Multistage modeling of leukemia in benzene workers: A simple approach to fitting the 2-stage clonal expansion model

American Journal of Epidemiology

Volumn 169, Issue 1, 2009, Pages 78-85

  Richardson, David B ^a  

^a IL   (United States)

Author keywords

Benzene; Leukemia; Models, statistical

Indexed keywords

BENZENE; CHLORIDE; RUBBER;

BENZENE; CLONAL GROWTH; DISEASE; EPIDEMIOLOGY; HEALTH RISK; MORTALITY; OCCUPATIONAL EXPOSURE; SOFTWARE; STATISTICAL ANALYSIS;

ADOLESCENT; ADULT; ARTICLE; CANCER RISK; CANCER STAGING; COHORT ANALYSIS; COMPUTER MODEL; COMPUTER PROGRAM; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DOSE TIME EFFECT RELATION; EMPLOYMENT STATUS; FOLLOW UP; HAZARD RATIO; HUMAN; INDUSTRIAL WORKER; LEUKEMIA; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL MODEL; MORTALITY; OBSERVATION; OCCUPATIONAL EXPOSURE; PUBLIC HEALTH; RUBBER INDUSTRY; STATISTICAL MODEL; TWO STAGE CLONAL EXPANSION MODEL;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; BENZENE; CHEMICAL INDUSTRY; COHORT STUDIES; HUMANS; LEUKEMIA; MALE; MIDDLE AGED; MODELS, STATISTICAL; OCCUPATIONAL EXPOSURE; OHIO; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; SOFTWARE; SURVIVAL RATE; TIME FACTORS;

EID: 58149269346     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kwn284     Document Type: Article

References (26)

1. Greenland S. Introduction to regression models. In: Rothman K, Greenland S, eds. Modern Epidemiology. 2nd ed. Philadelphia, PA: Lippincott-Raven; 1998.
2. Morrison AS. Sequential pathogenic components of rates. Am J Epidemiol. 1979;109(6):709-718.
3. Whittemore AS. The age distribution of human cancer for carcinogenic exposures of varying intensity. Am J Epidemiol. 1977;106(5):418-432.
4. Whittemore AS. Quantitative theories of oncogenesis. Adv Cancer Res. 1978;27:55-88.
5. Moolgavkar SH, Knudson AG Jr. Mutation and cancer: a model for human carcinogenesis. J Natl Cancer Inst. 1981;66(6):1037-1052.
6. Thomas DC. Models for exposure-time-response relationships with applications to cancer epidemiology. Annu Rev Public Health. 1988;9:451-482.
7. Nordling CO. A new theory on the cancer inducing mechanism. Br J Cancer. 1953;7(1):68-72.
8. Armitage P, Doll R. The age distribution of cancer and a multistage theory of carcinogenesis. Br J Cancer. 1954;8(1):1-12.
9. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100(1):57-70.
10. Armitage P, Doll R. A two-stage theory of carcinogenesis in relation to the age distribution of human cancer. Br J Cancer. 1957;11(2):161-169.
11. Frank SA. Dynamics of Cancer: Incidence, Inheritance, and Evolution. Princeton, NJ: Princeton University Press; 2007.
12. Heidenreich WF, Luebeck EG, Moolgavkar SH. Some properties of the hazard function of the two-mutation clonal expansion model. Risk Anal. 1997;17(3):391-399.
13. SAS Institute, Inc. SAS OnlineDoc 9.2. Cary, NC: SAS Institute, Inc; 2007.
14. Rinsky RA, Smith AB, Hornung R, et al. Benzene and leukemia: an epidemiologic risk assessment. N Engl J Med. 1987;316(17):1044-1050.
15. Rinsky RA, Hornung RW, Silver SR, et al. Benzene exposure and hematopoietic mortality: a long-term epidemiologic risk assessment. Am J Ind Med. 2002;42(6):474-480.
16. Moolgavkar SH, Luebeck EG, Krewski D, et al. Radon, cigarette smoke, and lung cancer: a re-analysis of the Colorado Plateau uranium miners' data. Epidemiology. 1993;4(3): 204-217.
17. Hazelton WD, Luebeck EG, Heidenreich WF, et al. Analysis of a historical cohort of Chinese tin miners with arsenic, radon, cigarette smoke, and pipe smoke exposures using the biologically based two-stage clonal expansion model. Radiat Res. 2001;156(1):78-94.
18. Haylock RG, Muirhead CR. Fitting the two-stage model of carcinogenesis to nested case-control data on the Colorado Plateau uranium miners: dependence on data assumptions. Radiat Environ Biophys. 2004;42(4):257-263.
19. Moolgavkar SH, Luebeck EG, Anderson EL. Estimation of unit risk for coke oven emissions. Risk Anal. 1998;18(6):813-825.
20. Knoke JD, Shanks TG, Vaughn JW, et al. Lung cancer mortality is related to age in addition to duration and intensity of cigarette smoking: an analysis of CPS-I data. Cancer Epidemiol Biomarkers Prev. 2004;13(6):949-957.
21. Meza R, Hazelton WD, Colditz GA, et al. Analysis of lung cancer incidence in the Nurses' Health and the Health Professionals' Follow-Up Studies using a multistage carcinogenesis model. Cancer Causes Control. 2008;19(3):317-328.
22. Lensing SY, Kodell RL. Fitting the two-stage clonal expansion model based on exact hazard to the ED01 data using SAS NLIN. Risk Anal. 1995;15(2):233-245.
23. Richardson D. Temporal variation in the association between benzene and leukemia mortality. Environ Health Perspect. 2008;116(3):370-374.
24. Cox LA Jr. Biological basis of chemical carcinogenesis: insights from benzene. Risk Anal. 1991;11(3):453-464.
25. Hazelton WD, Moolgavkar SH, Curtis SB, et al. Biologically based analysis of lung cancer incidence in a large Canadian occupational cohort with low-dose ionizing radiation exposure, and comparison with Japanese atomic bomb survivors. J Toxicol Environ Health A. 2006;69(11):1013-1038.
26. Luebeck EG, Heidenreich WF, Hazelton WD, et al. Biologically based analysis of the data for the Colorado uranium miners cohort: age, dose and dose-rate effects. Radiat Res. 1999;152(4):339-351.