Transfer of escitalopram and its metabolite demethylescitalopram into breastmilk

British Journal of Clinical Pharmacology

Volumn 62, Issue 3, 2006, Pages 316-322

  Rampono, Jonathan ^a   Hackett, L Peter ^b   Kristensen, Judith H ^a   Kohan, Rolland ^a   Page Sharp, Madhu ^a,c   Ilett, Kenneth F ^a,c  

^a Women's and Children's Health Service   (Australia)

^b PATHWEST LABORATORY MEDICINE   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Breastmilk; Demethylescitalopram; Escitalopram; Infant dose; Infant wellbeing

Indexed keywords

DRUG METABOLITE; ESCITALOPRAM; NORESCITALOPRAM; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; BREAST FEEDING; BREAST MILK; CLINICAL ARTICLE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG SAFETY; DRUG TRANSPORT; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LACTATION; PRIORITY JOURNAL; PUERPERAL DEPRESSION; RISK BENEFIT ANALYSIS; STANDARD; STEADY STATE;

ADULT; ANTIDEPRESSIVE AGENTS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BREAST FEEDING; CITALOPRAM; FEMALE; HUMANS; INFANT; MALE; MILK, HUMAN;

EID: 33746454398     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2006.02659.x     Document Type: Article

References (26)

1. O'Hara MW, Zekoski EM, Philipps LH, Wright EJ. Controlled prospective study of postpartum mood disorders: comparison of childbearing and nonchildbearing women. J Abnorm Psychol 1990; 99: 3-15.
2. Sinclair D, Murray L. Effects of postnatal depression on children's adjustment to school. Teacher's reports. Br J Psychiatry 1998; 172: 58-63.
3. Murray L, Fiori-Cowley A, Hooper R, Cooper P. The impact of postnatal depression and associated adversity on early mother-infant interactions and later infant outcome. Child Dev 1996; 67: 2512-26.
4. Zekoski EM, O'Hara MW, Wills KE. The effects of maternal mood on mother-infant interaction. J Abnorm Child Psychol 1987; 15: 361-78.
5. Lee CM, Gotlib IH. Adjustment of children of depressed mothers: a 10-month follow-up. J Abnorm Psychol 1991; 100: 473-7.
6. Spigset O, Carieborg L, Ohman R, Norstrom A. Excretion of citalopram in breast milk. Br J Clin Pharmacol 1997; 44: 295-8.
7. Jensen PN, Olesen OV, Bertelsen A, Linnet K. Citalopram and desmethylcitalopram concentrations in breast milk and in serum of mother and infant. Therap Drug Monit 1997; 19: 236-9.
8. Ohman R, Norstedt B, Vitols WS. Citalopram and metabolite levels in plasma and breast milk in two nursing women. Br J Clin Pharmacol 1997; A179.
9. Rampono J, Kristensen JH, Hackett LP, Paech M, Kohan R, Ilett KF. Citalopram and demethylcitalopram in human milk; distribution, excretion and effects in breast fed infants. Br J Clin Pharmacol 2000; 50: 263-8.
10. Schmidt K, Olesen OV, Jensen PN. Citalopram and breast-feeding: serum concentration and side effects in the infant. Biol Psychiatry 2000; 47: 164-5.
11. Nordeng H, Bergsholm YK, Bohler E, Spigset O. Excretion of selective serotonin reuptake inhibitors in breast milk. Tidsskr Nor Laegeforen 2001; 121: 199-203.
12. Heikkinen T, Ekblad U, Kero P, Ekblad S, Laine K. Citalopram in pregnancy and lactation. Clin Pharmacol Ther 2002; 72: 184-91.
13. Baumann P, Zullino DF, Eap CB. Enantiomers' potential in psychopharmacology - a critical analysis with special emphasis on the antidepressant escitalopram. Eur Neuropsychopharmacol 2002; 12: 433-44.
14. Hyttel J, Bogeso KP, Perregaard J, Sanchez C. The pharmacological effect of citalopram residues in the (S)-(+)-enantiomer. J Neural Transm Gen Sect 1992; 88: 157-60.
15. Sanchez C, Bergqvist PB, Brennum LT, Gupta S, Hogg S, Larsen A, Wilborg O. Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities. Psychopharmacology (Berl) 2003; 167: 353-62.
16. Mork A, Kreilgaard M, Sanchez C. The R-enantiomer of citalopram counteracts escitalopram-induced increase in extracellular 5-HT in the frontal cortex of freely moving rats. Neuropharmacology 2003; 45: 167-73.
17. Sanchez C, Bogeso KP, Ebert B, Reines EH, Braestrup C. Escitalopram versus citalopram: the surprising role of the Renantiomer. Psychopharmacology (Berl) 2004; 174: 163-76.
18. Hale TW, Ilett KF. Drug Therapy and Breastfeeding. From Theory to Clinical Practice, 1st edn. London: The Parthenon Publishing Group 2002: 1-94.
19. Begg EJ, Malpas TJ, Hackett LP, Ilett KF. Distribution of R- and S-methadone into human milk at steady state during ingestion of medium to high doses. Br J Clin Pharmacol 2001; 52: 681-5.
20. Frankenburg WK, Dodds JB. The Denver development screening test. J Pediatr 1967; 71: 181-91.
21. Rossiter EJ. The use of developmental screening and assessment instruments by paediatricians in Australia. J Paediatr Child Health 1993; 29: 357-9.
22. Begg EJ, Duffull SB, Hackett LP, Ilett KF. Studying drugs in human milk: time to unify the approach. J Hum Lact 2002; 18: 319-28.
23. Bennett PN. Use of the monographs on drugs. In: Drugs and Human Lactation, 2nd edn, ed Bennett PN. Amsterdam: Elsevier 1996: 67-74.
24. Anonymous. Lexapro (escitalopram) Product Information. In: EMIMS Ver 5.00.0106. St Leonards, Australia: MultiMedia Australia Pty Ltd 2005.
25. Sidhu J, Priskorn M, Poulsen M, Segonzac A, Grollier G, Larsen F. Steady-state pharmacokinetics of the enantiomers of citalopram and its metabolites in humans. Chirality 1997; 9: 686-92.
26. Anonymous. Cipramil (rac-citalopram) Product Information. In: EMIMS Ver 5.00.0106. St Leonards, Australia: MultiMedia Australia Pty Ltd 2005.