Directional transcellular transport of bisoprolol in P-glycoprotein-expressed LLC-GA5-COL150 cells, but not in renal epithelial LLC-PK1 cells

Drug Metabolism and Pharmacokinetics

Volumn 23, Issue 5, 2008, Pages 340-346

  Tahara, Katsutoshi ^a   Kagawa, Yuka ^a   Takaai, Mari ^a   Taguchi, Masato ^a   Hashimoto, Yukiya ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Bisoprolol; Cationic drugs; Kidney epithelial cell line; Kinetic analysis; Renal secretion; Transcellular transport

Indexed keywords

BISOPROLOL; CIMETIDINE; GLYCOPROTEIN P; NICOTINE; QUINIDINE; TETRYLAMMONIUM; ORGANIC CATION TRANSPORTER;

ACTIVE TRANSPORT; ANIMAL CELL; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CELL TRANSPORT; CONTROLLED STUDY; DRUG CLEARANCE; DRUG TRANSPORT; KIDNEY EPITHELIUM; KIDNEY TUBULE EXCRETION; NONHUMAN; SWINE; ANIMAL; CELL CULTURE; CELL STRAIN; COMPARATIVE STUDY; EVALUATION; METABOLISM;

ANIMALS; BISOPROLOL; CELLS, CULTURED; CIMETIDINE; LLC-PK1 CELLS; ORGANIC CATION TRANSPORT PROTEINS; P-GLYCOPROTEIN; QUINIDINE; SWINE; TETRAETHYLAMMONIUM;

EID: 58149306052     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.23.340     Document Type: Article

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