Evaluation of a critical process parameter: Oxygen limitation during cultivation has a fully reversible effect on gene expression of Bordetella pertussis

Biotechnology and Bioengineering

Volumn 102, Issue 1, 2009, Pages 161-167

  Streefland, Mathieu ^a   Van de Waterbeemd, Bas D ^a   Kint, Joeri ^a,b   Van Der Pol, Leo A ^a   Beuvery, E Coen ^c   Tramper, Johannes ^b   Martens, Dirk E ^b  

^a NETHERLANDS VACCINE INSTITUTE   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c PAT Consultancy ^*  (Netherlands)

Author keywords

Biopharmaceutical; Bordetella pertussis; Cultivation; Dissolved oxygen concentration; DNA microarray; Oxygen limitation; PAT; Process analytical technology; Vaccine; Virulence

Indexed keywords

BIOPHARMACEUTICAL; BORDETELLA PERTUSSIS; DISSOLVED OXYGEN CONCENTRATION; DNA MICROARRAY; OXYGEN LIMITATION; PAT; PROCESS ANALYTICAL TECHNOLOGY; VACCINE; VIRULENCE;

BIOACTIVITY; CHEMICAL SENSORS; CULTIVATION; DISSOLUTION; DISSOLVED OXYGEN SENSORS; DNA; DRUG PRODUCTS PLANTS; GENE EXPRESSION; GENES; NONMETALS; NUCLEIC ACIDS; ORGANIC ACIDS; OXYGEN; RISK ASSESSMENT; RISK MANAGEMENT; VACCINES;

DISSOLVED OXYGEN;

DISSOLVED OXYGEN; OXYGEN;

ARTICLE; BACTERIAL GENE; BACTERIUM CULTURE; BORDETELLA PERTUSSIS; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION; GENE IDENTIFICATION; NONHUMAN; PROCESS CONTROL; PROCESS DEVELOPMENT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGY;

BACTERIA (MICROORGANISMS); BORDETELLA PERTUSSIS;

BORDETELLA PERTUSSIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXYGEN;

EID: 58149243119     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22030     Document Type: Article

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