An acetone breath analyzer using cavity ringdown spectroscopy: An initial test with human subjects under various situations

Measurement Science and Technology

Volumn 19, Issue 10, 2008, Pages

  Wang, Chuji ^a   Surampudi, Anand B ^a  

^a MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

Acetone; Alcohol; Background subtraction method; Breath analyzer; CRDS; Diabetes

Indexed keywords

ABSORPTION SPECTRA; ALCOHOLS; MEDICAL PROBLEMS;

ALCOHOL CONSUMPTION; BACKGROUND SUBTRACTION METHOD; BREATH ANALYZERS; CAVITY RING-DOWN SPECTROSCOPY; CRDS; EXPLORATORY STUDIES; PARTS PER MILLIONS; SINGLE WAVELENGTH;

ACETONE;

EID: 58149292020     PISSN: 09570233     EISSN: 13616501     Source Type: Journal    
DOI: 10.1088/0957-0233/19/10/105604     Document Type: Article

References (60)

1. Rooth G and Ostenson S 1966 Acetone in alveolar air and the control of diabetes Lancet 2 1102-5
2. Musa-Veloso K, Likhodii S S and Cunnane S C 2002 Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals Am. J. Clin. Nutr. 76 65-70
3. Vichi S, Castellote A I, Pizzale L, Conte L S, Buxaderas S and Lopez-Tamames E 2003 Analysis of virgin olive oil volatile compounds by headspace solid-phase microextraction coupled to gas chromatography with mass spectrometric and flame ionization detection J. Chromatogr. A 983 19-33
4. Likhodii S S, Musa K and Cunnane S C 2002 Breath acetone as a measure of systemic ketosis assessed in a rat model of the ketogenic diet Clin. Chem. 48 115-20
5. Yuan H, Mester Z, Lord H and Pawliszyn J 2000 Automated in-tube solid phase microextraction coupled with liquid chromatography-electrospray ionization mass spectrometry for the determination of selected benzodiazepines J. Anal. Toxicol. 24 718-25
6. Phillips M, Herrera J, Krishnan S, Zain M, Greenberg J and Cataneo R N 1999 Variation in volatile organic compounds in the breath of normal humans J. Chromatogr. B 729 75-88
7. Deng C, Zhang J, Yu X, Zhang W and Zhang X 2004 Determination of acetone in human breath by gas chromatography-mass spectrometry and solid-phase microextraction with on-fiber derivatization J. Chromatogr. B 810 269-75
8. Anderson J C, Lamm W J E and Hlasatala M P 2005 Measuring airway exchange of endogenous acetone using a single-exhalation breathing maneuver J. Appl. Physiol. 100 880-9
9. Raymer J H, Thomas K W, Cooper S D, Whitaker D A and Pellizzari E D 1990 A device for sampling of human alveolar breath for the measurement of expired volatile organic compounds J. Anal. Toxicol. 14 337-44
10. Mendis S, Sobotka P A and Euler D E 1994 Pentane and isoprene in expired air from humans: gas-chromatographic analysis of single breath Clin. Chem. 40 1485-8
11. Henderson M J, Karger B A and Wrenshall G A 1952 Acetone in the breath. A study of acetone exhalation in diabetic and nondiabetic human subjects Diabetes 1 188-93
12. Phillips M 1997 Method for the collection and assay of volatile organic compounds in breath Anal. Biochem. 247 272-8
13. Miekisch W, Schubert J K, Vagts D A and Geiger K 2001 Analysis of volatile disease markers in blood Clin. Chem. 47 1053-60
14. Smith D, Wang T and Spanel P 2002 On-line, simultaneous quantification of ethanol, some metabolites and water vapour in breath following the ingestion of alcohol Physiol. Meas. 23 477-89
15. Diskin A M, Spanel P and Smith D 2003 Time variation of ammonia, acetone, isoprene and ethanol in breath: a quantitative SIFT-MS study over 30 days Physiol. Meas. 24 107-20
16. Turner C, Spanel P and Smith D 2006 A longitudinal study of ammonia, acetone and propanol in the exhaled breath of 30 subjects using selected ion flow tube mass spectrometry, SIFT-MS Physiol. Meas. 27 321-7
17. Smith D and Spanel P 2005 Selected ion flow tube mass spectrometry (SIFT-MS) for on-line trace gas analysis Mass Spectrom. Rev. 24 661-700
18. Teshima N, Li J, Toda K and Dasgupta P K 2005 Determination of acetone in breath Anal. Chim. Acta 535 189-99
19. Fleischer M, Simon E, Rumpel E, Ulmer H, Harbeck M, Wandel M, Fietzek C, Weimar U and Meixner H 2002 Detection of volatile compounds correlated to human diseases through breath analysis with chemical sensors Sensors Actuators B 83 245-9
20. Huang H, Zhou J, Chen S, Zeng L and Huang Y 2004 A highly sensitive QCM sensor coated with Ag+-ZSM-5 film for medical diagnosis Sensors Actuators B 101 316
21. O'Keefe A and Deacon D A G 1988 Cavity ring-down optical spectrometer for absorption measurements using pulsed laser sources Rev. Sci. Instrum. 59 2544-51
22. Busch K W and Busch M A (ed) 1999 Cavity Ringdown Spectroscopy: An Ultra-Trace Absorption Measurement Technique (ACS Symposium Series 720) (New York: Oxford University Press)
23. Berden G, Peeters R and Meijer G 2000 Cavity ring-down spectroscopy: experimental schemes and applications Int. Rev. Phys. Chem. 19 565-607
24. Paldus B A and Kachanov A A 2005 A historical overview of cavity-enhanced methods Can. J. Phys. 83 975-99
25. Mazurenka M, Orr-Ewing A J, Peverall R and Ritchie G A D 2005 Cavity ring-down and cavity enhanced spectroscopy using diode lasers Annu. Rep. Prog. Chem. Sect. C: Phys. Chem. 101 100-42
26. Dahnke H, Kleine D, Hering P and Mürtz M 2001 Real-time monitoring of ethane in human breath using mid-infrared cavity leak-out spectroscopy Appl. Phys. B 72 971-5
27. von Basum G, Halmer D, Hering P, Muertz M, Schiller S, Mueller F, Popp A and Kuehnemann F 2004 Parts per trillion sensitivity for ethane in air with an optical parametric oscillator cavity leak-out spectrometer Opt. Lett. 29 797-9
28. Halmer D, Thelen S, Hering P and Mürtz M 2006 Online monitoring of ethane traces in exhaled breath with a difference frequency generation spectrometer Appl. Phys. B 85 437-43
29. Halmer D, von Basum G, Hering P and Murtz M 2005 Mid-infrared cavity leak-out spectroscopy for ultrasensitive detection of carbonyl sulfide Opt. Lett. 30 2314-6
30. Bakhirkin Y A, Kosterev A A, Roller C, Curl R F and Tittel F K 2004 Mid-infrared quantum cascade laser based off-axis integrated cavity output spectroscopy for biogenic nitric oxide detection Appl. Opt. 43 2257-66
31. Silva M L, Sonnenfroh D M, Rosen D I, Allen M G and O'Keefe A 2005 Integrated cavity output spectroscopy measurements of NO levels in breath with a pulsed room-temperature QCL Appl. Phys. B 81 705-10
32. Bakhirkin Y A, Kosterev A A, Curl R, Tittel F K, Yarekha D A, Hvozdara L, Giovannini M and Faist J 2006 Subppbv nitric oxide concentration measurements using cw thermoelectrically cooled quantum cascade laser-based integrated cavity output spectroscopy Appl. Phys. B 82 149-54
33. Mürtz M 2005 Breath diagnostics using laser spectroscopy Opt. Photon. News (January) pp 30-5
34. Mürtz M, Dahnke H, Horstjann M, Kleine D, Thelen S and Hering P 2006 Ultra-sensitive trace gas detection for biomedical applications Spectrochim. Acta A 63 963-9
35. Risby T H 2005 Current Status of Clinical Breath Analysis. Breath Gas Analysis for Clinical Diagnosis and Therapeutic Monitoring ed A Amann and D Smith (Singapore: World Scientific Publishing) pp 251-66
36. McCurdy M M, Bakhirkin Y, Wysocki G, Lewwicki R and Tittle F K 2007 Recent advances of laser-spectroscopy-based techniques for applications in breath analysis J. Breath Res. 1 014001
37. Cao W and Duan Y 2007 Current status of methods and techniques for breath analysis Crit. Rev. Anal. Chem. 37 3-13
38. 12C for carbon dioxide in human breath Anal. Chem. 74 2003-7
39. Wahl E H et al 2006 Applications of cavity ring-down spectroscopy to high precision isotope ratio measurement of 13C/12C in carbon dioxide Isot. Environ. Health Stud. 42 21-35
40. Thorpe M J, Balslev-Clausen D, Kirchner M S and Ye J 2007 Cavity-enhanced optical frequency comb spectroscopy: application to human breath analysis Opt. Express 16 2387-97
41. Wang C, Scherrer S T and Hossain D 2004 Measurements of cavity ringdown spectroscopy of acetone in the ultraviolet and near-infrared spectral regions: potential for development of a breath analyzer Appl. Spectrosc. 58 784-91
42. Wang C 2005 Biomedical applications of cavity ringdown spectroscopy: present and perspective Abstracts, 57th Southeast/61st Southwest Joint Regional Meeting of the American Chemical Society (Memphis, TN, USA, 1-4 November 2005)
43. Wang C and Mbi A 2007 A new acetone detection device using cavity ringdown spectroscopy at 266 nm: evaluation of the instrument performance using acetone sample solutions Meas. Sci. Technol. 18 2731-41
44. Glaubitt D and Rausch-Stroomann J G 1959 A new method for determination of acetone in expired air Clin. Chim. Acta 4 165-9
45. Levey S, Balchum O J, Medrano V and Jung R 1964 Metabolic products in expired air: II. Acetone J. Lab. Clin. Med. 63 574-84
46. Brechner V L and Bethune R W 1965 Determination of acetone concentration in arterial blood by vapor phase chromatography of alveolar gas Diabetes 14 663-5
47. Tassopoulos C N, Barnett D and Fraser T R 1969 Breath-acetone and blood-sugar measurements in diabetes Lancet 1 1282-6
48. Haggard H W, Greenberg L A and Turner J M 1944 The physiological principles governing the action of acetone together with determination of toxicity J. Ind. Hyg. Toxicol. 26 133-51
49. Sigrist M W, Bartlome R, Marinov D, Rey J M, Vogler D E and Waechter H 2008 Trace gas monitoring with infrared laser-based detection schemes Appl. Phys. B 90 289-300
50. HITRAN 96 database Online at www.hitran.com
51. Parkes A M, Fawcett B L, Austin R E, Nakamichi S, Shallcross D E and Orr-Ewing A J 2003 Trace detection of volatile organic compounds by diode laser cavity ring-down spectroscopy Analyst 128 960-5
52. Cias P, Wang C and Dibble T S 2007 Absorption cross-sections of the C-H overtone of volatile organic compounds: 2 methyl-1,3-butadiene (isoprene), 1,3-butadiene, and 2,3-dimethyl-1,3-butadiene Appl. Spectrosc. 61 230-6
53. Scherrer S T, Wang C and Winstead C B 2005 Near infrared measurements of volatile organic compounds using diode laser cavity ringdown spectroscopy Proc. 60th Int. Symp. on Molecular, Spectroscopy (Columbus, OH, 20-24 June 2005)
54. Wang C, Srivastava N, Jones B A and Reese R B 2008 A novel multiple species ringdown spectrometer for in situ measurements of methane, carbon dioxide, and carbon isotope Appl. Phys. B 92 259-70
55. NIST Chemistry WebBook Acetone UV/VIS Spectrum; Acetone IR spectrum Online at http://webbook.nist.gov/chemistry
56. Keller-Rudek H and Moortgat G K 2007 MPI-Mainz-UV-VIS Spectral Atlas of Gaseous Molecules (Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.v.)
57. Cheng W H and Lee W J 1999 Technology development in breath microanalysis for clinical diagnosis J. Lab. Clin. Med. 133 218-28
58. Okabe H 1978 Photochemistry of Small Molecules (New York: Wiley)
59. Science-softCon uv/vis spectra data base Online at www.uv-spectra.de
60. Smith D, Spanel P and Davies S 1999 Trace gases in breath of healthy volunteers when fasting and after a protein-calorie meal: a preliminary study J. Appl. Physiol. 87 1584-8