High resolution positron emission tomography demonstrates basal ganglia dysfunction in early Parkinson's disease

Journal of the Neurological Sciences

Volumn 276, Issue 1-2, 2009, Pages 27-30

  Eggers, C ^a   Hilker, R ^b   Burghaus, L ^a   Schumacher, B ^a   Heiss, W D ^c  

^a UNIVERSITY OF COLOGNE   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

Author keywords

Basal ganglia; Parkinson's disease; Positron emission tomography

Indexed keywords

AMANTADINE; BIOLOGICAL MARKER; CABERGOLINE; FLUORODEOXYGLUCOSE F 18; LEVODOPA; ROPINIROLE; SELEGILINE;

ADULT; AGED; AMYGDALOID NUCLEUS; ARTICLE; BASAL GANGLION; BRAIN DYSFUNCTION; BRAIN METABOLISM; BRAIN NERVE CELL; BRAIN NUCLEUS; CAUDATE NUCLEUS; CELL ACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG UPTAKE; FEMALE; GLOBUS PALLIDUS; GLUCOSE METABOLISM; HUMAN; MALE; METABOLIC RATE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEUS ACCUMBENS; PARKINSON DISEASE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUTAMEN; RED NUCLEUS; SUBSTANTIA NIGRA; SUBTHALAMIC NUCLEUS; THREE DIMENSIONAL IMAGING;

ADULT; AGED; AGED, 80 AND OVER; BASAL GANGLIA; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PARKINSON DISEASE; POSITRON-EMISSION TOMOGRAPHY; STATISTICS, NONPARAMETRIC;

EID: 58149154796     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2008.08.029     Document Type: Article

References (27)

1. Wichmann T., and DeLong M.R. Pathophysiology of Parkinson's disease: the MPTP primate model of the human disorder. Ann N Y Acad Sci 991 (2003) 199-213
2. Wichmann T., and DeLong M.R. Functional and pathophysiological models of the basal ganglia. Curr Opin Neurobiol 6 (1996) 751-758
3. Wienhard K., Schmand M., Casey M.E., Baker K., Bao J., Eriksson L., et al. The ECAT HRRT: performance and first clinical application of the new high resolution research tomograph. IEEE Trans Nucl Sci 49 (2002) 104-110
4. Heiss W.D., Habedank B., Klein J.C., Herholz K., Wienhard K., Lenox M., et al. Metabolic rates in small brain nuclei determined by high-resolution PET. J Nucl Med 45 (2004) 1811-1815
5. Hoehn M.M., and Yahr M.D. Parkinsonism: onset, progression and mortality. Neurology 17 (1967) 427-442
6. Fahn S., and E. R. a. t. M. o. t. U. D. C. Unified Parkinsons's Disease Rating Scale. In: Fahn S., M.C., and Goldstein M. (Eds). Recent Developments in Parkinsons's disease (1987), New York, NY 153-163
7. Hughes A.J., Daniel S.E., Kilford L., and Lees A.J. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55 (1992) 181-184
8. Bailey D.L. 3D acquisition and reconstruction in positron emission tomography. Ann Nucl Med 6 (1992) 123-130
9. 18F]2-fluoro-2-deoxy-d-glucose: a critical appraisal of optimization procedures. J Cereb Blood Flow Metab 5 (1985) 115-125
10. 11C]deoxyglucose. J Cereb Blood Flow Metab 5 (1985) 179-192
11. Herholz K., and Heiss W.D. Positron emission tomography in clinical neurology. Mol Imaging Biol 6 (2004) 239-269
12. Wienhard K. Measurement of glucose consumption using [(18)F]fluorodeoxyglucose. Methods 27 (2002) 218-225
13. Cizek J., Herholz K., Vollmar S., Schrader R., Klein J., and Heiss W.D. Fast and robust registration of PET and MR images of human brain. Neuroimage 22 (2004) 434-442
14. Stockhausen H-Mv P.U., and Herholz K. A method for surface-based quantification of functional data from the human cortex. In: Carson R.E., D-W M., and Herscovitch P. (Eds). Quantitative Functional Brain Imaging with Positron Emission Tomography (1998), Academic-Press, San Diego, CA 139-142
15. Duvernoy H. The Human Brain (1991), Springer-Verlag, New York
16. Truvit C.L., and L. T. High Resolution Atlas of Cranial Neuroanatomy (1994), Williams & Wilkins, Baltimore
17. Schaltenbrand G., and W. W. Atlas for Stereotaxy of the Human Brain (1977), Georg Thieme Publishers, Stuttgart, Germany
18. Eidelberg D., Moeller J.R., Dhawan V., Spetsieris P., Takikawa S., Ishikawa T., et al. The metabolic topography of parkinsonism. J Cereb Blood Flow Metab 14 (1994) 783-801
19. Alexander G.E., DeLong M.R., and Strick P.L. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 9 (1986) 357-381
20. Gjedde A., Marrett S., and Vafaee M. Oxidative and nonoxidative metabolism of excited neurons and astrocytes. J Cereb Blood Flow Metab 22 (2002) 1-14
21. Fukuda M., Edwards C., and Eidelberg D. Functional brain networks in Parkinson's disease. Parkinsonism Relat Disord 8 (2001) 91-94
22. Sokoloff L. Energetics of functional activation in neural tissues. Neurochem Res 24 (1999) 321-329
23. 18F-fluorodeoxyglucose and positron emission tomography. Neurology 45 (1995) 1995-2004
24. Wichmann T., and DeLong M.R. Pathophysiology of parkinsonian motor abnormalities. Adv Neurol 60 (1993) 53-61
25. Ghaemi M., Hilker R., Rudolf J., Sobesky J., and Heiss W.D. Differentiating multiple system atrophy from Parkinson's disease: contribution of striatal and midbrain MRI volumetry and multi-tracer PET imaging. J Neurol Neurosurg Psychiatry 73 (2002) 517-523
26. Moeller J.R., Ishikawa T., Dhawan V., Spetsieris P., Mandel F., Alexander G.E., et al. The metabolic topography of normal aging. J Cereb Blood Flow Metab 16 (1996) 385-398
27. Loessner A., Alavi A., Lewandrowski K.U., Mozley D., Souder E., and Gur R.E. Regional cerebral function determined by FDG-PET in healthy volunteers: normal patterns and changes with age. J Nucl Med 36 (1995) 1141-1149