Synthesis and in vitro antibacterial activity of (2S)-N-(substitutedphenyl) -1-[(2R)-2-[(formylhydroxyamino)methyl]-1-oxohexyl]-2-pyrrolidinecarboxamides as potential peptide deformylase inhibitors

Chemical Biology and Drug Design

Volumn 73, Issue 1, 2009, Pages 142-146

  Wang, Zhenyu ^a   Zhou, Weicheng ^a  

^a SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY   (China)

Author keywords

Antibacterial agent; Gram positive bacteria; Inhibitor; Peptide deformylase

Indexed keywords

1 [2 [(FORMYLHYDROXYAMINO)METHYL] 1 OXOHEXYL] 2 PYRROLIDINECARBOXAMIDE; AMIDE; N (5 FLUORO 1 OXIDO 2 PYRIDINYL) 1 [2 (N FORMYL N HYDROXYAMINOMETHYL)HEXANOYL]PROLINAMIDE; PEPTIDE DEFORMYLASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; NONHUMAN; PRIORITY JOURNAL;

AMIDES; AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PEPTIDES;

POSIBACTERIA;

EID: 58149100674     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2008.00753.x     Document Type: Article

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