Quantification of citalopram or escitalopram and their demethylated metabolites in neonatal hair samples by liquid chromatography-tandem mass spectrometry

Therapeutic Drug Monitoring

Volumn 30, Issue 4, 2008, Pages 467-473

  Frison, Giampietro ^a   Favretto, Donata ^a   Vogliardi, Susanna ^a   Terranova, Claudio ^a   Ferrara, Santo Davide ^a  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

Author keywords

Citalopram; Escitalopram; Hair analysis; In utero exposure; Iontrap; LC MS MS

Indexed keywords

CITALOPRAM; CLOMIPRAMINE; DEMETHYLCITALOPRAM; DEMETHYLESCITALOPRAM; DICHLOROMETHANE; DRUG METABOLITE; ESCITALOPRAM; ETHER; UNCLASSIFIED DRUG; SEROTONIN UPTAKE INHIBITOR;

ADULT; ARTICLE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; HAIR; HUMAN; HUMAN TISSUE; INFANT; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; CALIBRATION; CHEMISTRY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NEWBORN; PREGNANCY; REPRODUCIBILITY; STANDARD;

ADULT; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITALOPRAM; FEMALE; HAIR; HUMANS; INFANT, NEWBORN; MALE; PREGNANCY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SEROTONIN UPTAKE INHIBITORS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 58149121777     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/FTD.0b013e31817c6bc4     Document Type: Article

References (32)

1. Burke WJ. Escitalopram. Exp Opin Investig Drugs. 2002;11:1477-1486.
2. Oyehaug E, Ostensen ET, Salvesen B. High-performance liquid chromatographic determination of citalopram and four of its metabolites in plasma and urine samples from psychiatric patients. J Chromatogr. 1984;308:199-208.
3. Rampono J, Hackett LP, Kristensen JH, et al. Transfer of escitalopram and its metabolite demethylescitalopram into breastmilk. Br J Clin Pharmacol. 2006;62:316-322.
4. Baumann P. Pharmacology and pharmacokinetics of citalopram and other SSRIs. Int Clin Psychopharmacol. 1996;11:5-11.
5. Bezchlibnyk-Butler K, Aleksic I, Kennedy SH. Citalopram-a review of pharmacological and clinical effects. J Psychiatry Neurosci. 2000;25: 241-254.
6. Levinson-Castiel R, Merlob P, Linder N, et al. Neonatal abstinence syndrome after in utero exposure to selective serotonin reuptake inhibitors in term infants. Arch Pediatr Adolesc Med. 2006;160:173-176.
7. Bellantuono C, Migliarese G, Gentile S. Serotonin reuptake inhibitors in pregnancy and the risk of major malformations: a systematic review. Hum Psychopharmacol. 2007;22:121-128.
8. Potts AL, Young KL, Carter BS, et al. Necrotizing enterocolitis associated with in utero and breast milk exposure to the selective serotonin reuptake inhibitor, escitalopram. J Perinatol. 2007;27:120-122.
9. Olesen OV, Linnet K. Simplified high-performance liquid chromatographic method for the determination of citalopram and desmethylcitalopram in serum without interference from commonly used psychotropic drugs and their metabolites. J Chromatogr B Biomed Appl. 1996;675: 83-88.
10. Tournel G, Houdret N, Hedouin V, et al. High-performance liquid chromatographic method to screen and quantitate seven selective serotonin reuptake inhibitors in human serum. J Chromatogr B Biomed Sci Appl. 2001;761:147-158.
11. Frahnert C, Rao ML, Grasmader K. Analysis of eighteen antidepressants, four atypical antipsychotics and active metabolites in serum by liquid chromatography: a simple tool for therapeutic drug monitoring. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;794:35-47.
12. Akerman KK, Jolkkonen J, Huttunen H, et al. I. High-performance liquid chromatography method for analyzing citalopram and desmethylcitalopram from human serum. Ther Drug Monit. 1998;20:25-29.
13. Matsui E, Hoshino M, Matsui A, et al. Simultaneous determination of citalopram and its metabolites by high-performance liquid chromatography with column switching and fluorescence detection by direct plasma injection. J Chromatogr B Biomed Appl. 1995;668:299-307.
14. Kristoffersen L, Bugge A, Lundanes E, et al. Simultaneous determination of citalopram, fluoxetine, paroxetine and their metabolites in plasma and whole blood by high-performance liquid chromatography with ultraviolet and fluorescence detection. J Chromatogr B Biomed Sci Appl. 1999;734: 229-246.
15. Macek J, Ptacek P, Klima J. Rapid determination of citalopram in human plasma by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 2001;755:279-285.
16. Waschgler R, Hubmann MR, Conca A, et al. Simultaneous quantification of citalopram, clozapine, fluoxetine, norfluoxetine, maprotiline, desmethylmaprotiline and trazodone in human serum by HPLC analysis. Int J Clin Pharmacol Ther. 2002;40:554-559.
17. Eap CB, Bouchoux G, Amey M, et al. Simultaneous determination of human plasma levels of citalopram, paroxetine, sertraline, and their metabolites by gas chromatography- mass spectrometry. J Chromatogr Sci. 1998;36:365-371.
18. Pistos C, Panderi I, Atta-Politou J. Liquid chromatography-positive ion electrospray mass spectrometry method for the quantification of citalopram in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2004;810:235-244.
19. Juan H, Zhiling Z, Huande L. Simultaneous determination of fluoxetine, citalopram, paroxetine, venlafaxine in plasma by high performance liquid chromatography electrospray ionization mass spectrometry (HPLC-MS/ ESI). J Chromatogr B Analyt Technol Biomed Life Sci. 2005;820:33-39.
20. Kirchherr H, Kuhn-Velten WN. Quantitative determination of forty- eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach. J Chromatogr B Analyt Technol Biomed Life Sci. 2006;843:100-113.
21. Sauvage FL, Gaulier JM, Lachatre G, et al. A fully automated turbulent-flow liquid chromatography-tandem mass spectrometry technique for monitoring antidepressants in human serum. Ther Drug Monit. 2006;28: 123-130.
22. Singh SS, Shah H, Gupta S, et al. Liquid chromatography-electrospray ionisation mass spectrometry method for the determination of escitalopram in human plasma and its application in bioequivalence study. J Chromatogr B Analyt Technol Biomed Life Sci. 2004;811:209-215.
23. Salgado-Petinal C, Lamas JP, Garcia-Jares C, et al. Rapid screening of selective serotonin re-uptake inhibitors in urine samples using solid-phase microextraction gas chromatography-mass spectrometry. Anal Bioanal Chem. 2005;382:1351-1359.
24. Berzas Nevado JJ, Villasenor Llerena MJ, Guiberteau Cabanillas C, et al. Screening of citalopram, fluoxetine and their metabolites in human urine samples by gas chromatography-mass spectrometry. A global robustness/ruggedness study. J Chromatogr A. 2006;1123: 130-133.
25. Muller C, Vogt S, Goerke R, et al. Identification of selected psychopharmaceuticals and their metabolites in hair by LC/ESI-CID/ MS and LC/MS/MS. Forensic Sci Int. 2000;113:415-421.
26. Pragst F, Balikova MA. State of the art in hair analysis for detection of drug and alcohol abuse. Clin Chim Acta. 2006;370:17-49.
27. Bar-Oz B, Klein J, Karaskov T, et al. Comparison of meconium and neonatal hair analysis for detection of gestational exposure to drugs of abuse. Arch Dis Child Fetal Neonatal Ed. 2003;88:F98-100.
28. Kintz P, Tracqui A, Mangin P. Tobacco, drug and narcotic abuse during pregnancy. Evaluation of in utero exposure by analysis of hair of the neonate. Presse Med. 1992;21:2139-2141.
29. Favretto D, Frison G, Vogliardi S, et al. Highly-specific quantification of ergotamine in urine, blood and hair samples by LC-MS/MS. Ther Drug Monit. 2007;29:325-332.
30. Frison G, Favretto D, Tedeschi L, et al. Detection of thiopental and pentobarbital in head and pubic hair in a case of drug-facilitated sexual assault. Forensic Sci Int. 2003;133:171-174.
31. Smyth WF, Leslie JC, McClean S, et al. The characterization of selected antidepressant drugs using electrospray ionization with ion trap mass spectrometry and with quadrupole time-of-flight mass spectrometry and their determination by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2006;20:1637-1642.
32. Nikisch G, Mathe AA, Czernik A, et al. Stereoselective metabolism of citalopram in plasma and cerebrospinal fluid of depressive patients: relationship with 5-HIAA in CSF and clinical response. J Clin Psychopharmacol. 2004;24:283-290.