RAF may induce cell proliferation through hypermethylation of tumor suppressor gene promoter in gastric epithelial cells

Cancer Science

Volumn 100, Issue 1, 2009, Pages 117-125

  Wang, Xia ^a,b   Sun, Dan Feng ^a   Lu, Rong ^a   Chen, Zhao Fei ^a   Chen, Ying Xuan ^a   Fang, Jing Yuan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b HANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLINE; DNA; RAF PROTEIN; TUMOR SUPPRESSOR PROTEIN;

AGAR MEDIUM; ARTICLE; CANCER CELL; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DNA METHYLATION; EPITHELIUM CELL; GENE INACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INDUCTION; STOMACH EPITHELIUM;

CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DNA METHYLATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; GASTRIC MUCOSA; GENES, P16; GENES, TUMOR SUPPRESSOR; HUMANS; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; RAF KINASES; STOMACH NEOPLASMS;

EID: 58149299314     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2008.01017.x     Document Type: Article

References (34)

1. Neureiter D, Herold C, Ocker M. Gastrointestinal cancer - only a deregulation of stem cell differentiation? (Review). Int J Mol Med 2006; 17: 483-9.
2. Fang JY, Richardson BC. The MAPK signalling pathways and colorectal cancer. Lancet Oncol 2005; 6: 322-7.
3. Sasao S, Hiyama T, Tanaka S, Yoshihara M, Yasui W, Chayama K. Clinicopathologic and genetic characteristics of gastric cancer in young male and female patients. Oncol Rep 2006; 16: 11-15.
4. Lee SH, Lee JW, Soung YH et al. BRAF and KRAS mutations in stomach cancer. Oncogene 2003; 22: 6942-5.
5. Hirasawa Y, Arai M, Imazeki F et al. Methylation status of genes upregulated by demethylating agent 5-aza-2′-deoxycytidine in hepatocellular carcinoma. Oncology 2006; 71: 77-85.
6. Robertson KD, Wolffe AP. DNA methylation in health and disease. Nat Rev Genet 2000; 1: 11-19.
7. Scarano MI, Strazzullo M, Matarazzo MR, D'Esposito M. DNA methylation 40 years later: Its role in human health and disease. J Cell Physiol 2005; 204: 21-35.
8. MacLeod AR, Rouleau J, Szyf M. Regulation of DNA methylation by the Ras signaling pathway. J Biol Chem 1995; 270: 11327-37.
9. Rouleau J, MacLeod AR, Szyf M. Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway. J Biol Chem 1995; 270: 1595-601.
10. Esteller M, Toyota M, Sanchez-Cespedes M et al. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res 2000; 60: 2368-71.
11. Lu R, Wang X, Chen ZF, Sun DF, Tian XQ, Fang JY. Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells. J Biol Chem 2007; 282: 12249-59.
12. Reiners JJ Jr, Lee JY, Clift RE, Dudley DT, Myrand SP. PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase. Mol Pharmacol 1998; 53: 438-45.
13. Primeau M, Gagnon J, Momparler RL. Synergistic antineoplastic action of DNA methylation inhibitor 5-AZA-2′-deoxycytidine and histone deacetylase inhibitor depsipeptide on human breast carcinoma cells. Int J Cancer 2003; 103: 177-84.
14. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
15. Benbow U, Tower GB, Wyatt CA, Buttice G, Brinckerhoff CE. High levels of MMP-1 expression in the absence of the 2G single nucleotide polymorphism is mediated by p38 and ERK1/2 mitogen-activated protein kinases in VMM5 melanoma cells. J Cell Biochem 2002; 86: 307-19.
16. Scanlan MJ, Gordon CM, Williamson B et al. Identification of cancer/ testis genes by database mining and mRNA expression analysis. Int J Cancer 2002; 98: 485-92.
17. Xiong Z, Wu AH, Bender CM et al. Mismatch repair deficiency and CpG island hypermethylation in sporadic colon adenocarcinomas. Cancer Epidemiol Biomarkers Prev 2001; 10: 799-803.
18. Shames DS, Minna JD, Gazdar AF. DNA methylation in health, disease, and cancer. Curr Mol Med 2007; 7: 85-102.
19. Shaul YD, Seger R. The MEK/ERK cascade: From signaling specificity to diverse functions. Biochim Biophys Acta 2007; 1773: 1213-26.
20. Davies H, Bignell GR, Cox C et al. Mutations of the BRAF gene in human cancer. Nature 2002; 417: 949-54.
21. Naderi S, Wang JY, Chen TT, Gutzkow KB, Blomhoff HK. cAMP-mediated inhibition of DNA replication and S phase progression: Involvement of Rb, p21Cip1, and PCNA. Mol Biol Cell 2005; 16: 1527-42.
22. Reuven H, Klein S, Levitzki A. The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cy i cle arrest. Eur J Biochem 2003; 270: 2759-72.
23. Han J, Tsukada Y, Hara E, Kitamura N, Tanaka T. Hepatocyte growth factor induces redistribution of p21 (CIP1) and p27 (KIP1) through ERK-dependent p16 (INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells. J Biol Chem 2005; 280: 31548-56.
24. Zhu H, Zhang L, Wu S et al. Induction of S-phase arrest and p21 overexpression by a small molecule 2 3-(2,3-dichlorophenoxy) propyl]amin o]ethanol in correlation with activation of ERK. Oncogene 2004; 23: 4984-92.
25. McMillan L, Butcher SK, Pongracz J, Lord JM. Opposing effects of butyrate and bile acids on apoptosis of human colon adenoma cells: differential activation of PKC and MAP kinases. Br J Cancer 2003; 88: 748-53.
26. Esteller M. CpG island hypermethylation and tumor suppressor genes: A booming present, a brighter future. Oncogene 2002; 21: 5427-40.
27. Pruitt K, Ulku AS, Frantz K et al. Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells. J Biol Chem 2005; 280: 23363-70.
28. Deng C, Kaplan MJ, Yang J et al. Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. Arthritis Rheum 2001; 44: 397-407.
29. Ramchandani S, Bhattacharya SK, Cervoni N, Szyf M. DNA methylation is a reversible biological signal. Proc Natl Acad Sci USA 1999; 96: 6107-12.
30. Rountree MR, Bachman KE, Herman JG, Baylin S. DNA methylation, chromatin inheritance, and cancer. Oncogene 2001; 20: 3156-65.
31. Detich N, Ramchandani S, Szyf M. A conserved 3′-untranslated element mediates growth regulation of DNA methyltransferase 1 and inhibits its transforming activity. J Biol Chem 2001; 276: 24881-90.
32. Ordway JM, Williams K, Curran T. Transcription repression in oncogenic transformation: Common targets of epigenetic repression in cells transformed by Fos, Ras or Dnmt1. Oncogene 2004; 23: 3737-48.
33. Bachman KE, Rountree MR, Baylin SB. Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. J Biol Chem 2001; 276: 32282-7.
34. Bigey P, Ramchandani S, Theberge J, Araujo FD, Szyf M. Transcriptional regulation of the human DNA Methyltransferase (dnmt1) gene. Gene 2000; 242: 407-18.