Carnosol delays chemotherapy-induced DNA fragmentation and morphological changes associated with apoptosis in leukemic cells

Nutrition and Cancer

Volumn 61, Issue 1, 2009, Pages 94-102

  Zunino, Susan J ^a   Storms, David H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARNOSOL; CASPASE 3; CYTARABINE; DNA; DNA NUCLEOTIDYLEXOTRANSFERASE; METHOTREXATE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELL DEATH; CELL LABELING; CELL MEMBRANE DEPOLARIZATION; CELL STRAIN RS4;11; CELL STRAIN SEM; CONTROLLED STUDY; DIETARY INTAKE; DNA CLEAVAGE; DNA FRAGMENTATION; DNA STRAND BREAKAGE; DRUG EFFICACY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE; MONOTHERAPY; PHENOTYPE; ROSEMARY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; DITERPENES, ABIETANE; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MITOCHONDRIAL MEMBRANES; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

ROSMARINUS OFFICINALIS;

EID: 58149173326     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1080/01635580802357360     Document Type: Article

References (39)

1. Singletary K, MacDonald C, and Wallig M: Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett 104, 43-48, 1996.
2. Huang M-T, Ho C-T, Yuan Wang Z, Ferraro T, Lou Y-R, et al.: Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Cancer Res 54, 701-708, 1994.
3. Moran AD, Carothers AM, Weyant MJ, Redston M, and Bertagnolli MM: Carnosol inhibits beta-catenin tyrosine phosphorylation and prevents adenoma formation in the C57BL/6J/Min/+ (Min/+) mouse. Cancer Res 65, 1097-1104, 2005.
4. Huang SC, Ho CT, Lin-Shau SY, and Lin JK: Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kappa B and c-Jun. Biochem Pharmacol 69, 221-232, 2005.
5. Dörrie J, Sapala K, and Zunino SJ: Carnosol-induced apoptosis and downregulation of Bcl-2 in B-lineage leukemia cells. Cancer Lett 170, 33-39, 2001.
6. Faderl S, Kantarjian HM, Talpaz M, and Estrov Z: Clinical significance of cytogenetic abnormalities in adult acute lymphoblastic leukemia. Blood 91, 3995-4019, 1998.
7. Greaves MF and Wiemels J: Origins of chromosome translocations in childhood leukemia. Nature Rev 3, 1-11, 2003.
8. Nachman JB, Sather HN, Sensel MG, Trigg ME, Cherlow JM, et al.: Augmented post-induction therapy for children with high-risk acute lymphoblastic leukemia and a slow response to initial therapy. N Engl J Med 338, 1663-1671, 1998.
9. Garg AK, Buchholz TA, and Aggarwal BB: Chemosensitization and radiosensitization of tumors by plant polyphenols. Antioxid Redox Signal 7, 1630-1647, 2005.
10. Fulda S and Debatin KM: Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol. Oncogene 23, 6702-6711, 2004.
11. Ahmad KA, Clement MV, Hanif IM, and Pervaiz S: Resveratrol inhibits drug-induced apoptosis in human leukemia cells by creating an intracellular milieu nonpermissive for death execution. Cancer Res 64, 1452-1459, 2004.
12. Venkatesan N, Punithavathi D, and Arumugam V: Curcumin prevents adriamycin nephrotoxicity in rats. Br J Pharmacol 129, 231-234, 2000.
13. Venkatesan N: Curcumin attenuation of acute adriamycin myocardial toxicity in rats. Br J Pharmacol 124, 425-427, 1998.
14. Chlopcikova S, Psotova J, Miketova P, and Simanek V: Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes: Part I. silymarin and its flavonolignans. Phytother Res 18, 107-110, 2004.
15. Greil J, Gramatzki M, Burger R, Marschalek R, Peltner M, et al.: The acute lymphoblastic leukemia cell line SEM with t(4;11) chromosomal rearrangement is biphenotypic and responsive to interleukin-7. Br J Haematol 86, 275-283, 1994.
16. Stong RC, Korsmeyer SJ, Parkin JL, Arthur DC, and Kersey JH: Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics. Blood 65, 21-31, 1985.
17. Dörrie J, Gerauer H, Wachter Y, and Zunino SJ: Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res 61, 4731-4739, 2001.
18. Dive C, Gregory CD, Phipps DJ, Evans DL, Milner AE, et al.: Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry. Biochem Biophys Acta 1133, 275-285, 1992.
19. Darzynkiewicz Z, Bruno S, Del Bino G, Gorczyca W, Hotz MA, et al.: Features of apoptotic cells measured by flow cytometry. Cytometry 13, 795-808, 1992.
20. Green DR and Reed JC: Mitochondria and apoptosis. Science 81, 1309-1312, 1998.
21. Earnshaw WC, Martins LM, and Kaufmann SH: Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 68, 383-424, 1999.
22. Wyllie AH: Cell death: the significance of apoptosis. Int Rev Cytol 68, 251-305, 1980.
23. Brown DG, Sun X-M, and Cohen GM: Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation. J Biol Chem 268, 3037-3039, 1993.
24. Sun X-M and Cohen GM: Mg2+-dependent cleavage of DNA into kilobase pair fragments is responsible for the initial degradation of DNA in apoptosis. J Biol Chem 269, 14857-14860, 1994.
25. Widlak P and Garrard WT: Discovery, regulation, and action of the major apoptotic nucleases DFF40/CAD and endonuclease G. J Cell Biochem 94, 1078-1087, 2005.
26. Wang X, Yang C, Chai J, Shi Y, and Xue D: Mechanism of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans. Science 298, 1587-1592, 2002.
27. Duriez PJ and Shah GM: Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death. Biochem Cell Biol 75, 337-349, 1997.
28. Flygare J, Hellgren D, and Wennborg A: Caspase-3 mediated cleavage of HsRad51 at an unconventional site. Eur J Biochem 267, 5977-5982, 2000.
29. Chen F, Arseven OK, and Cryns VL: Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis. J Biol Chem 279, 27542-27548, 2004.
30. Smith GCM, d'Adda di Fagagna F, Lakin ND, and Jackson SP: Cleavage and inactivation of ATM during apoptosis. Mol Cell Biol 19, 6076-6084, 1999.
31. Sikora E, Bielak-Zmijewska A, Magalska A, Piwocka K, Mosieniak G, et al.: Curcumin induces caspase-3-dependent apoptotic pathway but inhibits DNA fragmentation factor 40/caspase-activated DNase endonuclease in human Jurkat cells. Mol Cancer Ther 5, 927-934, 2006.
32. Jänicke RU, Sprengart ML, Wati MR, and Porter AG: Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 273, 9357-9360, 1998.
33. Woo M, Hakem R, Soengas MS, Duncan GS, Shahinian A, et al.: Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear antigens. Genes Dev 12, 806-819, 1998.
34. Jänicke RU, Ng P, Sprengart ML, and Porter AG: Caspase-3 is required for a-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis. J Biol Chem 273, 15540-15545, 1998.
35. Fischer U, Jänicke RU, and Schulze-Osthoff K: Many cuts to ruin: a comprehensive update of caspase substrates. Cell Death Differ 10, 76-100, 2003.
36. Aggarwal BB and Shishodia S: Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71, 1397-1421, 2006.
37. Aoyagi Y, Takahashi Y, Satake Y, Takeya K, Aiyama R, et al.: Cytotoxicity of abietane diterpenoids from Perovskia abrotanoides and of their semisynthetic analogues. Bioorg Med Chem 14, 5285-5291, 2006.
38. Perez-Fons L, Aranda FJ, Guillen J, Villalain J, and Micol V: Rosemary (Rosmarinus officinalis) diterpenes affect lipid polymorphism and fluidity in phopholipid membranes. Arch Biochem Biophys 453, 224-236, 2006.
39. Subbaramaiah K, Cole PA, and Dannenberg AJ: Retinoids and carnosol suppress cyclooxygenase-2 transcription by CREB-binding protein/p300-dependent and -independent mechanisms. Cancer Res 62, 2522-2530, 2002.