Prevalence of Helicobacter pylori pathogenicity-associated cagA and vacA genotypes among Pakistani dyspeptic patients: RESEARCH ARTICLE

FEMS Immunology and Medical Microbiology

Volumn 55, Issue 1, 2009, Pages 34-38

  Ahmad, Tanvir ^b   Sohail, Khawar ^a   Rizwan, Muhammad ^a   Mukhtar, Muhammad ^a   Bilal, Rakhshanda ^b   Khanum, Azra ^a  

^a PMAS ARID AGRICULTURE UNIVERSITY   (Pakistan)

^b IAD   (Pakistan)

Author keywords

CagA; Helicobacter pylori; VacA

Indexed keywords

BACTERIAL DNA; RNA 16S;

ADULT; ALLELE; ARTICLE; BACTERIAL GENE; CAGA GENE; DNA DETERMINATION; DNA ISOLATION; DYSPEPSIA; GENETIC VARIABILITY; GENOTYPE; HELICOBACTER PYLORI; HUMAN; MAJOR CLINICAL STUDY; PAKISTAN; PATHOGENICITY; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; STOMACH BIOPSY; VACA GENE; VIRULENCE;

ADULT; AGED; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BIOPSY; DNA, BACTERIAL; FEMALE; GASTRIC MUCOSA; GENOTYPE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; MIDDLE AGED; PAKISTAN; POLYMERASE CHAIN REACTION; PREVALENCE; RNA, BACTERIAL; RNA, RIBOSOMAL, 16S; VIRULENCE FACTORS;

EID: 58149308260     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2008.00492.x     Document Type: Article

References (32)

1. Abbas Z, Fareed R, Baig MN, Khan TN Shah MA (2001) Prevalence of histological reflux oesophagitis in H. pylori positive patients: effect of density of H. pylori and activity of inflammation. J Pak Med Assoc 51 : 36 41.
2. Arachchi HS, Kalra V, Lal B et al 2007) Prevalence of duodenal ulcer-promoting gene (dupA) of Helicobacter pylori in patients with duodenal ulcer in North Indian population. Helicobacter 12 : 591 597.
3. 13C urea breath test's usefulness in the diagnosis of Helicobacter pylori infection. J Coll Physicians Surg Pak 9 : 75 77.
4. Atherton JC, Cao P, Peek RM Jr., Tummuru MK, Blaser MJ Cover TL (1995) Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 270 : 17771 17777.
5. Bani-Hani KE (2002) The current status of Helicobacter pylori. Saudi Med J 23 : 379 383.
6. Benenson S, Halle D, Rudensky B et al 2002) Helicobacter pylori genotypes in Israeli children: the significance of geography. J Pediatr Gastr Nutr 35 : 680 684.
7. Covacci A, Censini S, Bugnoli M et al 1993) Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. P Natl Acad Sci USA 90 : 5791 5795.
8. Dunn BE, Cohen H Blaser MJ (1997) Helicobacter pylori. Clin Microbiol Rev 10 : 720 741.
9. Erzin Y, Koksal V, Altun S et al 2006) Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA, babA2 genotypes and correlation with clinical outcome in Turkish patients with dyspepsia. Helicobacter 11 : 574 580.
10. Gramley WA, Asghar A, Frierson HF Jr. Powell SM (1999) Detection of Helicobacter pylori DNA in fecal samples from infected individuals. J Clin Microbiol 37 : 2236 2240.
11. Hocker M Hohenberger P (2003) Helicobacter pylori virulence factors - one part of a big picture. Lancet 362 : 1231 1233.
12. Kamali-Sarvestani E, Bazargani A, Masoudian M, Lankarani K, Taghavi AR Saberifiroozi M (2006) Association of H. pylori cagA and vacA genotypes and IL-8 gene polymorphisms with clinical outcome of infection in Iranian patients with gastrointestinal diseases. World J Gastroentero 12 : 5205 5210.
13. Mishra KK, Srivastava S, Dwivedi PP, Prasad KN Ayyagari A (2002) Genotypes of Helicobacter pylori isolated from various acid peptic diseases in and around Lucknow. Curr Sci 83 : 749 755.
14. Nimri LF, Matalka I, Bani Hani K Ibrahim M (2006) Helicobacter pylori genotypes identified in gastric biopsy specimens from Jordanian patients. BMC Gastroenterol 6 : 27.
15. Peek RM Jr., Moss SF, Tham KT et al 1997) Helicobacter pylori cagA+strains and dissociation of gastric epithelial cell proliferation from apoptosis. J Natl Cancer I 89 : 863 868.
16. Proenca Modena JL, Lopes Sales AI, Olszanski Acrani G et al 2007) Association between Helicobacter pylori genotypes and gastric disorders in relation to the cag pathogenicity island. Diagn Micr Infec Dis 59 : 7 16.
17. Qiao W, Hu JL, Xiao B, Wu KC, Peng DR, Atherton JC Xue H (2003) cagA and vacA genotype of Helicobacter pylori associated with gastric diseases in Xi'an area. World J Gastroentero 9 : 1762 1766.
18. Sambrook J Russell D (2001) Molecular Cloning: A Laboratory Manual, 3rd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
19. Santos IS, Boccio J, Santos AS, Valle NC, Halal CS, Bachilli MC Lopes RD (2005) Prevalence of Helicobacter pylori infection and associated factors among adults in Southern Brazil: a population-based cross-sectional study. BMC Public Health 5 : 118.
20. Sarker SA, Nahar S, Rahman M, Bardhan PK, Nair GB, Beglinger C Gyr N (2004) High prevalence of cagA and vacA seropositivity in asymptomatic Bangladeshi children with Helicobacter pylori infection. Acta Paediatr 93 : 1432 1436.
21. Soylu OB Ozturk Y (2008) Helicobacter pylori infection: effect on malnutrition and growth failure in dyspeptic children. Eur J Pediatr 167 : 557 562.
22. Taj Y, Essa F, Kazmi SU Abdullah E (2003) Sensitivity and specificity of various diagnostic tests in the detection of Helicobacter pylori. J Coll Physicians Surg Pak 13 : 90 93.
23. Telford JL, Ghiara P, Dell'Orco M et al 1994) Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease. J Exp Med 179 : 1653 1658.
24. The EUROGAST Study Group (1993) Epidemiology of, and risk factors for, Helicobacter pylori infection among 3194 asymptomatic subjects in 17 populations. Gut 34 : 1672 1676.
25. Van Doorn LJ, Figueiredo C, Rossau R et al 1998) Typing of Helicobacter pylori vacA gene and detection of cagA gene by PCR and reverse hybridization. J Clin Microbiol 36 : 1271 1276.
26. Van Doorn LJ, Figueiredo C, Megraud F et al 1999) Geographic distribution of vacA allelic types of Helicobacter pylori. Gastroenterology 116 : 823 830.
27. Yakoob J, Jafri N, Jafri W et al 2004) Polymerase chain reaction in the detection of Helicobacter pylori infection. J Coll Physicians Surg Pak 14 : 153 156.
28. Yakoob J, Jafri W, Jafri N et al 2005) Prevalence of non-Helicobacter pylori duodenal ulcer in Karachi, Pakistan. World J Gastroentero 11 : 3562 3565.
29. Yakoob J, Abid S, Abbas N et al 2007) Significance of cagA status and vacA subtypes of Helicobacter pylori in determining gastric histopathology in Pakistan. Helicobacter 12 : 417, abstract no. P033.
30. Yamaoka Y, Kodama T, Gutierrez O, Kim JG, Kashima K Graham DY (1999) Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries. J Clin Microbiol 37 : 2274 2279.
31. Yamazaki S, Yamakawa A, Okuda T et al 2005) Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori associated with peptic ulcer in Japan. J Clin Microbiol 43 : 3906 3916.
32. Zheng PY, Hua J, Yeoh KG Ho B (2000) Association of peptic ulcer with increased expression of Lewis antigens but not cagA, iceA, and vacA in Helicobacter pylori isolates in an Asian population. Gut 47 : 18 22.