Biologically based analysis of the data for the Colorado uranium miners cohort: Age, dose and dose-rate effects

Radiation Research

Volumn 152, Issue 4, 1999, Pages 339-351

  Luebeck, E Georg ^a   Heidenreich, Wolfgang F ^b   Hazelton, William D ^a   Paretzke, Herwig G ^b   Moolgavkar, Suresh H ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

RADON; URANIUM;

AGE; ARTICLE; CANCER EPIDEMIOLOGY; CANCER RISK; CIGARETTE SMOKING; DATA ANALYSIS; HUMAN; LUNG CANCER; MINER; OCCUPATIONAL CANCER; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; URANIUM MINE;

AGE FACTORS; AGED; AGED, 80 AND OVER; COCARCINOGENESIS; COHORT STUDIES; HUMANS; LIKELIHOOD FUNCTIONS; LUNG NEOPLASMS; MIDDLE AGED; MINING; MODELS, BIOLOGICAL; NEOPLASMS, RADIATION-INDUCED; OCCUPATIONAL EXPOSURE; RADIATION DOSAGE; SMOKING; URANIUM;

EID: 0032864112     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3580219     Document Type: Article

References (43)

1. National Research Council, Committee on the Biological Effects of Ionizing Radiation, Health Effects of Radon and Other Internally Deposited Alpha Emitters (BEIR IV). National Academy Press, Washington, DC, 1988.
2. J. M. Samet, Radon and lung cancer. J. Natl. Cancer Inst. 81, 745-757 (1989).
3. National Research Council, Committee on the Biological Effects of Ionizing Radiation, Health Effects of Exposure to Radon (BEIR VI). National Academy Press, Washington, DC, 1998.
4. J. H. Lubin, J. D. Boice, Jr., C. Edling, R. W. Hornung, G. Howe, E. Kunz, R. A. Kusiak, H. I. Morrison, E. P. Radford and D. A. Pierce, Lung Cancer and Radon: A Joint Analysis of 11 Underground Miners Studies. Publication No. 94-3644, U.S. National Institutes of Health, Bethesda, MD, 1994.
5. J. H. Lubin, J. D. Boice, Jr., C. Edling, R. W. Homung, G. Howe, E. Kunz, R. A. Kusiak, H. I. Morrison, E. P. Radford and S. X. Yao, Radon exposed underground miners and inverse exposure-rate (protraction enhancement) effects. Health Phys. 69, 494-500 (1995).
6. J. H. Lubin, J. D. Boice, Jr. and J. M. Samet, Errors in exposure assessment, statistical power and the interpretation of residential radon studies. Radiat. Res. 144, 329-341 (1995).
7. A. S. Whittemore and A. McMillan, Lung cancer mortality among U.S. uranium miners: A reappraisal. J. Natl. Cancer Inst. 71, 489-499 (1983).
8. D. C. Thomas, K. G. McNeill and C. Dougherty, Estimates of life-time lung cancer risks resulting from Rn progeny exposure. Health Phys. 49, 825-846 (1985).
9. R. W. Hornung and T. J. Meinhardt, Quantitative risk assessment of lung cancer in US uranium miners. Health Phys. 52, 417-430 (1987).
10. R. W. Hornung, J. A. Deddens and R. J. Roscoe, Modifiers of lung cancer risk in uranium miners from the Colorado plateau. Health Phys. 74, 12-21 (1998).
11. S. H. Moolgavkar and A. G. Knudson, Mutation and cancer: A model for human carcinogenesis. J. Natl. Cancer Inst. 66, 1037-1052 (1981).
12. S. H. Moolgavkar, Model for human carcinogenesis: Action of environmental agents. Environ. Health Perspect. 50, 285-291 (1983).
13. S. H. Moolgavkar and E. G. Luebeck, Two-event model for carcinogenesis: Biological, mathematical and statistical considerations. Risk Anal. 10, 323-341 (1990).
14. S. H. Moolgavkar, E. G. Luebeck, D. Krewski and J. M. Zielinski, Radon, cigarette smoke and lung cancer: A re-analysis of the Colorado Plateau uranium miners' data. Epidemiology 4, 204-217 (1993).
15. W. F. Heidenreich, On the parameters of the clonal expansion model. Radiat. Environ. Biophys. 35, 127-129 (1996).
16. W. F. Heidenreich, E. G. Luebeck and S. H. Moolgavkar, Some properties of the hazard function of the two-mutation clonal expansion model. Risk Anal. 17, 391-399 (1997).
17. International Classification of Diseases, 8th Revision (ICD 8). WHO, Geneva, 1967.
18. M. Kai, E. G. Luebeck and S. H. Moolgavkar, Analysis of the incidence of solid cancer among atomic bomb survivors using a two-stage model of carcinogenesis. Radiat. Res. 148, 348-358 (1997).
19. S. H. Moolgavkar, F. T. Cross, E. G. Luebeck and G. E. Dagle, A two-mutation model for radon-induced lung tumors in rats. Radiat. Res. 121, 28-37 (1990).
20. E. G. Luebeck, S. B. Curtis, F. T. Cross and S. H. Moolgavkar, Two-stage model of radon-induced malignant lung tumors in rats: Effects of cell killing. Radiat. Res. 145, 163-173 (1996).
21. A. Kopp-Schneider and C. J. Portier, Birth and death/differentiation rates of papillomas in mouse skin. Carcinogenesis 13, 973-978 (1992).
22. S. H. Moolgavkar and E. G. Luebeck, Multistage carcinogenesis: Population-based model for colon cancer. J. Natl. Cancer Inst. 84, 610-618 (1992).
23. S. H. Moolgavkar, E. G. Luebeck and E. L. Anderson, Estimation of unit risk for coke oven emissions. Risk Anal. 18, 813-825 (1998).
24. M. P. Little, Are two mutations sufficient to cause cancer? Some generalization to the two-mutation model of carcinogenesis of Moolgavkar, Venzon and Knudson, and of the multistage model of Armitage and Doll. Biometrics 51, 1278-1291 (1995).
25. M. P. Little, Generalization of the two-mutation and classical multistage models of carcinogenesis fitted to the Japanese atomic bomb survivor data. J. Radiol. Prot. 16, 7-24 (1996).
26. W. F. Heidenreich, P Jacob and H. G. Paretzke, Exact solutions of the clonal expansion model and their application to the incidence of solid tumors of atomic bomb survivors. Radiat. Environ. Biophys. 36, 45-58 (1997).
27. W. F. Heidenreich, P Jacob, H. G. Paretzke, F. T. Cross and G. E. Dagle, Two-step model for fatal and incidental lung tumor risk of rats exposed to radon. Radiat. Res. 151, 209-217 (1999).
28. H. H. Rossi and A. M. Kellerer, The dose rate dependence of oncogenic transformation by neutrons may be due to variation of response during the cell cycle. Int. J. Radiat. Biol. 50, 589-598 (1988). [letter to the Editor]
29. D. J. Brenner and E. J. Hall, The inverse dose rate effect for oncogenic transformation by neutrons and charged particles. A plausible interpretation consistent with published data. Int. Radiat. Biol. 58, 745-758 (1990).
30. D. G. Kendall, Birth-and-death processes, and the theory of carcinogenesis. Biometrika 47, 13-21 (1960).
31. J. Neyman and E. Scott, Statistical aspects of the problem of carcinogenesis. In Fifth Berkeley Symposium on Mathematical Statistics and Probability, pp. 55-77. University of California Press, Berkeley, 1967.
32. Q. Zheng, On the exact hazard and survival functions of the MVK stochastic carcinogenesis model. Risk Anal. 14, 1081-1084 (1994).
33. A. Kopp-Schneider, C. J. Portier and C. D. Sherman, The exact formula for tumor incidence in the two-stage model. Risk Anal. 14, 1079-1080 (1994).
34. J. Denes and D. Krewski, An exact representation for the generating function for the Moolgavkar-Venzon-Knudson two-stage model of carcinogenesis with stochastic stem cell growth. Math. Biosci. 131, 185-204 (1996).
35. W. R. Gilks, D. J. Spiegelhalter and S. Richardson, Practical Markov Chain Monte Carlo. Chapman and Hall, London, 1995.
36. R. Doll and R. Peto, Cigarette smoking and bronchial carcinoma: Dose and time relationships among regular smokers and life-long non-smokers. J. Epidemiol. Community Health 32, 303-313 (1978).
37. A. Spiethoff, H. Wesch, K. Wegener and H. J. Klimisch, The effects of Thorotrast and quartz on the induction of lung tumors in rats. Health Phys. 63, 101-110 (1992).
38. Y. Ishikawa, T. Mon, Y. Kato, E. Tsuchiya, R. Machinami, H. Sugano and T. Kitagawa, Lung cancers associated with Thorotrast exposure: High incidence of small-cell carcinoma and implications for estimation of radon risk. Int. J. Cancer 52, 570-574 (1992).
39. J. B. Little, Commentary: What are the risks of low-level exposure to α-particle radiation from radon? Proc. Natl. Acad. Sci. USA 94, 5996-5997 (1997).
40. S. H. Moolgavkar, Stochastic cancer models: Application to analyses of solid cancer incidence in the cohort of A-bomb survivors. Nucl. Energy 36, 447-451 (1997).
41. J. H. Lubin and J. D. Boice, Lung cancer risk from residential radon: Meta-analysis of eight epidemiological studies. J. Natl. Cancer Inst. 89, 49-57 (1997).
42. X-Z. Xuan, J. H. Lubin, J-L. Li, L-E Yang, L. Q. Sheng, Y. Lan, J-Z. Wang and W. J. Blot, A cohort study in Southern China of tin miners exposed to radon and radon decay products. Health Phys. 64, 120-131 (1993).
43. W. H. Press, B. P. Flammery, S. A. Teukolsky and W. T. Vetterling, Numerical Recipes: The Art of Scientific Computing. Cambridge University Press, Cambridge, 1986.