Connexin 43 expression of foreign body giant cells after implantation of nanoparticulate hydroxyapatite

Biomaterials

Volumn 28, Issue 33, 2007, Pages 4912-4921

  Herde, Katja ^a   Hartmann, Sonja ^a   Brehm, Ralph ^a   Kilian, Olaf ^a   Heiss, Christian ^a   Hild, Anne ^a   Alt, Volker ^a   Bergmann, Martin ^a   Schnettler, Reinhard ^a   Wenisch, Sabine ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Bone; Connexin 43; Foreign body giant cells; Fusion; Hydroxyapatite

Indexed keywords

BIOMATERIALS; BONE; CELLS; HYDROXYAPATITE; NANOPARTICLES; RNA;

CONNEXIN 43; FOREIGN BODY GIANT CELLS (FBGC); GAP JUNCTIONS; IMMUNOHISTOCHEMISTRY; MONONUCLEAR PRECURSORS;

GENE EXPRESSION;

BIOMATERIAL; CONNEXIN 43; HYDROXYAPATITE; MESSENGER RNA; NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL LINEAGE; CONTROLLED STUDY; CYTOPLASM; ENZYME HISTOCHEMISTRY; GAP JUNCTION; GIANT CELL; IMMUNOHISTOCHEMISTRY; IMPLANTATION; IN SITU HYBRIDIZATION; MACROPHAGE; MINIPIG; MONOCYTE; MULTINUCLEAR CELL; NONHUMAN; OSTEOBLAST; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; UBIQUITINATION; ULTRASTRUCTURE; WESTERN BLOTTING;

ACID PHOSPHATASE; ANIMALS; BIOCOMPATIBLE MATERIALS; BONE AND BONES; CONNEXIN 43; DURAPATITE; GAP JUNCTIONS; GIANT CELLS, FOREIGN-BODY; IN SITU HYBRIDIZATION; ISOENZYMES; MACROPHAGES; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; OSTEOCLASTS; SWINE; SWINE, MINIATURE;

EID: 34548399453     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2007.07.027     Document Type: Article

References (42)

1. Vignery A. Macrophage fusion: the making of osteoclasts and giant cells. J Exp Med 202 (2005) 337-340
2. Vignery A. Osteoclasts and giant cells: macrophage-macrophage fusion mechanism. Int J Exp Pathol 81 (2000) 291-304
3. Most J., Spotl L., Mayr G., Gasser A., Sarti A., and Dierich M.P. Formation of multinucleated giant cells in vitro is dependent on the stage of monocyte to macrophage maturation. Blood 89 (1997) 662-671
4. Eugenin E.A., Branes M.C., Berman J.W., and Saez J.C. TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses. J Immunol 170 (2003) 1320-1328
5. Ilvesaro J., Vaananen K., and Tuukkanen J. Bone-resorbing osteoclasts contain gap-junctional connexin-43. J Bone Miner Res 15 (2000) 919-926
6. Collier T.O., Anderson J.M., Brodbeck W.G., Barber T., and Healy K.E. Inhibition of macrophage development and foreign body giant cell formation by hydrophilic interpenetrating polymer network. J Biomed Mater Res A 69 (2004) 644-650
7. Collier T.O., and Anderson J.M. Protein and surface effects on monocyte and macrophage adhesion, maturation, and survival. J Biomed Mater Res 60 (2002) 487-496
8. Matheson L.A., Santerre J.P., and Labow R.S. Changes in macrophage function and morphology due to biomedical polyurethane surfaces undergoing biodegradation. J Cell Physiol 199 (2004) 8-19
9. Brodbeck W.G., Shive M.S., Colton E., Nakayama Y., Matsuda T., and Anderson J.M. Influence of biomaterial surface chemistry on the apoptosis of adherent cells. J Biomed Mater Res 55 (2001) 661-668
10. Brodbeck W.G., Patel J., Voskerician G., Christenson E., Shive M.S., Nakayama Y., et al. Biomaterial adherent macrophage apoptosis is increased by hydrophilic and anionic substrates in vivo. Proc Natl Acad Sci USA 99 (2002) 10287-10292
11. Anderson J.M. Multinucleated giant cells. Curr Opin Hematol 7 (2000) 40-47
12. Matheson L.A., Santerre J.P., and Labow R.S. Changes in macrophage function and morphology due to biomedical polyurethane surfaces undergoing biodegradation. J Cell Physiol 199 (2004) 8-19
13. Brodbeck W.G., Shive M.S., Colton E., Ziats N.P., and Anderson J.M. Interleukin-4 inhibits tumor necrosis factor-alpha-induced and spontaneous apoptosis of biomaterial-adherent macrophages. J Lab Clin Med 139 (2002) 90-100
14. Most J., Spotl L., Mayr G., Gasser A., Sarti A., and Dierich M.P. Formation of multinucleated giant cells in vitro is dependent on the stage of monocyte to macrophage maturation. Blood 89 (1997) 662-671
15. Athanasou N.A., and Path F.R.C. Current Concepts Review-Cellular biology of bone-resorbing cells. J Bone Joint Surg [Am] 78-A (1996) 1096-1112
16. Kilian O., Alt V., Heiss C., Jonuleit T., Dingeldein E., Flesch I., et al. New blood vessel formation and expression of VEGF receptors after implantation of platelet growth factor-enriched biodegradable nanocrystalline hydroxyapatite. Growth Factors 23 (2005) 125-133
17. Tadic D., and Epple M. A thorough physicochemical characterisation of 14 calcium phosphate based bone substitution materials in comparison to natural bone. Biomaterials 25 (2004) 987-994
18. Tadic D., Peters F., and Epple M. Continuous synthesis of amorphous carbonated apatites. Biomaterials 23 (2002) 2553-2559
19. Brehm R., Ruttinger C., Fischer P., Gashaw I., Winterhager E., Kliesch S., et al. Transition from preinvasive carcinoma in situ to seminoma is accompanied by a reduction of connexin 43 expression in sertoli cells and germ cells. Neoplasia 8 (2006) 499-509
20. Wenisch S., Trinkaus K., Hild A., Hose D., Herde K., Heiss C., et al. Human reaming debris: a source of multipotent stem cells. Bone 36 (2005) 74-83
21. Ransjo M., Sahli J., and Lie A. Expression of connexin 43 mRNA in microisolated murine osteoclasts and regulation of bone resorption in vitro by gap junction inhibitors. Biochem Biophys Res Commun 303 (2002) 1179-1185
22. Leithe E., Brech A., and Rivedal E. Endocytic processing of connexin43 gap junctions: a morphological study. Biochem J 393 (2006) 59-67
23. Schnettler R., Alt V., Dingeldein E., Pfefferle H.-J., Kilian O., Meyer C., et al. Bone ingrowth in bFGF-coated hydroxyapatite ceramic impülants. Biomaterials 24 (2003) 4603-4608
24. McNally A.K., and Anderson J.M. Beta1 and beta2 integrins mediate adhesion during macrophage fusion and multinucleated foreign body giant cell formation. Am J Pathol 160 (2002) 621-630
25. Sterling H., Saginario C., and Vignery A. CD44 occupancy prevents macrophage multinucleation. J Cell Biol 143 (1998) 837-847
26. Suzuki K., Zhu B., Rittling S.R., Denhardt D.T., Goldberg H.A., McCulloch C.A., et al. Colocalization of intracellular osteopontin with CD44 is associated with migration, cell fusion, and resorption in osteoclasts. J Bone Miner Res 17 (2002) 1486-1497
27. DeFife K.M., Jenney C.R., Colton E., and Anderson J.M. Disruption of filamentous actin inhibits human macrophage fusion. FASEB J 13 (1999) 823-832
28. Jordan K., Chodock R., Hand A.R., and Laird D.W. The origin of annular junctions: a mechanism of gap junction internalization. J Cell Sci 114 (2001) 763-773
29. Beardslee M.A., Laing J.G., Beyer E.C., and Saffitz J.E. Rapid turnover of connexin43 in the adult rat heart. Circ Res 83 (1998) 629-635
30. Lampe P.D. Analyzing phorbol ester effects on gap junctional communication: a dramatic inhibition of assembly. J Cell Biol 127 (1994) 1895-1905
31. Musil L.S., Beyer E.C., and Goodenough D.A. Expression of the gap junction protein connexin43 in embryonic chick lens: molecular cloning, ultrastructural localization, and post-translational phosphorylation. J Membr Biol 116 (1990) 163-175
32. Saez J.C., Berthoud V.M., Branes M.C., Martinez A.D., and Beyer E.C. Plasma membrane channels formed by connexins: their regulation and functions. Physiol Rev 83 (2003) 1359-1400
33. Solan J.L., and Lampe P.D. Connexin phosphorylation as a regulatory event linked to gap junction channel assembly. Biochim Biophys Acta 1711 (2005) 154-163
34. Laird D.W., Castillo M., and Kasprzak L. Gap junction turnover, intracellular trafficking, and phosphorylation of connexin43 in brefeldin A-treated rat mammary tumor cells. J Cell Biol 131 (1995) 1193-1203
35. Puranam K.L., Laird D.W., and Revel J.P. Trapping an intermediate form of connexin43 in the Golgi. Exp Cell Res 206 (1993) 85-92
36. Saez J.C., Berthoud V.M., Branes M.C., Martinez A.D., and Beyer E.C. Plasma membrane channels formed by connexins: their regulation and functions. Physiol Rev 83 (2003) 1359-1400
37. Lampe P.D., and Lau A.F. Regulation of gap junctions by phosphorylation of connexins. Arch Biochem Biophys 384 (2000) 205-215
38. Laird D.W. Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation. Biochim Biophys Acta 1711 (2005) 172-182
39. Musil L.S., Cunningham B.A., Edelman G.M., and Goodenough D.A. Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines. J Cell Biol 111 (1990) 2077-2088
40. Falk M.M. Biosynthesis and structural composition of gap junction intercellular membrane channels. Eur J Cell Biol 79 (2000) 564-574
41. Fujimoto K., Nagafuchi A., Tsukita S., Kuraoka A., Ohokuma A., and Shibata Y. Dynamics of connexins, E-cadherin and alpha-catenin on cell membranes during gap junction formation. J Cell Sci 110 Pt 3 (1997) 311-322
42. Johnson R., Hammer M., Sheridan J., and Revel J.P. Gap junction formation between reaggregated Novikoff hepatoma cells. Proc Natl Acad Sci USA 71 (1994) 4536-4540