The mycotoxin patulin, modulates tight junctions in caco-2 cells

Toxicology in Vitro

Volumn 23, Issue 1, 2009, Pages 83-89

  McLaughlin, John ^a   Lambert, Daniel ^a   Padfield, Philip J ^a   Burt, Julian P H ^b   O'Neill, Catherine A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b BANGOR UNIVERSITY   (United Kingdom)

Author keywords

Claudin; Mycotoxin; Occludin; Paracellular permeability; Patulin; Tight junction; ZO 1

Indexed keywords

CLAUDIN; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; MYCOTOXIN; OCCLUDIN; PATULIN; PROTEIN ZO1;

ARTICLE; CELL LINE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ELECTRIC RESISTANCE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INTESTINE CELL; MOLECULAR WEIGHT; MONOLAYER CULTURE; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; TIGHT JUNCTION;

CACO-2 CELLS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC IMPEDANCE; ENZYME INHIBITORS; HUMANS; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; PATULIN; PHENANTHROLINES; PHOSPHOPROTEINS; POISONS; TIGHT JUNCTIONS; ZINC SULFATE;

EID: 58149178595     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.10.009     Document Type: Article

References (37)

1. Antonetti D.A., Barber A.J., Hollinger L.A., Wolpert E.B., and Gardner T.W. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occludens 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumours. Journal of Biological Chemistry 274 (1999) 23463-23467
2. Andreeva A.Y., Krause E., Muller E.C., Blasig I.E., and Utepbergenov I. Protein kinase C regulates the phosphorylation and cellular localisation of occludin. Journal of Biological Chemistry 237 (2001) 38480-38486
3. Arafat W., and Musa M.N. Patulin-induced inhibition of protein synthesis in hepatoma tissue culture. Research Communications in Molecular Pathology and Pharmacology 87 (1995) 177-186
4. Arafat W., Kern D., and Dirheimer G. Inhibition of aminoacyl-tRNA synthetases by the mycotoxin patulin. Chemical and Biological Interactions 56 (1985) 333-349
5. Balda M.S., Whitney J.A., Flores C., Gonzales S., Cereijido M., and Matter K. Functional dissociation of paracellular permeability and transepithelial resistance and disruption of the apical basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. Journal of Cell Biology 134 4 (1996) 1031-1049
6. Balda M.S., Flores-Maldonado C., Cereijido M., and Matter K. Multiple domains of occluding are involved in the regulation of paracellular permeability. Journal of Cellular Biochemistry 78 1 (2000) 85-96
7. Burda K. Incidence of patulin in apple, pear and mixed fruit products marketed in new South Wales. Journal of Food Protection 55 (1992) 796-798
8. Chen Y., Lu Q., Schneeberger E.E., and Goddenough D.A. Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed madin-darby canine kidney cells. Molecular Biology of the Cell 11 (2000) 849-862
9. Ciegler A., Detroy R., and Lillehoj E.B. Patulin, penicillinic acid and other carcinogenic lactones. In: Ciegler A., Kadis S., and Ajl S.J. (Eds). Fungal Toxins (1971), Academic Press, New York 409-434
10. Gonzalez-Osnaya L., Soriano J.M., Molto J.C., and Manes J. Exposure to patulin from consumption of apple-based products. Food Additives and Contaminants 24 (1971) 1268-1274
11. Gonzalez-Osnaya L., Soriano J.M., Molto J.C., and Manes J. Exposure to patulin from consumption of apple-based products. Food Additives and Contaminants 24 11 (2007) 1268-1274
12. Guo X., Rao J.N., Liu L., Zou T., Keledjian K.M., Boneva D., Marasa B.S., and Wang J.Y. Polyamines are necessary for synthesis and stability of occluding protein in intestinal epithelial cells. American Journal of Physiology (Gastrointestinal and Liver) 288 (2005) G1159-G1169
13. Halvorsen B., Staff A.C., Ligaarden S., Prydz K., and Kolset S.O. Lithocholic acid and sulphated lithocholic acid differ in the ability to promote matrix metalloproteinase secretion in the human colon cancer cell linemcaco-2. Biochemical Journal 349 (2000) 189-193
14. Lafont P., Siriwardana M.G., and DeBoer E. Contamination of dairy products by fungal metabolites. Journal of Environmental Pathology, Toxicology and Oncology 10 (1990) 99-102
15. Lambert D., Padfield P., McLaughlin J., Cannell S., and O'Neill C.A. Ochratoxin a displaces claudins from detergent resistant membrane microdomains. Biochemical and Biophysical Research Communications 358 (2007) 632-636
16. Lambert D., O'Neill C.A., and Padfield P.J. Depletion of caco-2 cell cholesterol disrupts barrier function by altering the detergent solubility and distribution of specific tight junction proteins. Biochemical Journal 387 (2005) 553-560
17. Leroy A., Lauwalt T., DeBruyne G., Cornelissan M., and Mareel M. Entamoeba Histolyca disturbs the tight junction complex in human enteric T84 cell layers. FASEB Journal 14 (2000) 1139-1146
18. Lohmann C., Krischke M., Wegener J., and Galla H.J. Tyrosine phosphatise inhibition induces loss of blood-brain barrier integrity by matrix metalloproteinase-dependent and independent pathways. Brain Research 9 (2004) 184-196
19. Lopez-Diaz T.M., Roam-Blanco C., Garcia-Arias M.T., Garcia-Fernandez M.C., and Garcia-Lopez M.L. Mycotoxins in two Spanish cheese varieties. International Journal of Food Microbiology 30 (1996) 391-395
20. Lopez-Diaz T.M., and Flannigan B. Production of patulin and cytochalasin E by Aspergillus clavatus during malting of barley and wheat. International Journal of Food Microbiology 35 (1997) 129-136
21. Mahfoud R., Maresca M., Garmy N., and Fantini J. The mycotoxin patulin alters the barrier function of the intestinal epithelium: mechanism of action of the toxin and protective effects of glutathione. Toxicology and Applied Pharmacology. 181 (2002) 209-218
22. McKinley E.R., and Carlton W.W. Patulin mycotoxicosis in swiss ICR mice. Food Chemistry and Toxicology 18 (1980) 181-187
23. McKinley E.R., and Carlton W.W. Patulin mycotoxicosis in Syrian Hamster. Food Chemistry and Toxicology 18 (1980) 173-179
24. McKinley E.R., Carlton W.W., and Boon G.D. Patulin mycotoxicosis in the rat: toxicology, pathology and clinical pathology. Food Chemistry and Toxicology 20 3 (1982) 289-300
25. McLaughlin J., Padfield P., Burt J.P.H., and O'Neill C.A. Ochratoxin a increases permeability through tight junctions by removal of specific claudin isoforms. American Journal of Physiology (Cell Physiology) 287 (2004) C1412-1417
26. Miura S., Hasumi K., and Endo A. Inhibition of protein prenylation by patulin. FEBS Letters 318 (1993) 88-90
27. Pfeiffer E., Gross K., and Metzler M. Aneuploidogenic and clastogenic potential of the mycotoxins citrinin and patulin. Carcinogenesis 19 (1998) 1313-1318
28. Piemontese L., Solfrizzo M., and Visconti A. Occurrence of patulin in conventional and organic fruit products in Italy and subsequent exposure assessment. Food Additives and Contaminants 22 (2005) 437-442
29. Riley R.T., and Showker J.L. The mechanism of patulin's cytotoxicity and the antioxidant activity of indole tetramic acids. Toxicology and Applied Pharmacology 109 (1991) 108-126
30. Ritieni A. Patulin in Italian commercial apple products. Journal of Agricultural Food Chemistry 51 (2003) 6086-6090
31. Roll R., Matthiaschk G., and Korte A. Embryotoxicity and mutagenicity of mycotoxins. Journal of Environmental Pathology, Toxicology and Oncology 10 (1990) 1-7
32. Speijers G.J., Franken M.A., and Van Leeuwen F.X. Subacute toxicity study of patulin in the rat: effects on the kidney and the gastrointestinal tract. Food Chemistry and Toxicology 26 1 (1988) 23-30
33. VanItallie C.M., and Anderson J.M. Claudins and epithelial paracellular transport. Annual Review in Physiology 68 (2006) 403-429
34. Van Itallie C., Balda M.S., and Anderson J.M. Epidermal growth factor induces tyrosine phosphorylation and reorganisation of the tight junction protein ZO-1 in A431 cells. Journal of Cell Science 108 (1995) 1735-1742
35. Van Itallie C.M., Colegio O.R., and Anderson J.M. The cytoplasmic tails of claudins can influence tight junction barrier properties through effects on protein stability. Journal of Membrane Biology 199 (2004) 29-38
36. Wachtel M., Frei K., Fintanna A., Winterhalter K., and Gloor S.M. Occludin proteolysis and increased permeability in endothelial cells through tyrosine phosphatase inhibition. Journal of Cell Science 112 (1999) 4347-4356
37. Wong X., Wong B., Wright S.D., and Cai T.Q. Production of matrix metalloproteinase-9 in caco-2 cells in response to inflammatory stimuli. Journal of Interferon and Cytokine Research 21 (2001) 93-98