Cardiac morbidity and mortality after breast conservation treatment in patients with early-stage breast cancer and preexisting cardiac disease

Clinical Breast Cancer

Volumn 8, Issue 5, 2008, Pages 443-448

  Gutt, Ruchika ^a   Correa, Candace ^a   Hwang, Wei Ting ^a   Solin, Lawrence ^a   Litt, Harold ^a   Ferrari, Victor ^a   Harris, Eleanor ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Ischemic heart disease; Myocardial infarction; Radiation therapy

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOXORUBICIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER RADIOTHERAPY; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONGESTIVE HEART FAILURE; CONSERVATIVE TREATMENT; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HEART DEATH; HEART DISEASE; HEART INFARCTION; HUMAN; INCIDENCE; MEGAVOLTAGE RADIOTHERAPY; MORBIDITY; MORTALITY; OVERALL SURVIVAL; RADIATION DOSE; RISK FACTOR; SURVIVAL RATE; TUMOR LOCALIZATION; TUMOR VOLUME; ADJUVANT THERAPY; BREAST TUMOR; HEART; HEMISPHERIC DOMINANCE; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; RADIATION EXPOSURE; SEGMENTAL MASTECTOMY;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; COMBINED MODALITY THERAPY; FEMALE; FUNCTIONAL LATERALITY; HEART; HEART DISEASES; HUMANS; MASTECTOMY, SEGMENTAL; MIDDLE AGED; RADIOTHERAPY, ADJUVANT;

EID: 58149232645     PISSN: 15268209     EISSN: None     Source Type: Journal    
DOI: 10.3816/CBC.2008.n.054     Document Type: Article

References (33)

1. Liljegren G, Holmberg L, Bergh J, et al. 10-Year results after sector resection with or without postoperative radiotherapy for stage I breast cancer: A randomized trial. J Clin Oncol 1999; 17:2326-33.
2. Veronesi U, Marubini E, Mariani L, et al. Radiotherapy after breast-conserving surgery in small breast carcinoma: Long-term results of a randomized trial. Ann Oncol 2001; 12:997-1003.
3. Clark RM, Whelan T, Levine M, et al. Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer: An update. Ontario Clinical Oncology Group. J Natl Cancer Inst 1996; 88:1659-64.
4. Forrest AP, Stewart HJ, Everington D, et al. Randomised controlled trial of conservation therapy for breast cancer: 6-Year analysis of the Scottish trial. Scottish Cancer Trials Breast Group. Lancet 1996; 348:708-13.
5. Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002; 347:1233-41.
6. Early Breast Cancer Trialists' Collaborative Group. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of randomized trials. Lancet 2005; 366: 2087-106.
7. van Dongen JA, Voogd AC, Fentiman IS, et al. Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst 2002; 92:1143-50.
8. Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002; 347:1227-32.
9. Paszat LF, Mackillop WJ, Groome PA, et al. Mortality from myocardial infarction after adjuvant radiotherapy for breast cancer in the surveillance, epidemiology, and end-results cancer registries. J Clin Oncol 1998; 16:2625-31.
10. Rutqvist LE, Lax I, Fornander T, et al. Cardiovascular mortality in a randomized trial of adjuvant radiation therapy versus surgery alone in primary breast cancer. Int J Radiat Oncol Biol Phys 1992; 22:887-96.
11. Paszat LF, Mackillop WJ, Groome PA, et al. Mortality from myocardial infarction following postlumpectomy radiotherapy for breast cancer: a population-based study in Ontario, Canada. Int J Radiat Oncol Biol Phys 1999; 43:755-62.
12. Gyenes G, Gagliardi G, Lax I, et al. Evaluation of irradiated heart volumes in stage I breast cancer patients treated with postoperative adjuvant radiotherapy. J Clin Oncol 1997; 15:1348-53.
13. Cuzick J, Stewart H, Rutqvist L, et al. Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy. J Clin Oncol 1994; 12:447-53.
14. Overgaard M, Bentzen SM, Christensen JJ, et al. The value of the NSD formula in equation of acute and late radiation complications in normal tissue following 2 and 5 fractions per week in breast cancer patients treated with postmastectomy irradiation. Radiother Oncol 1987; 9:1-11.
15. Fuller SA, Haybittle JL, Smith RE, et al. Cardiac doses in post-operative breast irradiation. Radiother Oncol 1992; 25:19-24.
16. Marks LB, Hebert ME, Bentel G, et al. To treat or not to treat the internal mammary nodes: a possible compromise. Int J Radiat Oncol Biol Phys 1994; 29:903-9.
17. Pierce LJ, Griffith KA, Hayman JA, et al. Conservative surgery and radiotherapy for stage I/II breast cancer using lung density correction: 10-year and 15-year results. Int J Radiat Oncol Biol Phys 2005; 61:1317-27.
18. Harris EE, Correa C, Hwang WT, et al. Late cardiac mortality and morbidity in early stage breast cancer patients after breast conservation treatment. J Clin Oncol 2006; 24:4100-6.
19. American Joint Committee on Cancer. Cancer Staging Manual. 5th edition. New York: Springer; 2002.
20. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53:457-81.
21. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies. J Natl Cancer Inst 1959; 22:719-48.
22. Lunn M, McNeil D. Applying Cox regression to competing risks. Biometrics 1995; 51:524-32.
23. Kalbfleisch JD, Prentice RL. The Statistical Analysis of Failure Time Data. 2nd edition. New York: Wiley; 2002.
24. Giordano SH, Kuo YF, Freeman JL, et al. Risk of Cardiac Death after Adjuvant Radiotherapy for Breast Cancer. J Natl Cancer Inst 2005; 97:419-24.
25. Nixon AJ, Manola J, Gelman R, et al. No long-term increase in cardiac-related mortality after breast-conserving surgery and radiation therapy using modern techniques. J Clin Oncol 1998; 16:1374-9.
26. Marks LB, Yu X, Prosnitz RG, et al. The Incidence and Functional Consequences of RT-associated cardiac perfusion defects. Int J Radiat Oncol Biol Phys 2005; 63:214-23.
27. Hooning MJ, Botma A, Aleman BM, et al. Long-term risk of cardiovascular disease in long-term survivors of breast cancer. Int J Radiat Oncol Biol Phys 2007; 99:365-75.
28. Darby S, Ewertz M, Hall P, et al. Previous heart disease and risk of radiationinduced heart disease in women with early breast cancer. Presented at: the 29th San Antonio Breast Cancer Symposium; December 14-17, 2006; San Antonio, TX. Abstract 4085.
29. Fisher B, Bryant J, Dignam JJ, et al. National Surgical Adjuvant Breast and BowelProject. Tamoxifen, radiation therapy, or both for prevention of ipsilateral breast tumor recurrence after lumpectomy in women with invasive breast cancers of one centimeter or less. J Clin Oncol 2002; 20:4141-9.
30. Hughes KS, Schnaper LA, Berry D, et al. Cancer and Leukemia Group B; Radiation Therapy Oncology Group; Eastern Cooperative Oncology Group. Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer. N Engl J Med 2004; 351:971-7.
31. Fyles AW, McCready DR, Manchul LA, et al. Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer. N Engl J Med 2004; 351:963-70.
32. Landau D, Adams EJ, Webb S, et al. Cardiac avoidance in breast radiotherapy: a comparison of simple shielding techniques with intensity-modulated radiotherapy. Radiother Oncol 2001; 60:247-55.
33. Korreman SS, Pedersen AN, Nottrup TJ, et al. Breathing adapted radiotherapy for breast cancer: comparison of free breathing gating with the breath-hold technique. Radiother Oncol 2005; 76:311-8.