Genetic ablation of CD36 induces age-related corneal neovascularization

Cornea

Volumn 27, Issue 9, 2008, Pages 1037-1041

  Mwaikambo, Bupe R ^a,b   Sennlaub, Florian ^c   Ong, Huy ^d   Chemtob, Sylvain ^a,b   Hardy, Pierre ^b  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF MONTREAL   (Canada)

^c INSERM   (France)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Angiogenic privilege; CD36; Corneal avascularity; Corneal neovascularization

Indexed keywords

ANGIOGENIC FACTOR; CD36 ANTIGEN; MESSENGER RNA; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE 1; THROMBOSPONDIN 1; VASCULOTROPIN A; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CORNEA; CORNEA NEOVASCULARIZATION; DENSITY; DISEASE SEVERITY; GENETIC ABLATION; GENETIC PROCEDURES; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WILD TYPE; AGING; ANIMAL; BLOOD VESSEL; C57BL MOUSE; CORNEA OPACITY; DOWN REGULATION; GENE DELETION; GENETICS; METABOLISM; MOUSE MUTANT; PATHOLOGY; VASCULARIZATION;

AGING; ANIMALS; ANTIGENS, CD36; BLOOD VESSELS; CORNEA; CORNEAL NEOVASCULARIZATION; CORNEAL OPACITY; DOWN-REGULATION; GENE DELETION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 8; PROTO-ONCOGENE PROTEINS C-JUN; RNA, MESSENGER; THROMBOSPONDIN 1; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 58149161930     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/ICO.0b013e31817780b6     Document Type: Article

References (18)

1. Chang JH, Gabison EE, Kato T, et al. Corneal neovascularization. Curr Opin Ophthalmol. 2001;12:242-249.
2. Lee P, Wang C, Adamis A. Ocular neovascularization: an epidemiologic review. Surv Ophthalmol. 1998;43:245-269.
3. Whitcher JP, Srinivasan M, Upadhyay MP. Corneal blindness: a global perspective. Bull World Health Organ. 2001;79:214-221.
4. Zhang G, Dass CR, Sumithran E, et al. Effects of deoxyribozymes targeting cJun on solid tumor growth and angiogenesis in rodents. J Natl Cancer Inst. 2004;96:683-696.
5. Mwaikambo B, Sennlaub F, Ong H, et al. Activation of CD36 inhibits and induces regression of inflammatory corneal neovascularization. Invest Ophthalmol Vis Sci. 2006;47:4356-4364.
6. Ambati B, Nozaki M, Singh N, et al. Corneal avascularity is due to soluble VEGF receptor-1. Nature. 2006;443:993-997.
7. Ambati BK, Patterson E, Jani P, et al. Soluble vascular endothelial growth factor receptor-1 contributes to the corneal antiangiogenic barrier. Br J Ophthalmol. 2007;91:505-508.
8. Febbraio M, Hajjar DP, Silverstein RL. CD36: a class B scavenger involved in angiogenesis, inflammation, atherosclerosis, and lipid metabolism. J Clin Invest. 2001;108:785-791.
9. Febbraio M, Abumrad NA, Hajjar DP, et al. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J Biol Chem. 1999;274:19055-19062.
10. Cursiefen C, Masli S, Ng TF, et al. Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis. Invest Ophthalmol Vis Sci. 2004;45:1117-24.
11. Niederer RL, Perumal D, Sherwin T, et al. Age-related differences in the normal human cornea: a laser scanning invivo confocal microscopy study. Br J Ophthalmol. 2007;91:1165-9.
12. Greenberg M, Sun M, Zhang R, et al. Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells. J Exp Med. 2006;203:2613-2625.
13. Cursiefen C, Chen L, Borges LP, et al. VEGF-A stimulates lymphangio-genesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. J Clin Invest. 2004;113:1040-1050.
14. Amano S, Rohan R, Kuroki M, et al. Requirement for vascular endothelial growth factor in wound- and inflammation-related corneal neovascula-rization. Invest Ophthalmol Vis Sci. 1998;39:18-22.
15. Philipp W, Speicher L, Humpel C. Expression of vascular endothelial growth factor and its receptors in inflamed and vascularized human corneas. Invest Ophthalmol Vis Sci. 2000;41:2514-2522.
16. Pedram A, Razandi M, Levin ER. Extracellular signal-regulated protein kinase/Jun kinase cross-talk underlies vascular endothelial cell growth factor-induced endothelial cell proliferation. J Biol Chem. 1998;273: 26722-26728.
17. Jimenez B, Volpert O, Crawford S, et al. Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat Med. 2000;6:41-48.
18. Primo L, Ferrandi C, Roca C, et al. Identification of CD36 molecular features required for its in vitro angiostatic activity. FASEB J. 2005;12: 1713-1715.