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3+-catalyzed manner. (a) Loh, T.-P.; Tan, K.-T.; Hu, Q.-Y Tetrahedron Lett. 2001, 42, 8705.
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A conceptually unique but related strategy called cascade catalysis refers to the use of several different catalysts in one-pot procedures to catalyze mechanistically distinct steps of a cascade reaction. The approach presented here is fundamentally different but could, in theory, be used in combination with cascade catalysis
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A conceptually unique but related strategy called cascade catalysis refers to the use of several different catalysts in one-pot procedures to catalyze mechanistically distinct steps of a cascade reaction. The approach presented here is fundamentally different but could, in theory, be used in combination with cascade catalysis.
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While this work was in progress, Banik reported an optimized procedure. See: Org. Synth. 2005, 81, 188
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While this work was in progress, Banik reported an optimized procedure. See: Org. Synth. 2005, 81, 188.
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0 or NaOTf, <5% product was detected, even after 24 h.
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61349142759
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Aldehydes tested include propionaldehyde, 2-methylpropionaldehyde, cyclohexanecarboxaldehyde, and pivaldehyde
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Aldehydes tested include propionaldehyde, 2-methylpropionaldehyde, cyclohexanecarboxaldehyde, and pivaldehyde.
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0002980424
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Authentic samples of m- and p-methoxyphenyl products 1h were used in these experiments. Each of the three isomers (o-, m-, and p-substituted 1h) were treated with 1-8 equiv of CAN in MeCN/water or MeOH/water at temperatures ranging from -12 °C to rt, under an atmosphere of nitrogen, and also in air. All reactions afforded intractible mixtures containing a poor yield of the desired product. For leading references on N-dearylation, see: (a) Sakai, T.; Yan, F.; Uneyama, K. Synlett 1995, 753.
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Authentic samples of m- and p-methoxyphenyl products 1h were used in these experiments. Each of the three isomers (o-, m-, and p-substituted 1h) were treated with 1-8 equiv of CAN in MeCN/water or MeOH/water at temperatures ranging from -12 °C to rt, under an atmosphere of nitrogen, and also in air. All reactions afforded intractible mixtures containing a poor yield of the desired product. For leading references on N-dearylation, see: (a) Sakai, T.; Yan, F.; Uneyama, K. Synlett 1995, 753.
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1H NMR spctroscopy) in these reactions.
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