Four weeks high fat feeding induces insulin resistance without affecting dopamine release or gene expression patterns in the hypothalamus of C57Bl6 mice

Brain Research

Volumn 1250, Issue , 2009, Pages 141-148

  de Leeuw van Weenen, J E ^a   Hu, L ^a   Jansen Van Zelm, K ^b   de Vries, M G ^b   Tamsma, J T ^a   Romijn, J A ^a   Pijl, H ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b CHARLES RIVER LABORATORIES   (United States)

Author keywords

Diabetes Mellitus type 2; Dopamine; Dopamine receptor; Hypothalamus; Insulin resistance; Mice

Indexed keywords

DOPAMINE; DOPAMINE RECEPTOR; DOPAMINE TRANSPORTER; FAT; GLUCOSE; INSULIN; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; DIET; DISEASE COURSE; DOPAMINE RELEASE; DOPAMINERGIC TRANSMISSION; FAT INTAKE; GENE EXPRESSION; HYPERINSULINEMIA; HYPOTHALAMUS; IN VIVO STUDY; INSULIN RESISTANCE; MALE; METABOLISM; MOUSE; NEUROTRANSMISSION; NONHUMAN; OBESITY; PRIORITY JOURNAL; REFEEDING; THALAMUS DORSOMEDIAL NUCLEUS;

ANIMALS; BLOOD GLUCOSE; DIET; DIETARY FATS; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; HYPERINSULINISM; HYPOTHALAMUS; INSULIN; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; TYROSINE 3-MONOOXYGENASE;

ANIMALIA; MUS;

EID: 58149310904     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.11.004     Document Type: Article

References (48)

1. Ader M., Kim S.P., Catalano K.J., et al. Metabolic dysregulation with atypical antipsychotics occurs in the absence of underlying disease: a placebo-controlled study of olanzapine and risperidone in dogs. Diabetes 54 (2005) 862-871
2. Anderzhanova E., Covasa M., and Hajnal A. Altered basal and stimulated accumbens dopamine release in obese OLETF rats as a function of age and diabetic status. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 (2007) R603-R611
3. Avena N.M., Rada P., and Hoebel B.G. Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci. Biobehav. Rev. 32 (2008) 20-39
4. Baptista T., Parada M., and Hernandez L. Long term administration of some antipsychotic drugs increases body weight and feeding in rats. Are D2 dopamine receptors involved?. Pharmacol. Biochem. Behav. 27 (1987) 399-405
5. Baptista T., Araujo D.B., Ying Kin N.M., et al. Comparative effects of the antipsychotics sulpiride or risperidone in rats. I: bodyweight, food intake, body composition, hormones and glucose tolerance. Brain Res. 957 (2002) 144-151
6. Bellinger L.L., and Bernardis L.L. The dorsomedial hypothalamic nucleus and its role in ingestive behavior and body weight regulation: lessons learned from lesioning studies. Physiol. Behav. 76 (2002) 431-442
7. Bello N.T., and Hajnal A. Alterations in blood glucose levels under hyperinsulinemia affect accumbens dopamine. Physiol. Behav. 88 (2006) 138-145
8. Bina K.G., and Cincotta A.H. Dopaminergic agonists normalize elevated hypothalamic neuropeptide Y and corticotropin-releasing hormone, body weight gain, and hyperglycemia in ob/ob mice. Neuroendocrinology 71 (2000) 68-78
9. Brunetti L., Michelotto B., Orlando G., and Vacca M. Leptin inhibits norepinephrine and dopamine release from rat hypothalamic neuronal endings. Eur. J. Pharmacol. 372 (1999) 237-240
10. Carvelli L., Moron J.A., Kahlig K.M., et al. PI 3-kinase regulation of dopamine uptake. J. Neurochem. 81 (2002) 859-869
11. Cincotta A.H., and Meier A.H. Reductions of body fat stores and total plasma cholesterol and triglyceride concentrations in several species by bromocriptine treatment. Life Sci. 45 (1989) 2247-2254
12. Cincotta A.H., Tozzo E., and Scislowski P.W. Bromocriptine/SKF38393 treatment ameliorates obesity and associated metabolic dysfunctions in obese (ob/ob) mice. Life Sci. 61 (1997) 951-956
13. Clark K.A., MohanKumar S.M., Kasturi B.S., and MohanKumar P.S. Effects of central and systemic administration of leptin on neurotransmitter concentrations in specific areas of the hypothalamus. Am. J. Physiol. Regul. Integr. Comp. Physiol. 290 (2006) R306-R312
14. Comings D.E., and Blum K. Reward deficiency syndrome: genetic aspects of behavioral disorders. Prog. Brain Res. 126 (2000) 325-341
15. Davis L.M., Pei Z., Trush M.A., et al. Bromocriptine reduces steatosis in obese rodent models. J. Hepatol. 45 (2006) 439-444
16. Enriori P.J., Evans A.E., Sinnayah P., and Cowley M.A. Leptin resistance and obesity. Obesity. (Silver Spring) 14 Suppl. 5 (2006) 254S-258S
17. Fetissov S.O., Meguid M.M., Sato T., and Zhang L.H. Expression of dopaminergic receptors in the hypothalamus of lean and obese Zucker rats and food intake. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283 (2002) R905-R910
18. Figlewicz D.P., Szot P., Chavez M., Woods S.C., and Veith R.C. Intraventricular insulin increases dopamine transporter mRNA in rat VTA/substantia nigra. Brain Res. 644 (1994) 331-334
19. Garcia B.G., Wei Y., Moron J.A., Lin R.Z., Javitch J.A., and Galli A. Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution. Mol. Pharmacol. 68 (2005) 102-109
20. Haltia L.T., Rinne J.O., Merisaari H., et al. Effects of intravenous glucose on dopaminergic function in the human brain in vivo. Synapse 61 (2007) 748-756
21. Hamdi A., Porter J., and Prasad C. Decreased striatal D2 dopamine receptors in obese Zucker rats: changes during aging. Brain Res. 589 (1992) 338-340
22. Hamilton M.E., and Freeman A.S. Effects of administration of cholecystokinin into the VTA on DA overflow in nucleus accumbens and amygdala of freely moving rats. Brain Res. 688 (1995) 134-142
23. Kok P., Roelfsema F., Frolich M., et al. Activation of dopamine D2 receptors simultaneously ameliorates various metabolic features of obese women. Am. J. Physiol. Endocrinol. Metab. 291 (2006) E1038-E1043
24. Koshimura K., Tanaka J., Murakami Y., and Kato Y. Effect of high concentration of glucose on dopamine release from pheochromocytoma-12 cells. Metabolism 52 (2003) 922-926
25. Krugel U., Schraft T., Kittner H., Kiess W., and Illes P. Basal and feeding-evoked dopamine release in the rat nucleus accumbens is depressed by leptin. Eur. J. Pharmacol. 482 (2003) 185-187
26. Kuo D.Y. Co-administration of dopamine D1 and D2 agonists additively decreases daily food intake, body weight and hypothalamic neuropeptide Y level in rats. J. Biomed. Sci. 9 (2002) 126-132
27. Lemierre S., Rouch C., Nicolaidis S., and Orosco M. Combined effect of obesity and aging on feeding-induced monoamine release in the rostromedial hypothalamus of the Zucker rat. Int. J. Obes. Relat. Metab. Disord. 22 (1998) 993-999
28. Levin B.E., and Dunn-Meynell A.A. Dysregulation of arcuate nucleus preproneuropeptide Y mRNA in diet-induced obese rats. Am. J. Physiol. 272 (1997) R1365-R1370
29. Levin B.E., Triscari J., and Sullivan A.C. The effect of diet and chronic obesity on brain catecholamine turnover in the rat. Pharmacol. Biochem. Behav. 24 (1986) 299-304
30. Luo S., Liang Y., and Cincotta A.H. Intracerebroventricular administration of bromocriptine ameliorates the insulin-resistant/glucose-intolerant state in hamsters. Neuroendocrinology 69 (1999) 160-166
31. Meguid M.M., Fetissov S.O., Varma M., et al. Hypothalamic dopamine and serotonin in the regulation of food intake. Nutrition 16 (2000) 843-857
32. Meier A.H., and Cincotta A.H. Circadian Rhythms regulate the expression of the thrifty genotype/phenotype. Diabetes Rev. 4 (1996) 464-487
33. Morton G.J., Cummings D.E., Baskin D.G., Barsh G.S., and Schwartz M.W. Central nervous system control of food intake and body weight. Nature 443 (2006) 289-295
34. Nestler E.J. Hard target: understanding dopaminergic neurotransmission. Cell 79 (1994) 923-926
35. Newcomer J.W. Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. CNS Drugs 19 Suppl. 1 (2005) 1-93
36. Orosco M., Gerozissis K., Rouch C., Meile M.J., and Nicolaidis S. Hypothalamic monoamines and insulin in relation to feeding in the genetically obese Zucker rat as revealed by microdialysis. Obes. Res. 3 Suppl. 5 (1995) 655S-665S
37. Orosco M., Rouch C., Meile M.J., and Nicolaidis S. Spontaneous feeding-related monoamine changes in rostromedial hypothalamus of the obese Zucker rat: a microdialysis study. Physiol. Behav. 57 (1995) 1103-1106
38. Patterson T.A., Brot M.D., Zavosh A., Schenk J.O., Szot P., and Figlewicz D.P. Food deprivation decreases mRNA and activity of the rat dopamine transporter. Neuroendocrinology 68 (1998) 11-20
39. Paxinos G., and Franklin K.B.J. The Mouse Brain in Stereotaxic Coordinates (2001), Academic Press, San Diego
40. Pijl H. Reduced dopaminergic tone in hypothalamic neural circuits: expression of a "thrifty" genotype underlying the metabolic syndrome?. Eur. J. Pharmacol. 480 (2003) 125-131
41. Pijl H., Ohashi S., Matsuda M., et al. Bromocriptine: a novel approach to the treatment of type 2 diabetes. Diabetes Care 23 (2000) 1154-1161
42. Scislowski P.W., Tozzo E., Zhang Y., Phaneuf S., Prevelige R., and Cincotta A.H. Biochemical mechanisms responsible for the attenuation of diabetic and obese conditions in ob/ob mice treated with dopaminergic agonists. Int. J. Obes. Relat. Metab. Disord. 23 (1999) 425-431
43. Voshol P.J., Jong M.C., Dahlmans V.E., et al. In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake. Diabetes 50 (2001) 2585-2590
44. Wang G.J., Volkow N.D., Logan J., et al. Brain dopamine and obesity. Lancet 357 (2001) 354-357
45. Yamato T., Misumi Y., Yamasaki S., Kino M., and Aomine M. Diabetes mellitus decreases hippocampal release of neurotransmitters: an in vivo microdialysis study of awake, freely moving rats. Diabetes Nutr. Metab. 17 (2004) 128-136
46. Yang Z.J., and Meguid M.M. LHA dopaminergic activity in obese and lean Zucker rats. NeuroReport 6 (1995) 1191-1194
47. Zhou Q.Y., and Palmiter R.D. Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell 83 (1995) 1197-1209
48. Zhu J.N., Guo C.L., Li H.Z., and Wang J.J. Dorsomedial hypothalamic nucleus neurons integrate important peripheral feeding-related signals in rats. J. Neurosci. Res. 85 (2007) 3193-3204