Histological and immunohistochemical evaluation of duodenal and colonic biopsies after oral bovine lactoferrin supplementation in beagle puppies

Journal of Animal Physiology and Animal Nutrition

Volumn 93, Issue 1, 2009, Pages 76-82

  Handl, S ^a   Wehr, U ^b   Zentek, J ^a   Krammer Lukas, S ^c  

^a UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^b UNIVERSITY OF MUNICH   (Germany)

^c DSM NUTRITIONAL PRODUCTS LTD   (Switzerland)

Author keywords

Biopsies; Lactoferrin; Lymphocytes; Plasma cells; Puppies

Indexed keywords

LACTOFERRIN;

ANIMAL; ANIMAL DISEASE; ANIMAL FOOD; ARTICLE; CATTLE; COLON; DIET SUPPLEMENTATION; DOG; DOSE RESPONSE; DRUG EFFECT; DUODENUM; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; INTESTINE MUCOSA; LYMPHOCYTE; MALE; MUCOSAL IMMUNITY; NEWBORN; ORAL DRUG ADMINISTRATION; RANDOMIZATION;

ADMINISTRATION, ORAL; ANIMAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; ANIMALS; ANIMALS, NEWBORN; CATTLE; COLON; DIETARY SUPPLEMENTS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DUODENUM; FEMALE; IMMUNITY, MUCOSAL; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; LACTOFERRIN; LYMPHOCYTES; MALE; RANDOM ALLOCATION;

BOVINAE; CANIS FAMILIARIS; MAMMALIA; MUS;

EID: 58149343541     PISSN: 09312439     EISSN: 14390396     Source Type: Journal    
DOI: 10.1111/j.1439-0396.2007.00781.x     Document Type: Article

References (43)

1. Arnold, D. Di Biase, A. M. Marchetti, M. Pietrantoni, A. Valenti, P. Seganti, L. Superti, F., 2002 : Antiadenovirus activity of milk proteins: lactoferrin prevents viral infection. Antiviral Research 53, 153 158.
2. Artym, J. Zimecki, M. Paprocka, M. Kruzel, M. L., 2003 : Orally administered lactoferrin restores humoral immune response in immunocompromised mice. Immunology Letters 89, 9 15.
3. Ashida, K. Sasaki, H. Suzuki, Y. Loennerdal, B., 2004 : Cellular internalization of lactoferrin in intestinal epithelial cells. Biometals 17, 311 315.
4. Baker, H. M. Baker, E. N., 2004 : Lactoferrin and iron: structural and dynamic aspects of binding and release. Biometals 17, 209 216.
5. Bellamy, W. Takase, M. Yamauchi, K. Wakabayashi, H. Kawase, K. Tomita, M., 1992 : Identification of the bactericidal domain of lactoferrin. Biochimica et Biophysica Acta 1121, 130 139.
6. Bellamy, W. Wakabayashi, H. Takase, M. Kawase, K. Shimamura, S. Tomita, M., 1993 : Killing of Candida albicans by lactoferrin B, a potent antimicrobial peptid derived from the N-terminal region of bovine lactoferrin. Medical Microbiology and Immunology 182, 97 105.
7. Brock, J. H., 2002 : The physiology of lactoferrin. Biochemical Cell Biology 80, 1 6.
8. Debbabi, H. Dubarry, M. Rautureau, M. Tomé, D., 1998 : Bovine lactoferrin induces both mucosal and systemic immune response in mice. Journal of Dairy Research 65, 283 293.
9. Drobni, P. Naeslund, J. Evander, M., 2004 : Lactoferrin inhibits human papillomavirus binding and uptake in vitro. Antiviral Research 64, 63 68.
10. Fuerdoes, I., 2005 : Lactoferrin as Feed Additive in the Adult Dog and its Effect on the Immune System and the Intestinal Flora. Dissertation, University of Veterinary Medicine, Vienna.
11. German, A. J. Hall, E. J. Moore, P. F. Ringler, D. J. Newman, W. Day, M. J., 1999 : The distribution of lymphocytes expressing alphabeta and gammadelta T-cell receptors, and the expression of mucosal addressin cell adhesion molecule-1 in the canine intestine. Journal of Comparative Pathology 121, 249 263.
12. Gislason, J. Iyer, S. Douglas, G. C. Hutchen, T. W. Loennerdal, B., 1994 : Binding of porcine milk lactoferrin to piglet intestinal lactoferrin receptor. Advances in Experimental Medicine and Biology 357, 239 244.
13. Guilford, W. G., 1996 : Gastrointestinal immune system. In : W. G. Guilford, C. A. Center, D. R. Strombeck, D. A. Williams, D. J. Meyer (eds Strombeck's Small Animal Gastroenterology, 3rd edn. Saunders, Philadelphia, pp. 20 39.
14. Hart, I. R., 1979 : The distribution of immunoglobulin-containing cells in canine small intestine. Research in Veterinary Science 27, 269 274.
15. Hellweg, P. I., 2005 : Dietetic Influences on the Immune System of Dogs. Dissertation, University of Veterinary Medicine, Vienna.
16. Hu, W. L. Mazurier, J. Montreuil, J. Spik, G., 1990 : Isolation and partial characterisation of a lactotransferrin receptor from mouse intestinal brush border. Biochemistry 29, 535 541.
17. Jergens, A. E. Moore, F. M. Kaise, M. S. Haynes, J. S. Kinyon, J. M., 1996 : Morphometric evaluation of immunoglobulin A-containing and immunoglobulin G-containing cells and T cells in duodenal mucosa from healthy dogs and from dogs with inflammatory bowel disease or nonspecific gastroenteritis. American Journal of Veterinary Research 57, 697 704.
18. Jergens, A. E. Gamet, Y. Niyo, Y. Bailey, T. B. Brabec, M. Smith, B., 1998 : Immunohistochemical characterisation of immunoglobulin-containing cells and T cells in the colonic mucosa of healthy dogs. American Journal of Veterinary Research 57, 552 556.
19. Kelleher, S. L. Loennerdal, B., 2001 : Immunological activities associated with milk. Advances in Food and Nutrition Research 10, 39 65.
20. Kim, W. S. Ohashi, M. Tanaka, T. Kumura, H. Kim, G. Y. Kwon, I. K. Goh, J. S. Shimazaki, K. I., 2004 : Growth-promoting effects of lactoferrin on L. acidophilus and Bifidobacterium spp. Biometals 17, 279 283.
21. Kuwata, H. Yamauchi, K. Teraguchi, S. Hayasawa, H., 2002 : Metabolic fate of ingested lactoferrin in adult rats. Biochemical Cell Biology 80, 142.
22. Laur, P. F., 2003 : Influence of Lactoferrin on the Organism of Newborn Dog Puppies. Dissertation, Faculty of Veterinary Medicine, Ludwig Maximilian University, Munich.
23. Liepke, C. Adermann, K. Raida, M. Maegert, H. J. Forssmann, W. G. Zucht, H. D., 2002 : Human milk provides peptides highly stimulating the growth of bifidobacteria. European Journal of Biochemistry 269, 712 718.
24. Loennerdal, B., 1994 : Lactoferrin receptors in intestinal brush border membranes. Advances in Experimental Medicine and Biology 357, 171 175.
25. Masson, P. L. Heremans, J. F., 1971 : Lactoferrin in milk from different species. Comparative Biochemistry and Physiology 39B, 119 129.
26. Meyer, H. Zentek, J., 2005 : Praktische Fütterung Saug- und Absetzwelpen. Ernährungs- und haltungsbedingte Krankheiten und Todesfälle. In : Ernährung des Hundes. 5. Aufl, Paul Parey, Stuttgart, pp. 163.
27. Pope, L. L. Flickinger, E. A. Karr-Lilienthal, L. K. Spears, J. K. Krammer, S. Fahey, G. C. Jr., 2006 : Effects of lactoferrin supplementation on ileal and total tract nutrient digestibility, gastrointestinal microbial populations, and immune characteristics of ileal cannulated, healthy, adult dogs. Archives of Animal Nutrition 60, 10 22.
28. Prgomet, C. Prenner, M. L. Schwarz, F. J. Pfaffl, M. W., 2007 : Effect of lactoferrin on selected immune system parameters and the gastrointestinal morphology in growing calves. Journal of Animal Physiology and Animal Nutrition 91, 109 119.
29. Robblee, E. D. Erickson, P. S. Whitehouse, N. L. McLauglin, A. M. Schwab, C. G Rejman, J. J. Rompala, R. E., 2003 : Supplemental lactoferrin improves health and growth of holstein calves during the weaning phase. Journal of Dairy Science 86, 1458 1464.
30. Rothkoetter, H. J. Moellhoff, S. Pabst, R., 1999 : The influence of age and breeding conditions on the number and proliferation of intraepithelial lymphocytes in pigs. Scandinavian Journal of Immunology 50, 31 38.
31. Sonea, I. M. Harkins, K. Wannemuehler, M. J. Jergens, A. E. Merten, E. A. Sacco, R. E. Cunnick, J. E., 1999 : Flow cytometric analysis of canine colonic mucosal lymphocytes from endoscopically obtained biopsy specimens. American Journal of Veterinary Research 60, 346 353.
32. Sonea, I. M. Jergens, A. E. Sacco, R. E. Niyo, Y. Merten, E. Kauffman, L. K. Moore, P. F., 2000 : Flow cytometric analysis of colonic and small intestinal mucosal lymphocytes obtained by endoscopic biopsy in the healthy dog. Veterinary Immunology and Immunopathology 77, 103 119.
33. Talukder, M. J. R. Takeuchi, T. Harada, E., 2003 : Characteristics of lactoferrin receptor in bovine intestine: higher binding activity to the epithelium overlying Peyer's patches. Journal of Veterinary Medicine A 50, 123 131.
34. Tanaka, T. Nakatani, S. Xuan, X. Kumura, H. Igarashi, I. Shimazaki, K. I., 2003 : Antiviral activity of lactoferrin against canine herpesvirus. Antiviral Research 60, 193 199.
35. Unsoeld, E., 2003 : Model of Orphan Rearing for Testing the Efficacy of Probiotic Substances. Dissertation, Faculty of Veterinary Medicine, Ludwig Maximilian University, Munich.
36. Vaerman, J. P. Heremans, J. F., 1969 : Distribution of various immunoglobulin containing cells in canine lymphoid tissue. Immunology 17, 627 633.
37. Van Leeuwen, P. Oosting, S. J. Mouwen, J. M. V. M. Verstegen, M. W. A., 2000 : Effects of a lactoperoxidase system and lactoferrin, added to a milk replacer diet, on severity of diarrhoea, intestinal morphology and microbiology of digesta and faeces in young calves. Journal of Animal Physiology and Animal Nutrition 83, 15 23.
38. Wakabayashi, H. Uchida, K. Yamauchi, K. Teraguchi, S. Hayasawa, H. Yamaguchi, H., 2000 : Lactoferrin given in food facilitates dermatophytosis cure in guinea pig models. Journal of Antimicrobial Chemotherapy 46, 595 601.
39. Wakabayashi, H. Takakura, N. Kuwata, H. Yamauchi, K. Teraguchi, S. Hayasawa, H., 2002 : Analysis of leukocyte population changes in lactoferrin-fed mice. Biochemical Cell Biology 80, 145.
40. Wang, W. P. Iigo, M. Sato, J. Sekine, K. Adachi, I. Tsuda, H., 2000 : Activation of intestinal mucosal immunity in tumor-bearing mice by lactoferrin. Japanese Journal of Cancer Research 91, 1022 1027.
41. Zagulski, T. Jarzabeck, Z. Zagulska, A. Zimecki, M., 1998 : The main systemic, highly effective, and quickly acting antimicrobial mechanisms generated by lactoferrin in mammals in vivo. Activity in health and disease. In : G. Spik, D. Legrand, J. Mazurier, A. Pierce, J. P. Perraudin (eds Advances in Lactoferrin Research. Plenum Press, New York. Advances in Experimental Medicine and Biology 443, 247 250.
42. Zentek, J. Hall, E. J. German, A. Haverson, K. Bailey, M. Rolfe, V. Butterwick, R. Day, M. J., 2002 : Morphology and immunopathology of the small and large intestine in dogs with nonspecific dietary sensitivity. Journal of Nutrition 132, 1652S 1654S.
43. Zimecki, M. Wlaszczyk, A. Cheneau, P. Brunel, A. S. Mazurier, J. Spik, G. Kuebler, A., 1998 : Immunoregulatory effects of a nutritional preparation containing bovine lactoferrin taken orally by healthy individuals. Archivum Immunologie et Therapiae Experimentalis 46, 231 240.