Poorly differentiated thyroid carcinoma: Diagnostic features and controversial issues

Endocrine Pathology

Volumn 19, Issue 3, 2008, Pages 150-155

  Volante, Marco ^a   Rapa, Ida ^a   Papotti, Mauro ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Carcinoma; Diagnosis; Insular; Poorly differentiated; Prognosis; Thyroid

Indexed keywords

ALGORITHM; CANCER CLASSIFICATION; CANCER GROWTH; CANCER MORPHOLOGY; CLINICAL FEATURE; HISTOGENESIS; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; REVIEW; THYROID CARCINOMA; CLASSIFICATION; METABOLISM; THYROID TUMOR;

HUMANS; IMMUNOHISTOCHEMISTRY; THYROID NEOPLASMS;

EID: 58149263559     PISSN: 10463976     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12022-008-9040-4     Document Type: Review

References (40)

1. A Sakamoto N Kasai H Sugano 1983 Poorly differentiated carcinoma of the thyroid. A clinicopathologic entity for a high-risk group of papillary and follicular carcinomas Cancer 52 1849 1855
2. F Cabanne R Gerard-Marchant R Heimann ED Williams 1974 Tumeurs malignes du corps thyroide. Problèmes de diagnostic histopathologique. A propos de 692 lèsions recuilles par le groupe coopèrateur de l'O.E.R.T.C Ann Anat Pathol 19 129 148
3. ML Carcangiu G Zampi J Rosai 1984 Poorly differentiated ("insular") thyroid carcinoma Am J Surg Pathol 8 655 668
4. S Pilotti P Collini L Mariani 1997 Insular carcinoma: a distinct de novo entity among follicular carcinomas of the thyroid gland Am J Surg Pathol 21 1466 1473
5. M Sobrinho-Simoes C Sambade E Fonseca P Soares 2002 Poorly differentiated carcinomas of the thyroid gland: a review of the clinicopathologic features of a series of 28 cases of a heterogeneous, clinically aggressive group of thyroid tumors Int J Surg Pathol 10 123 131
6. T Nishida S Katayama M Tsujimoto J Nakamura H Matsuda 1999 Clinicopathological significance of poorly differentiated thyroid carcinoma Am J Surg Pathol 23 205 211
7. O Ljungberg L Bondeson AG Bondeson 1984 Differentiated thyroid carcinoma, intermediate type: a new tumor entity with features of follicular and parafollicular cell carcinoma Hum Pathol 15 218 228
8. M Papotti F Botto Micca A Favero N Palestini G Bussolati 1993 Poorly differentiated thyroid carcinomas with primordial cell component. A group of aggressive lesions sharing insular, trabecular, and solid patterns Am J Surg Pathol 17 291 301
9. DP Byar SB Green P Dor ED Williams J Colon HA van Gilse M Mayer RJ Sylvester M van Glabbeke 1979 A prognostic index for thyroid carcinoma. A study of the E.O.R.T.C. Thyroid Cancer Cooperative Group Eur J Cancer 15 1033 1041
10. R Ashfaq F Vuitch R Delgado J Albores-Saavedra 1994 Papillary and follicular thyroid carcinomas with an insular component Cancer 73 416 423
11. M Sobrinho-Simões 1996 Poorly differentiated thyroid carcinomas Endocr Pathol 7 99 102
12. LA Akslen VA LiVolsi 2000 Poorly differentiated thyroid carcinoma-it is important Am J Surg Pathol 24 310 313
13. RH Nishiyama 1999 Another dissertation on poorly differentiated carcinomas: is it really necessary? Adv Anat Pathol 6 281 286
14. S Pilotti P Collini A Manzari E Marubini F Rilke 1995 Poorly differentiated forms of papillary thyroid carcinoma: distinctive entities or morphological patterns? Semin Diagn Pathol 12 249 255
15. DeLellis RA, LLoyd R, Heitz PU. WHO classification of tumors, pathology and genetics-tumors of endocrine organs. Lyon: IARC, 2004.
16. M Volante P Collini YE Nikiforov 2007 Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach Am J Surg Path 31 1256 1264
17. YE Nikiforov LA Erickson MN Nikiforova CM Caudill RV Lloyd 2001 Solid variant of papillary thyroid carcinoma: incidence, clinical-pathologic characteristics, molecular analysis, and biologic behavior Am J Surg Pathol 25 1478 1484
18. M Volante S Landolfi L Chiusa 2004 Poorly differentiated carcinomas of the thyroid with trabecular, insular and solid patterns. A clinico-pathological study of 183 cases Cancer 100 950 957
19. D Hiltzik DL Carlson RM Tuttle 2006 Poorly differentiated thyroid carcinomas defined on the basis of mitosis and necrosis: a clinicopathologic study of 58 patients Cancer 106 1286 1295
20. A Sasaki T Daa K Kashima S Yokoyama I Nakayama S Noguchi 1996 Insular component as a risk factor of thyroid carcinoma Pathol Int 46 939 946
21. V Rufini M Salvatori G Fadda 2007 Thyroid carcinomas with a variable insular component: prognostic significance of histopathologic patterns Cancer 110 1209 1217
22. M Papotti B Torchio L Grassi A Favero G Bussolati 1996 Poorly differentiated oxyphilic (Hurthle cell) carcinomas of the thyroid Am J Surg Pathol 20 686 694
23. JM Seoane J Cameselle-Teijeiro MA Romero 2002 Poorly differentiated oxyphilic (Hürthle cell) carcinoma arising in lingual thyroid: a case report and review of the literature Endocr Pathol 13 353 360
24. M Decaussin MH Bernard P Adeleine 2002 Thyroid carcinomas with distant metastases: a review of 111 cases with emphasis on the prognostic significance of an insular component Am J Surg Pathol 26 1007 1015
25. LA Akslen VA LiVolsi 2000 Prognostic significance of histologic grading compared with subclassification of papillary thyroid carcinoma Cancer 88 1902 1908
26. M Rivera RA Ghossein H Schoder D Gomez SM Larson RM Tuttle 2008 Histopathologic characterization of radioactive iodine-refractory fluorodeoxyglucose-positron emission tomography-positive thyroid carcinoma Cancer 113 1 48 56
27. JD Lin TC Chao C Hsueh 2007 Clinical characteristics of poorly differentiated thyroid carcinomas compared with those of classical papillary thyroid carcinomas Clin Endocrinol (Oxf) 66 224 228
28. TS Jung TY Kim KW Kim 2007 Clinical features and prognostic factors for survival in patients with poorly differentiated thyroid carcinoma and comparison to the patients with the aggressive variants of papillary thyroid carcinoma Endocr J 54 265 274
29. EM Sanders Jr VA LiVolsi J Brierley J Shin GW Randolph 2007 An evidence-based review of poorly differentiated thyroid cancer World J Surg 31 934 945
30. M Pulcrano H Boukheris M Talbot 2007 Poorly differentiated follicular thyroid carcinoma: prognostic factors and relevance of histological classification Thyroid 17 639 646
31. G Tallini G Garcia-Rostan A Herrero 1999 Downregulation of p27KIP1 and Ki67/Mib1 labeling index support the classification of thyroid carcinoma into prognostically relevant categories Am J Surg Pathol 23 678 685
32. Y Dobashi H Sugimura A Sakamoto 1994 Stepwise participation of p53 gene mutation during dedifferentiation of human thyroid carcinomas Diagn Mol Pathol 3 9 14
33. R Donghi A Longoni S Pilotti P Michieli G Della Porta MA Pierotti 1993 Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland J Clin Invest 91 1753 1760
34. F Basolo F Pisaturo LE Pollina 2000 N-ras mutation in poorly differentiated thyroid carcinomas: correlation with bone metastases and inverse correlation to thyroglobulin expression Thyroid 10 19 23
35. G Garcia-Rostan H Zhao RL Camp 2003 Ras mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancer J Clin Oncol 21 3226 3235
36. AS Rocha P Soares E Fonseca J Cameselle-Teijeiro MC Oliveira M Sobrinho-Simões 2003 E-cadherin loss rather than beta-catenin alterations is a common feature of poorly differentiated thyroid carcinomas Histopathology 42 580 587
37. G Garcia-Rostan RL Camp A Herrero ML Carcangiu DL Rimm G Tallini 2001 Beta-catenin dysregulation in thyroid neoplasms: down-regulation, aberrant nuclear expression, and CTNNB1 exon 3 mutations are markers for aggressive tumor phenotypes and poor prognosis Am J Pathol 158 987 996
38. MN Nikiforova ET Kimura M Gandhi 2003 BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas J Clin Endocrinol Metab 88 5399 5404
39. P Soares V Trovisco AS Rocha 2004 BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas Virchows Arch 444 572 576
40. M Santoro M Papotti G Chiappetta 2002 RET activation and clinicopathologic features in poorly differentiated thyroid tumors J Clin Endocrinol Metab 87 370 379