R., Yasuhiko, Y., Shin, I. T., Kohara, Y., Saga, Y. and Takeda, H. (2006). Transgenic analysis of the medaka mesp-b enhancer in somitogenesis. Dev. Growth Differ. 48, 153-168.
27. van Eeden, F. J., Granato, M., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C. P., Jiang, Y. J., Kane, D. A. et al. (1996). Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. Development 123, 153-164.
28. White, P. H. and Chapman, D. L. (2005). Dll1 is a downstream target of Tbx6 in the paraxial mesoderm. Genesis 42, 193-202.
29. Wittler, L., Shin, E. H., Grote, P., Kispert, A., Beckers, A., Gossler, A., Werber, M. and Herrmann, B. G. (2007). Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. EMBO Rep. 8, 784-789.
30. Yagi, T., Tokunaga, T., Furuta, Y., Nada, S., Yoshida, M., Tsukada, T., Saga, Y., Takeda, N., Ikawa, Y. and Aizawa, S. (1993). A novel ES cell line, TT2, with high germline-differentiating potency. Anal. Biochem. 214, 70-76.
31. Yasuhiko, Y., Haraguchi, S., Kitajima, S., Takahashi, Y., Kanno, J. and Saga, Y. (2006). Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression. Proc. Natl. Acad. Sci. USA 103, 3651-3656.